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The British Journal of Anaesthesia's unusual experiment is designed to broaden replicability efforts beyond just methods and results. The British Journal of Anaesthesia's unusual experiment is designed to broaden replicability efforts beyond just methods and results., Author(s): David Adam Author Affiliations: Reproducibility trial publishes two conclusions for one paper Anaesthesia has been linked to delirium and death in older patients. [see PDF for image] Credit: BSIP/UIG [...]

Studies involving hundreds, even thousands, of scientists are on the rise, but how do such large groups coordinate their work? [ABSTRACT FROM AUTHOR]

Screening method detects Zika and chikungunya viruses using materials that fit onto easily transported paper test cards. [ABSTRACT FROM AUTHOR]

Investigations suggest that, in some fields, at least one-quarter of clinical trials might be problematic or even entirely made up, warn some researchers. They urge stronger scrutiny. [ABSTRACT FROM AUTHOR]

The field is taking a leap forward thanks to innovative technologies, such as artificial intelligence. Researchers must improve consent procedures and public involvement. [ABSTRACT FROM AUTHOR]

Scientific papers made free to access during the pandemic are rumoured to be disappearing behind paywalls. They aren’t — yet. [ABSTRACT FROM AUTHOR]

How certain subgroups of a childhood brain tumour called a medulloblastoma arise has been unclear. Evidence now implicates a cell type found only in developing human brains as the originator of these tumours. Brain cells that give rise to certain types of cancer identified. [ABSTRACT FROM AUTHOR]

Since 2022, more than 1,000 cases of childhood hepatitis with no known cause have been reported. The discovery of adeno-associated virus 2 in the blood and livers of such children might provide an explanation. Adeno-associated virus 2 might be involved in paediatric hepatitis cases. [ABSTRACT FROM AUTHOR]

Assessing the genetic and cellular changes that underlie human lung cancer as it evolves could aid the development of treatments. The TRACERx project reports data from studies tracking the disease. The TRACERx project reports data from studies tracking human lung cancer. [ABSTRACT FROM AUTHOR]

Genomic analysis reveals a host of genetic variants that affect how quickly fertility ends, among them one that reduces reproductive span by six years. [ABSTRACT FROM AUTHOR]

Researchers say that the model behind the chatbot fabricated a convincing bogus database, but a forensic examination shows it doesn’t pass for authentic. [ABSTRACT FROM AUTHOR]

Advances in understanding the causes of the autoimmune disorder could aid in matching people with the right treatment. [ABSTRACT FROM AUTHOR]

Soft solids that swell with shifts in pressure, temperature and pH provide a way of detecting such changes in the fluid around the brain. The method could be used to determine other properties of fluids elsewhere in the body.Injectable hydrogels gauge changes in the brain. [ABSTRACT FROM AUTHOR]

Humans can be picky eaters. One such behaviour is an aversion to food associated with food allergy. The immunological basis for this response has been uncovered in mice, revealing the role of neuroimmune connections.The immunological basis for allergy-associated aversion to food. [ABSTRACT FROM AUTHOR]

Malignant stem cells in the gut secrete factors that promote the differentiation of neighbouring stem cells, thereby aiding the replacement of normal stem cells by those with cancer-promoting mutations. Insights into how mutant stem cells outcompete normal stem cells. [ABSTRACT FROM AUTHOR]

Animals that receive an inhibitor of an antiviral cell-death response called necroptosis are less likely to die of influenza even at a late stage of infection. This has implications for the development of therapies for respiratory diseases.Inhibiting necroptosis protects lungs against influenza-mediated damage. [ABSTRACT FROM AUTHOR]

The hundreds of receptors that give us our sense of smell have been found to have important roles in other parts of the body, and the prospect of targeting them with drugs is growing. [ABSTRACT FROM AUTHOR]

Although some countries have made marked strides in reporting trial results, others still face a long road ahead. [ABSTRACT FROM AUTHOR]

Pulses of light and sound seem to have beneficial effects. But some argue it is too soon to market experimental devices. [ABSTRACT FROM AUTHOR]

Non-invasive, non-pharmacological approaches such as virtual-reality therapy and yoga can help to relieve chronic pain. [ABSTRACT FROM AUTHOR]

What drives sex biases in the immune system? Examining how gender-affirming therapy affects the molecular profiles of immune cells of trans men reveals how hormones underpin immune responses.The molecular profile of immune cells of trans men. [ABSTRACT FROM AUTHOR]

The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells. [ABSTRACT FROM AUTHOR]

Researcher who established the role of cellular senescence in cancer and ageing. [ABSTRACT FROM AUTHOR]

In 2008, the first comprehensive sequence of a cancer genome was reported, ushering in a new era of molecular diagnostic, prognostic and therapeutic advances informed by an essential framework to understand cancer’s complexities.Advances made since the era of genome analysis of cancer cells commenced. [ABSTRACT FROM AUTHOR]

A raft of alterations to the pig genome — removing three antigen-encoding genes, adding seven human genes and eliminating a retrovirus — allows kidneys to be transplanted into monkeys, with implications for clinical trials.Genetic engineering for pig-to-primate kidney transplants. [ABSTRACT FROM AUTHOR]

