1. Glyco-conjugation in 3-β-anhydroicaritine.
- Author
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Zhao, Zhao, Cui, Hanqi, Wang, Xianheng, Zhang, Jianyong, and Zhao, Changkuo
- Subjects
STRUCTURE-activity relationships ,CYTOTOXINS - Abstract
A convenient method has been developed for the glycol-conjugation in 3-position of β-anhydroicaritine in a reasonable yield. The structure of the 3-glycosylated β-anhydroicaritine derivatives was confirmed to be correct by
1 H NMR,13 C NMR and HRMS spectrum. These compounds are less soluble than icaritin, but more soluble than icariside II in CCl4 . The screening results showed that compounds 12h, 12i and 12j had higher cytotoxicity to HepG2 and MCF-7 at a concentration of 50 μM. [ABSTRACT FROM AUTHOR]- Published
- 2024
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