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Three new sugar alcohol conjugated acyclic sesquiterpenes, cosmosporasides F–H (1–3), were isolated from the fermented cultures of Fusarium oxysporum SC0002. Their structures were elucidated by extensive analysis of spectroscopic data, including 1H−13C long-range coupling constants (JC,H). Their antibacterial, cytotoxic and anti-inflammatory activities were evaluated. [ABSTRACT FROM AUTHOR]

Two new 2H-pyranones (1 and 2), two new isocoumarins (4 and 5), and two known compounds (3 and 6) were obtained from solid cultures of the endophytic fungus Pestalotiopsis microspora SC3082. Their structures and revision of the absolute stereochemistry of 6 were established by spectroscopic analyses and computational calculations. Compounds 2, 4 and 6 displayed moderate antifungal activities against Candida albicans ATCC 10321 with MIC values of 25.0, 25.0, and 12.5 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A novel icariin type flavonoid glycoside with a malonaldehydic acid intramolecular ester and two known flavonoid glycosides were isolated from Epimedium pseudowushanense. Their structures were elucidated on the basis of spectroscopic analysis and comparison of their data to the values reported in the literatures. The anti-inflammatory activities of these compounds icariin 3′′′-O-malonaldehydic acid intramolecular 1′′′′, 2′′′ ester (1), icariin (2) and epimedin C (3) were tested. The results indicated that compounds 1, 2 and 3 showed maximal inhibitory ratio of 27.91, 44.80 and 46.61%, respectively in in vitro anti-inflammatory activity on LPS-induced TNF-α secretion in RAW264.7 cells. Compounds icariin (2) and epimedin C (3) were found to inhibit the secretion of TNF-α to a comparable degree as quercetin. [ABSTRACT FROM AUTHOR]

Two new γ-pyrones, xylaropyrones B (1) and C (2), together with three known compounds, xylaropyrone (3), annularin A (4) and annularin C (5), were isolated from solid cultures of the endophytic fungus Xylaria sp. SC1440. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative configurations of 1 and 2 were assigned on the basis of J-based configurational analysis, and the absolute configurations were established by experimental and TDDFT calculated ECD spectra. The isolated compounds were evaluated for cytotoxic and tyrosinase inhibitory activity. [ABSTRACT FROM AUTHOR]

A new lovastatin analogue versicorin (1), together with three related compounds, decumbenones A (2) and B (3) and versiol (4), were isolated from mycelial solid cultures of Aspergillus versicolor SC0156. Their structures were elucidated on the basis of MS data and NMR spectroscopic analysis. The new compound versicorin (1) possesses a hexahydro-2H-naphtho[1,8-bc]furan moiety, which is a rare type of the lovastatin-analogous compounds. A hypothetical biosynthetic pathway for compounds 1–4 was proposed. [ABSTRACT FROM AUTHOR]

Two new 2 H -pyranones ( 1 and 2 ), two new isocoumarins ( 4 and 5 ), and two known compounds ( 3 and 6 ) were obtained from solid cultures of the endophytic fungus Pestalotiopsis microspora SC3082. Their structures and revision of the absolute stereochemistry of 6 were established by spectroscopic analyses and computational calculations. Compounds 2 , 4 and 6 displayed moderate antifungal activities against Candida albicans ATCC 10321 with MIC values of 25.0, 25.0, and 12.5 μg/mL, respectively.