1. Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection
- Author
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Gokhan Tut, Tara Lancaster, Megan S. Butler, Panagiota Sylla, Eliska Spalkova, David Bone, Nayandeep Kaur, Christopher Bentley, Umayr Amin, Azar T. Jadir, Samuel Hulme, Morenike Ayodel, Alexander C. Dowell, Hayden Pearce, Jianmin Zuo, Sandra Margielewska-Davies, Kriti Verma, Samantha Nicol, Jusnara Begum, Elizabeth Jinks, Elif Tut, Rachel Bruton, Maria Krutikov, Madhumita Shrotri, Rebecca Giddings, Borscha Azmi, Chris Fuller, Aidan Irwin-Singer, Andrew Hayward, Andrew Copas, Laura Shallcross, and Paul Moss
- Subjects
Aging ,Neuroscience (miscellaneous) ,Geriatrics and Gerontology - Abstract
We studied humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 152 long-term care facility staff and 124 residents over a prospective 4-month period shortly after the first wave of infection in England. We show that residents of long-term care facilities developed high and stable levels of antibodies against spike protein and receptor-binding domain. Nucleocapsid-specific responses were also elevated but waned over time. Antibodies showed stable and equivalent levels of functional inhibition against spike-angiotensin-converting enzyme 2 binding in all age groups with comparable activity against viral variants of concern. SARS-CoV-2 seropositive donors showed high levels of antibodies to other beta-coronaviruses but serostatus did not impact humoral immunity to influenza or other respiratory syncytial viruses. SARS-CoV-2-specific cellular responses were similar across all ages but virus-specific populations showed elevated levels of activation in older donors. Thus, survivors of SARS-CoV-2 infection show a robust and stable immunity against the virus that does not negatively impact responses to other seasonal viruses.
- Published
- 2022
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