Understanding the processes that lead to tumour formation in the pancreas might help in efforts to develop therapies. A new bioinformatics tool called Calligraphy analyses cell–cell signalling to provide fresh insights into how tumours arise.Insights into early events during the formation of pancreatic cancer. [ABSTRACT FROM AUTHOR]

Rising death rates are defying global trends but the continent’s researchers are keen to lead the fightback. [ABSTRACT FROM AUTHOR]

A new analysis traces the story of the draft genome’s impact on genomics since 2001, linking its effects on publications, drug approvals and understanding of disease. [ABSTRACT FROM AUTHOR]

Hundreds of medical algorithms have been approved on basis of limited clinical data. Scientists are debating who should test these tools and how best to do it. [ABSTRACT FROM AUTHOR]

Scientists are closing in on biomarkers that reflect the progression of Alzheimer’s disease and could improve treatments. [ABSTRACT FROM AUTHOR]

How spreading tumour cells gain the ability to grow in organs away from where they originated is not fully understood. The discovery that normal liver cells help invading tumour cells to thrive in this organ sheds light on this process.How healthy cells influence whether cancer spreads at a secondary site. [ABSTRACT FROM AUTHOR]

Controlled infection with SARS-CoV-2 of people who hadn’t previously been exposed to the virus reveals how molecular and cellular signatures of the immune response portend effective defence against COVID-19.Controlled human infection with SARS-CoV-2 to track defence responses. [ABSTRACT FROM AUTHOR]

The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan. [ABSTRACT FROM AUTHOR]

Svetlana Mojsov led early studies of GLP-1, the hormone behind Wegovy, Ozempic and other blockbusters. [ABSTRACT FROM AUTHOR]

Two brain–computer interfaces have been developed that bring unprecedented capabilities for translating brain signals into sentences — at speeds close to that of normal speech, and with vocabularies exceeding 1,000 words. Thoughts converted to sentences at speeds nearing that of normal speech. [ABSTRACT FROM AUTHOR]

Two studies now shed light on how chromosomes that undergo catastrophic shattering are transmitted to daughter cells during cell division, thereby enabling them to be reassembled for the benefit of cancer cells.Chromothripsis clues about how cells inherit fragmented chromosomes. [ABSTRACT FROM AUTHOR]

Therapies that treat while diagnosing — theranostics — can extend length of survival and improve the quality of life for some people with advance-stage cancer. [ABSTRACT FROM AUTHOR]

Our immune system falters over time, which could explain the negative effects of ageing. [ABSTRACT FROM AUTHOR]

With key long COVID trials yet to yield results, people with the condition are trying to change how clinical trials are done. [ABSTRACT FROM AUTHOR]

An approach that aims to quantify how long a drug can delay or halt the progression of disease is gathering steam. [ABSTRACT FROM AUTHOR]

Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field. [ABSTRACT FROM AUTHOR]

Mutations of the NOD2 gene are risk factors for Crohn's disease. Many aspects of how they contribute to the condition are unknown. The discovery of cell populations that are involved suggests new therapeutic options. Cell populations shed light on how NOD2 mutations contribute to disease. [ABSTRACT FROM AUTHOR]

Sophisticated experimental approaches reveal cellular and immune-system mechanisms that enable rare HIV-infected cells to persist for decades in people who are taking antiretroviral drugs.Mechanisms that explain how HIV-infected cells survive for decades. [ABSTRACT FROM AUTHOR]

Extensive scans reveal rhythmic changes in the brain throughout the menstrual cycle and while on the pill.Hours spent in a brain-imaging machine revealed rhythmic changes in brain volume and connectivity. [ABSTRACT FROM AUTHOR]

In brain tumours, immune cells called macrophages scavenge lipid debris from the myelin sheath of neurons. These lipid-laden macrophages cause immunosuppression, and their transfer of lipids to tumours fuels cancer growth. How macrophage cells drive immunosuppression and brain tumour growth. [ABSTRACT FROM AUTHOR]

Microorganisms that normally reside in the gut can help to block microbial infection. A group of bacteria that lives in the human gut has been identified that can consume a nutrient needed by pathogenic bacteria. Depletion of the molecule gluconate halts gut colonization by a pathogen. [ABSTRACT FROM AUTHOR]

The human brain is usually considered to be beyond the reach of most immune cells. However, analysis of people who have brain tumours has revealed tumour-targeting T cells of the immune system in skull bones near the cancer site.Tumour-targeting T cells found in skull bones near human brain cancer. [ABSTRACT FROM AUTHOR]

Boosting the heart’s natural countermeasures against poor function is one way to treat heart failure, but existing therapies need to be given frequently. An antibody with enduring effects could offer a solution.Enhancing hormone activity enduringly lowers blood pressure. [ABSTRACT FROM AUTHOR]

The immune-signalling protein TNF has an essential role in inflammatory responses. Two people who were found to have no functional TNF are surprisingly healthy and able to fend off most infections, but are susceptible to tuberculosis. Insights about the immune system of people who lack a defence protein. [ABSTRACT FROM AUTHOR]