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The field is taking a leap forward thanks to innovative technologies, such as artificial intelligence. Researchers must improve consent procedures and public involvement. [ABSTRACT FROM AUTHOR]

Genomic analysis reveals a host of genetic variants that affect how quickly fertility ends, among them one that reduces reproductive span by six years. [ABSTRACT FROM AUTHOR]

Advances in understanding the causes of the autoimmune disorder could aid in matching people with the right treatment. [ABSTRACT FROM AUTHOR]

Soft solids that swell with shifts in pressure, temperature and pH provide a way of detecting such changes in the fluid around the brain. The method could be used to determine other properties of fluids elsewhere in the body.Injectable hydrogels gauge changes in the brain. [ABSTRACT FROM AUTHOR]

Animals that receive an inhibitor of an antiviral cell-death response called necroptosis are less likely to die of influenza even at a late stage of infection. This has implications for the development of therapies for respiratory diseases.Inhibiting necroptosis protects lungs against influenza-mediated damage. [ABSTRACT FROM AUTHOR]

Although some countries have made marked strides in reporting trial results, others still face a long road ahead. [ABSTRACT FROM AUTHOR]

Pulses of light and sound seem to have beneficial effects. But some argue it is too soon to market experimental devices. [ABSTRACT FROM AUTHOR]

Non-invasive, non-pharmacological approaches such as virtual-reality therapy and yoga can help to relieve chronic pain. [ABSTRACT FROM AUTHOR]

What drives sex biases in the immune system? Examining how gender-affirming therapy affects the molecular profiles of immune cells of trans men reveals how hormones underpin immune responses.The molecular profile of immune cells of trans men. [ABSTRACT FROM AUTHOR]

The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells. [ABSTRACT FROM AUTHOR]

Researcher who established the role of cellular senescence in cancer and ageing. [ABSTRACT FROM AUTHOR]

Hundreds of medical algorithms have been approved on basis of limited clinical data. Scientists are debating who should test these tools and how best to do it. [ABSTRACT FROM AUTHOR]

Scientists are closing in on biomarkers that reflect the progression of Alzheimer’s disease and could improve treatments. [ABSTRACT FROM AUTHOR]

How spreading tumour cells gain the ability to grow in organs away from where they originated is not fully understood. The discovery that normal liver cells help invading tumour cells to thrive in this organ sheds light on this process.How healthy cells influence whether cancer spreads at a secondary site. [ABSTRACT FROM AUTHOR]

Controlled infection with SARS-CoV-2 of people who hadn’t previously been exposed to the virus reveals how molecular and cellular signatures of the immune response portend effective defence against COVID-19.Controlled human infection with SARS-CoV-2 to track defence responses. [ABSTRACT FROM AUTHOR]

The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan. [ABSTRACT FROM AUTHOR]

Therapies that treat while diagnosing — theranostics — can extend length of survival and improve the quality of life for some people with advance-stage cancer. [ABSTRACT FROM AUTHOR]

Our immune system falters over time, which could explain the negative effects of ageing. [ABSTRACT FROM AUTHOR]

With key long COVID trials yet to yield results, people with the condition are trying to change how clinical trials are done. [ABSTRACT FROM AUTHOR]

An approach that aims to quantify how long a drug can delay or halt the progression of disease is gathering steam. [ABSTRACT FROM AUTHOR]

Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field. [ABSTRACT FROM AUTHOR]

Extensive scans reveal rhythmic changes in the brain throughout the menstrual cycle and while on the pill.Hours spent in a brain-imaging machine revealed rhythmic changes in brain volume and connectivity. [ABSTRACT FROM AUTHOR]

In brain tumours, immune cells called macrophages scavenge lipid debris from the myelin sheath of neurons. These lipid-laden macrophages cause immunosuppression, and their transfer of lipids to tumours fuels cancer growth. How macrophage cells drive immunosuppression and brain tumour growth. [ABSTRACT FROM AUTHOR]

Microorganisms that normally reside in the gut can help to block microbial infection. A group of bacteria that lives in the human gut has been identified that can consume a nutrient needed by pathogenic bacteria. Depletion of the molecule gluconate halts gut colonization by a pathogen. [ABSTRACT FROM AUTHOR]

The human brain is usually considered to be beyond the reach of most immune cells. However, analysis of people who have brain tumours has revealed tumour-targeting T cells of the immune system in skull bones near the cancer site.Tumour-targeting T cells found in skull bones near human brain cancer. [ABSTRACT FROM AUTHOR]

Boosting the heart’s natural countermeasures against poor function is one way to treat heart failure, but existing therapies need to be given frequently. An antibody with enduring effects could offer a solution.Enhancing hormone activity enduringly lowers blood pressure. [ABSTRACT FROM AUTHOR]

The immune-signalling protein TNF has an essential role in inflammatory responses. Two people who were found to have no functional TNF are surprisingly healthy and able to fend off most infections, but are susceptible to tuberculosis. Insights about the immune system of people who lack a defence protein. [ABSTRACT FROM AUTHOR]

Cancer-promoting mutations are common in healthy tissue but rarely lead to tumour formation. A study of the mouse mammary gland reveals three protective mechanisms that limit the ability of cells to give rise to cancer.Three protective mechanisms limit the ability of cells to form a tumour. [ABSTRACT FROM AUTHOR]

Implants and other technologies that decode neural activity can restore people’s abilities to move and speak — and help researchers to understand how the brain works. [ABSTRACT FROM AUTHOR]

After decades of frustration and failed attempts, scientists might finally be on the cusp of developing therapies to restore immune ‘tolerance’ in conditions such as diabetes, lupus and multiple sclerosis. [ABSTRACT FROM AUTHOR]

Scientists are trying to work out how to balance potency with toxicity and tackle the cost of next-generation therapeutics. [ABSTRACT FROM AUTHOR]

Genetic sequencing of human kidney cancers worldwide has revealed associations between geographical locations and specific mutation patterns, indicating exposure to known and unknown mutation-promoting agents.Cancer-sequence signatures point to unknown mutation-promoting agents. [ABSTRACT FROM AUTHOR]

Cells grown on a 3D scaffold have generated a ‘mini-colon’ that mimics key features of the organ. Controlled expression of cancer-associated genes in the system offers a way to examine tumour formation over space and time.Experimental system to examine tumour formation over space and time. [ABSTRACT FROM AUTHOR]

Understanding the factors that drive formation of particular types of cancer can aid efforts to develop better diagnostics or treatments. The identification of a bacterial subspecies with a connection to colon cancer has clinical relevance. Revised view of the bacterial subspecies associated with colon cancer. [ABSTRACT FROM AUTHOR]

The treatment, called NexCAR19, raises hopes that this transformative class of medicine will become more readily available in low- and middle-income countries. [ABSTRACT FROM AUTHOR]

Early results from clinical trial show that the antiviral drug tecovirimat is no better than placebo against the clade I virus type. [ABSTRACT FROM AUTHOR]

It emerges from a study of human cells that smoking can influence certain immune responses to the same extent as can age or genetics. Smoking can alter the immune system in ways that persist long after quitting the habit.Smoking alters the immune system in ways that persist after quitting. [ABSTRACT FROM AUTHOR]

Researchers say their artificial-intelligence system could help to democratize medicine. [ABSTRACT FROM AUTHOR]

Technique wipes away tags on DNA that must be reprogrammed during development of reproductive cells. [ABSTRACT FROM AUTHOR]

Pathologist whose finding that viruses can trigger tumours in humans transformed medical research. [ABSTRACT FROM AUTHOR]