1. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
- Author
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David Cosman, Dirk M. Anderson, Mark Teepe, Laurent J. Galibert, Eugene Maraskovsky, William L. Billingsley, Robert F. DuBose, Eileen R. Roux, William C. Dougall, and Mark E. Tometsko
- Subjects
T-Lymphocytes ,T cell ,CD40 Ligand ,Molecular Sequence Data ,Antigen presentation ,Ligands ,Transfection ,Receptors, Tumor Necrosis Factor ,Cell Line ,Mice ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Cells, Cultured ,Membrane Glycoproteins ,Multidisciplinary ,CD40 ,Chromosomes, Human, Pair 13 ,Receptor Activator of Nuclear Factor-kappa B ,Sequence Homology, Amino Acid ,biology ,Follicular dendritic cells ,CLEC7A ,RANK Ligand ,Chromosome Mapping ,Membrane Proteins ,Dendritic Cells ,Dendritic cell ,Cell biology ,medicine.anatomical_structure ,RANKL ,Immunology ,biology.protein ,Interleukin 12 ,Carrier Proteins ,Chromosomes, Human, Pair 18 - Abstract
Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity. Several members of the tumour necrosis factor receptor (TNFR) superfamily are integral to the regulation of the immune response. These structurally related proteins modulate cellular functions ranging from proliferation and differentiation to inflammation and cell survival or deaths. The functional activity of dendritic cells is greatly increased by signalling through the TNFR family member CD40. Here we report the characterization of RANK (for receptor activator of NF-kappaB), a new member of the TNFR family derived from dendritic cells, and the isolation of a RANK ligand (RANKL) by direct expression screening. RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, and increases the survival of RANK+ T cells generated with interleukin-4 and transforming growth factor (TGF)-beta. Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.
- Published
- 1997
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