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Your search keyword '"VOUSDEN, KAREN H."' showing total 20 results
Start Over Author "VOUSDEN, KAREN H." Journal nature
20 results on '"VOUSDEN, KAREN H."'

1. The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Author

Zani, Fabio, primary, Blagih, Julianna, additional, Gruber, Tim, additional, Buck, Michael D., additional, Jones, Nicholas, additional, Hennequart, Marc, additional, Newell, Clare L., additional, Pilley, Steven E., additional, Soro-Barrio, Pablo, additional, Kelly, Gavin, additional, Legrave, Nathalie M., additional, Cheung, Eric C., additional, Gilmore, Ian S., additional, Gould, Alex P., additional, Garcia-Caceres, Cristina, additional, and Vousden, Karen H., additional

Published
2023
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2. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Author

Maddocks, Oliver D.K., Berkers, Celia R., Mason, Susan M., Zheng, Liang, Blyth, Karen, Gottlieb, Eyal, and Vousden, Karen H.

Subjects
Serine -- Physiological aspects -- Health aspects, Tumor suppressor genes -- Physiological aspects -- Health aspects, Cancer cells -- Physiological aspects -- Health aspects, Oxidative stress -- Physiological aspects -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known as TP53) [...]

Published
2013
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3. Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Author

Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnes C.L., Maddocks, Oliver D.K., Chokkathukalam, Achuthanunni, Coyle, Joseph E., Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O'Reilly, Marc, and Gottlieb, Eyal

Subjects
Cell proliferation -- Research, Biosynthesis -- Research, Serine -- Properties -- Research, Pyruvate kinase -- Observations -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and proliferation (1). Specifically, they over-express the M2 isoform of the tightly regulated enzyme pyruvate kinase (PKM2), [...]

Published
2012
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5. Proliferation, cell cycle and apoptosis in cancer

Author

Evan, Gerard I. and Vousden, Karen H.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Gerard I. Evan [1]; Karen H. Vousden [2] Since its inception, the study of the molecular basis of cancer has carried with it the promise of more refined, more [...]

Published
2001
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6. Role for the p53 homologue p73 in E2F-1-induced apoptosis

Author

Irwin, Meredith, Marin, Maria Carmen, Phillips, Andrew C., Seelan, Ratnam S., Smith, David I., Liu, Wanguo, Flores, Elsa R., Tsai, Kenneth Y., Jacks, Tyler, Vousden, Karen H., and Kaelin Jr, William G.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Meredith Irwin [1]; Maria Carmen Marin [1]; Andrew C. Phillips [2]; Ratnam S. Seelan [3]; David I. Smith [3]; Wanguo Liu [3]; Elsa R. Flores [4, 5]; Kenneth Y. [...]

Published
2000
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7. Role of NF-κB in p53-mediated programmed cell death

Author

Ryan, Kevin M., Ernst, Mary K., Rice, Nancy R., and Vousden, Karen H.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Kevin M. Ryan; Mary K. Ernst; Nancy R. Rice; Karen H. Vousden (corresponding author) The tumour suppressor p53 inhibits cell growth through activation of cell-cycle arrest and apoptosis [1], [...]

Published
2000
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8. Regulation of p53 stability by Mdm2

Author

Kubbutat, Michael H.G., Jones, Stephen N., and Vousden, Karen H.

Subjects
Tumor suppressor genes -- Research, Proteins -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

An interaction between the p53 tumor-suppressor protein and the Mdm2 oncoprotein is needed to ensure normal cell growth and development. In this process, Mdm2 controls the apoptic functions and cell-cycle arrest in p53. In addition, the enhanced proteasome-dependent degradation created by the interaction results to a reduction in the number of p53 proteins. P53 concentrations in normal cells are thereby reduced.

Published
1997

12. Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Author

Maddocks, Oliver D. K., Athineos, Dimitris, Cheung, Eric C., Lee, Pearl, Zhang, Tong, van den Broek, Niels J. F., Mackay, Gillian M., Labuschagne, Christiaan F., Gay, David, Kruiswijk, Flore, Blagih, Julianna, Vincent, David F., Campbell, Kirsteen J., Ceteci, Fatih, Sansom, Owen J., Blyth, Karen, and Vousden, Karen H.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Oliver D. K. Maddocks; Dimitris Athineos; Eric C. Cheung; Pearl Lee; Tong Zhang; Niels J. F. van den Broek; Gillian M. Mackay; Christiaan F. Labuschagne; David Gay; Flore Kruiswijk; [...]

Published
2017
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13. Erratum: Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Author

Maddocks, Oliver D. K., primary, Athineos, Dimitris, additional, Cheung, Eric C., additional, Lee, Pearl, additional, Zhang, Tong, additional, van den Broek, Niels J. F., additional, Mackay, Gillian M., additional, Labuschagne, Christiaan F., additional, Gay, David, additional, Kruiswijk, Flore, additional, Blagih, Julianna, additional, Vincent, David F., additional, Campbell, Kirsteen J., additional, Ceteci, Fatih, additional, Sansom, Owen J., additional, Blyth, Karen, additional, and Vousden, Karen H., additional

Published
2017
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14. Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Author

Maddocks, Oliver D. K., primary, Athineos, Dimitris, additional, Cheung, Eric C., additional, Lee, Pearl, additional, Zhang, Tong, additional, van den Broek, Niels J. F., additional, Mackay, Gillian M., additional, Labuschagne, Christiaan F., additional, Gay, David, additional, Kruiswijk, Flore, additional, Blagih, Julianna, additional, Vincent, David F., additional, Campbell, Kirsteen J., additional, Ceteci, Fatih, additional, Sansom, Owen J., additional, Blyth, Karen, additional, and Vousden, Karen H., additional

Published
2017
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15. Correction: Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Author

Chaneton, Barbara, primary, Hillmann, Petra, additional, Zheng, Liang, additional, Martin, Agnés C. L., additional, Maddocks, Oliver D. K., additional, Chokkathukalam, Achuthanunni, additional, Coyle, Joseph E., additional, Jankevics, Andris, additional, Holding, Finn P., additional, Vousden, Karen H., additional, Frezza, Christian, additional, O’Reilly, Marc, additional, and Gottlieb, Eyal, additional

Published
2013
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20. Activation of c-Ha-ras-1 proto-oncogene by in vitromodification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

Author

Marshall, Christopher J., Vousden, Karen H., and Phillips, David H.

Abstract

Chemical carcinogenesis generally proceeds via the formation of strongly electrophilic reactants, termed ultimate carcinogens1. The observation that many ultimate carcinogens are potent mutagens2and the results of studies on the covalent binding of carcinogens to cellular macromolecules3–5suggest that tumour initiation results from mutations arising from the binding of ultimate carcinogens to DNA. Recently, gene transfer experiments have shown that some tumours contain activated oncogenes which are members of the rasgene family (reviewed in refs 6. 7) and which differ by single base pair substitutions from their non-transforming counterparts, the proto-oncogenes (see, for example, refs 8–11). Here we have used clones of the c-Ha-ras-1 proto-oncogene to show that reaction in vitrowith an ultimate carcinogen generates a transforming oncogene when the modified DNA is introduced into NIH 3T3 cells. As DNA is the only cellular macromolecule present in the reactions, our experiments also show that reaction of an ultimate carcinogen with DNA alone can lead to the induction of mutations in mammalian cells.

Published
1984
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