1. Microporotriol, a new cadinane-type sesquiterpenoid from the cultures of the wood-decay fungus Microporus affinis HFG829
- Author
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He-Ping Chen, Ji-Kai Liu, and Zhen-Zhu Zhao
- Subjects
biology ,010405 organic chemistry ,Stereochemistry ,Chemistry ,Organic Chemistry ,Plant Science ,Fungus ,Secondary metabolite ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,Wood-decay fungus ,010404 medicinal & biomolecular chemistry ,medicine ,Fermentation broth ,Cytotoxicity ,Two-dimensional nuclear magnetic resonance spectroscopy ,Microporus affinis ,medicine.drug ,Polyporaceae - Abstract
A new cadinane-type sesquiterpenoid, microporotriol (1), together with four known compound, 5-methylresorcinol (2), (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (3), (22E,24R)-ergosta-5,7,22-trien-3β-ol (4), (22E,24R)-5α,8α-epidioxy-ergosta-6,22-dien-3β-ol (5), were isolated from the fermentation broth of the wood decaying fungus Microporus affinis HFG829. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, along with HRMS spectroscopic analysis. The relative configuration of 1 was confirmed by NMR calculation. Compound 1 was evaluated for the cytotoxicity against five human cancer cell lines.
- Published
- 2019
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