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The article reports on the resignation of Bambang Parmanto, the editor-in-chief of "The Open Information Science Journal" in Pittsburgh, Pennsylvania. It notes that the Parmanto claimed the its publisher Bentham Science Publishing received a fake article without his knowledge. Mahmood Alam, director of publications at Bentham Science Publishing emphasizes the conviction of submitting fake manuscripts because of its being unethical.

The article tackles one of the biggest problems with clinical trial reporting, the suppression of negative results. Christine Lane, an editor at the Annals of Internal Medicine in Philadelphia, Pennsylvania called the archiving of medical investigation results as phantom papers. The practice of having phantom papers would give an over-optimistic impression of the treatments studied, with consequences for peer reviewers, government regulators and maximizing patients.

The article examines the development of methods measuring the activity of one of sirtuin's mammalian forms, SIRT1, by biochemistry director Konrad Howitz in Pennsylvania. Study shows that sirtuin lengthen the lifespan of yeast which lead to the establishment of these methods. It expects that compounds activating sirtuins may have the caloric restriction benefits with no starvation. It points out that biologist David Sinclair co-founded Sirtris to explore these enzymes which are associated to lifespan and ageing.

The article reports that Gerald Schatten which was recently exposed for faking the results of cloning experiments was cleared of misconduct by University of Pittsburgh in Philadelphia, Pennsylvania. An investigation was conducted by the university after claims in a paper that he had co-authored the cloning research which turned out to be false.

The article focuses on the research of the direct link between a metabolic enzyme called ATP citrate lyase (ACL) with gene expression changes by Craig Thompson ad his colleagues at the University of Pennsylvania in Philadelphia, Pennsylvania. It notes the influence of ACL on the function and histories of DNA. Furthermore, the researchers discovered the modification of ACL through the attachment of phosphorus on the proteins.

The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR–ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leukaemia samples from 304 individuals with ALL, including 43 BCR–ABL1 B-progenitor ALLs and 23 CML cases. IKZF1 (encoding the transcription factor Ikaros) was deleted in 83.7% of BCR–ABL1 ALL, but not in chronic-phase CML. Deletion of IKZF1 was also identified as an acquired lesion at the time of transformation of CML to ALL (lymphoid blast crisis). The IKZF1 deletions resulted in haploinsufficiency, expression of a dominant-negative Ikaros isoform, or the complete loss of Ikaros expression. Sequencing of IKZF1 deletion breakpoints suggested that aberrant RAG-mediated recombination is responsible for the deletions. These findings suggest that genetic lesions resulting in the loss of Ikaros function are an important event in the development of BCR–ABL1 ALL. [ABSTRACT FROM AUTHOR]

An interview with researcher Shelley Berger from the Wistar Institute in Philadelphia, Pennsylvania is presented. When asked how did they started their project related Sir2, an enzyme known as deacetylase, she refers to her desire in understanding the involvement of chromatin in aging. She also states that the they were surprised upon knowing that Sir2 protein levels decreases as yeast get older.

The article provides information on the inadequacy of climate models to replicate climate at high latitudes. Lee Kump and David Pollard of Pennsylvania State University in University Park proposed that marine phytoplankton that emit dimethylsulphide became thermally stressed during the Cretaceous period. According to the article, the work of Kump and Pollard are ultimately unsatisfactory. It states that the effects of heat on biological aerosol emissions need to be better described in their climate model to yield solid conclusions.

The article features the study conducted by James Cowin of Pacific Northwest National Laboratory in Richland, Washington and Richard Bell of Pennsylvania State University in Altoona, Pennsylvania regarding the significance of ice in generating voltage. Research shows that ice can furnish voltage when heated or cooled. It can be done by depositing ions at -113°C onto a 1-micrometre-thick ice film, thereby charging the surface of the film and rotating its water molecules, which become locked in position when the film is later cooled. They also discovered that same process could cause an electrostatic attraction between ice grains exposed to cosmic rays in space, thus promoting their aggregation into proto-planetary lumps.