The 25-km-long section of the San Andreas fault near Parkfield, California ruptured in similar magnitude-6 earthquakes in 1881, 1901, 1922, 1934 and 1966. On the basis of a number of lines of seismological evidence, a section of the San Andreas fault, now termed the Parkfield preparation zone, has been identified as the locus of the next Parkfield earthquake1,3. Here we describe coincident changes in surface creep rates and deep seismicity near the Parkfield preparation zone following the 2 May 1983 Coalinga earthquake, and suggest that both respond to the same stimuli. These changes were concentrated near the point of initiation of the magnitude-6 characteristic Parkfield earthquakes, lending credence to the hypothesis that this section of the San Andreas fault is characterized by a unique set of physical properties4–6 which make it ideal for earthquake prediction studies and which may also be useful for identifying hypocentral regions in other areas.