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1. Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

Author

Cullen, Peter J., Hsuan, J. Justin, Truong, Oanh, Letcher, Andrew J., Jackson, Trevor R., Dawson, Alan P., and Irvine, Robin F.

Subjects
G proteins -- Research, Inositol phosphates -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A protein receptor for inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4, has been purified from stimulated cell tissue that specifically binds Ins(1,4,5)P3. The protein shows a specificity for Ins(1,3,4,5)P4's isomeric configuration and has a high affinity for it. The behavior the protein and its in vitro GAP activity against Ras and Rap indicate a GTPase-activating protein of the GAP1 family while Ras GAP activity is stimulated by Ins(1,3,4,5)P4 and inhibited by phospholipids.

Published
1995

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