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1. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Author

Steffan, Joan S., Bodai, Laszlo, Pallos, Judit, Poelman, Marnix, McCampbell, Alexander, Apostol, Barbara L., Kazantsev, Alexsey, Schmidt, Emily, Ya-Zhen Zhu, Greenwald, Marilee, Kurokawa, Riki, Housman, David E., Jackson, George R., Marsh, J. Lawrence, and Thompson, Leslie M.

Subjects
HUNTINGTON disease, GLUTAMINE, HISTONE deacetylase
Abstract

Investigates the molecular basis in the development of Huntington's disease. Expansion of a repeated sequence of the amino acid glutamine in abnormal protein huntingtin; Arrest of degeneration through the action of histone deacetylase inhibitors; Potential of including inhibitors in therapy.

Published
2001
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