1. RIP3 mediates the embryonic lethality of caspase-8-deficient mice
- Author
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Kaiser, William J., Upton, Jason W., Long, Alyssa B., Livingston-Rosanoff, Devon, Daley-Bauer, Lisa P., Hakem, Razqallah, Caspary, Tamara, and Mocarski, Edward S.
- Subjects
Proteases -- Physiological aspects -- Genetic aspects -- Research ,Embryonic development -- Genetic aspects -- Research -- Physiological aspects ,Apoptosis -- Physiological aspects -- Genetic aspects -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Apoptosis and necroptosis are complementary pathways controlled by common signalling adaptors, kinases and proteases; among these, caspase-8 (Casp8) is critical for death receptor-induced apoptosis. This caspase has also been implicated [...]
- Published
- 2011
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