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4 results on '"Sun, Aihua"'

1. π-HuB: the proteomic navigator of the human body

Author

He, Fuchu, Aebersold, Ruedi, Baker, Mark S., Bian, Xiuwu, Bo, Xiaochen, Chan, Daniel W., Chang, Cheng, Chen, Luonan, Chen, Xiangmei, Chen, Yu-Ju, Cheng, Heping, Collins, Ben C., Corrales, Fernando, Cox, Jürgen, E, Weinan, Van Eyk, Jennifer E., Fan, Jia, Faridi, Pouya, Figeys, Daniel, Gao, George Fu, Gao, Wen, Gao, Zu-Hua, Goda, Keisuke, Goh, Wilson Wen Bin, Gu, Dongfeng, Guo, Changjiang, Guo, Tiannan, He, Yuezhong, Heck, Albert J. R., Hermjakob, Henning, Hunter, Tony, Iyer, Narayanan Gopalakrishna, Jiang, Ying, Jimenez, Connie R., Joshi, Lokesh, Kelleher, Neil L., Li, Ming, Li, Yang, Lin, Qingsong, Liu, Cui Hua, Liu, Fan, Liu, Guang-Hui, Liu, Yansheng, Liu, Zhihua, Low, Teck Yew, Lu, Ben, Mann, Matthias, Meng, Anming, Moritz, Robert L., Nice, Edouard, Ning, Guang, Omenn, Gilbert S., Overall, Christopher M., Palmisano, Giuseppe, Peng, Yaojin, Pineau, Charles, Poon, Terence Chuen Wai, Purcell, Anthony W., Qiao, Jie, Reddel, Roger R., Robinson, Phillip J., Roncada, Paola, Sander, Chris, Sha, Jiahao, Song, Erwei, Srivastava, Sanjeeva, Sun, Aihua, Sze, Siu Kwan, Tang, Chao, Tang, Liujun, Tian, Ruijun, Vizcaíno, Juan Antonio, Wang, Chanjuan, Wang, Chen, Wang, Xiaowen, Wang, Xinxing, Wang, Yan, Weiss, Tobias, Wilhelm, Mathias, Winkler, Robert, Wollscheid, Bernd, Wong, Limsoon, Xie, Linhai, Xie, Wei, Xu, Tao, Xu, Tianhao, Yan, Liying, Yang, Jing, Yang, Xiao, Yates, John, Yun, Tao, Zhai, Qiwei, Zhang, Bing, Zhang, Hui, Zhang, Lihua, Zhang, Lingqiang, Zhang, Pingwen, Zhang, Yukui, Zheng, Yu Zi, Zhong, Qing, and Zhu, Yunping

Abstract

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual’s body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called π-HuB (proteomic navigator of the human body). The aim of the π-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors.

Published
2024
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2. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

Author

Jiang, Ying, Sun, Aihua, Zhao, Yang, Ying, Wantao, Sun, Huichuan, Yang, Xinrong, and Xing, Baocai

Subjects
Physiological aspects, Care and treatment, Proteomics, Hepatocellular carcinoma -- Physiological aspects -- Care and treatment, Cancer research, Homeostasis, Cancer, Virus diseases, Tumors, Carcinoma, Surgery, Hepatitis B, Infection, Steroids (Organic compounds), Criminal investigation, Hepatitis B virus, Medical schools
Abstract

Author(s): Ying Jiang [sup.1] , Aihua Sun [sup.1] , Yang Zhao [sup.1] [sup.2] , Wantao Ying [sup.1] , Huichuan Sun [sup.3] , Xinrong Yang [sup.3] , Baocai Xing [sup.4] , [...], Hepatocellular carcinoma is the third leading cause of deaths from cancer worldwide. Infection with the hepatitis B virus is one of the leading risk factors for developing hepatocellular carcinoma, particularly in East Asia.sup.1. Although surgical treatment may be effective in the early stages, the five-year overall rate of survival after developing this cancer is only 50-70%.sup.2. Here, using proteomic and phospho-proteomic profiling, we characterize 110 paired tumour and non-tumour tissues of clinical early-stage hepatocellular carcinoma related to hepatitis B virus infection. Our quantitative proteomic data highlight heterogeneity in early-stage hepatocellular carcinoma: we used this to stratify the cohort into the subtypes S-I, S-II and S-III, each of which has a different clinical outcome. S-III, which is characterized by disrupted cholesterol homeostasis, is associated with the lowest overall rate of survival and the greatest risk of a poor prognosis after first-line surgery. The knockdown of sterol O-acyltransferase 1 (SOAT1)--high expression of which is a signature specific to the S-III subtype--alters the distribution of cellular cholesterol, and effectively suppresses the proliferation and migration of hepatocellular carcinoma. Finally, on the basis of a patient-derived tumour xenograft mouse model of hepatocellular carcinoma, we found that treatment with avasimibe, an inhibitor of SOAT1, markedly reduced the size of tumours that had high levels of SOAT1 expression. The proteomic stratification of early-stage hepatocellular carcinoma presented in this study provides insight into the tumour biology of this cancer, and suggests opportunities for personalized therapies that target it. A subtype of early-stage hepatocellular carcinoma characterized by disrupted cholesterol homeostasis and associated with a poor prognosis responds to treatment with the SOAT1 inhibitor avasimibe in a patient-derived xenograft mouse model.

Published
2019
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3. Author Correction: π-HuB: the proteomic navigator of the human body

Author

He, Fuchu, Aebersold, Ruedi, Baker, Mark S., Bian, Xiuwu, Bo, Xiaochen, Chan, Daniel W., Chang, Cheng, Chen, Luonan, Chen, Xiangmei, Chen, Yu-Ju, Cheng, Heping, Collins, Ben C., Corrales, Fernando, Cox, Jürgen, E, Weinan, Van Eyk, Jennifer E., Fan, Jia, Faridi, Pouya, Figeys, Daniel, Gao, George Fu, Gao, Wen, Gao, Zu-Hua, Goda, Keisuke, Goh, Wilson Wen Bin, Gu, Dongfeng, Guo, Changjiang, Guo, Tiannan, He, Yuezhong, Heck, Albert J. R., Hermjakob, Henning, Hunter, Tony, Iyer, Narayanan Gopalakrishna, Jiang, Ying, Jimenez, Connie R., Joshi, Lokesh, Kelleher, Neil L., Li, Ming, Li, Yang, Lin, Qingsong, Liu, Cui Hua, Liu, Fan, Liu, Guang-Hui, Liu, Yansheng, Liu, Zhihua, Low, Teck Yew, Lu, Ben, Mann, Matthias, Meng, Anming, Moritz, Robert L., Nice, Edouard, Ning, Guang, Omenn, Gilbert S., Overall, Christopher M., Palmisano, Giuseppe, Peng, Yaojin, Pineau, Charles, Poon, Terence Chuen Wai, Purcell, Anthony W., Qiao, Jie, Reddel, Roger R., Robinson, Phillip J., Roncada, Paola, Sander, Chris, Sha, Jiahao, Song, Erwei, Srivastava, Sanjeeva, Sun, Aihua, Sze, Siu Kwan, Tang, Chao, Tang, Liujun, Tian, Ruijun, Vizcaíno, Juan Antonio, Wang, Chanjuan, Wang, Chen, Wang, Xiaowen, Wang, Xinxing, Wang, Yan, Weiss, Tobias, Wilhelm, Mathias, Winkler, Robert, Wollscheid, Bernd, Wong, Limsoon, Xie, Linhai, Xie, Wei, Xu, Tao, Xu, Tianhao, Yan, Liying, Yang, Jing, Yang, Xiao, Yates, John, Yun, Tao, Zhai, Qiwei, Zhang, Bing, Zhang, Hui, Zhang, Lihua, Zhang, Lingqiang, Zhang, Pingwen, Zhang, Yukui, Zheng, Yu Zi, Zhong, Qing, and Zhu, Yunping

Published
2024
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4. Author Correction: π-HuB: the proteomic navigator of the human body.

Author

He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q, and Zhu Y

Published
2025
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