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The scientific ecosystem relies on citation-based metrics that provide only imperfect, inconsistent and easily manipulated measures of research quality. Here we describe DELPHI (Dynamic Early-warning by Learning to Predict High Impact), a framework that provides an early-warning signal for 'impactful' research by autonomously learning high-dimensional relationships among features calculated across time from the scientific literature. We prototype this framework and deduce its performance and scaling properties on time-structured publication graphs from 1980 to 2019 drawn from 42 biotechnology-related journals, including over 7.8 million individual nodes, 201 million relationships and 3.8 billion calculated metrics. We demonstrate the framework's performance by correctly identifying 19/20 seminal biotechnologies from 1980 to 2014 via a blinded retrospective study and provide 50 research papers from 2018 that DELPHI predicts will be in the top 5% of time-rescaled node centrality in the future. We propose DELPHI as a tool to aid in the construction of diversified, impact-optimized funding portfolios. Biotechnology-related papers predicted to be of long-term impact are identified in a machine learning framework (DELPHI) that analyzes relationships among a range of features from the scientific literature over time. [ABSTRACT FROM AUTHOR]

Argues that media coverage of scientific discoveries in the absence of corroboration in a peer-reviewed scientific paper not only compromises scientific discourse, but also acts on the public perception of science. Examples that highlight the problem of media sensationalization and hyperbole resulting premature release of scientific findings; Reasons why scientific findings should never be covered by the popular media before publication in a peer-reviewed paper.

Comments on Neil Stewart's article 'Press before paper - when science and media collide,' published in the volume 21, 2003 issue of the journal 'Nature Biotechnology. Analysis of the food aid crisis in Africa; Effects of transgenes on wild populations; Dangers of discussing scientific results with the media before publishing them in peer-reviewed literature.

The article focuses on the Minimum Information About a Microarray Experiment proposed by the Microarray Gene Expression Data Society. The adoption of these guidelines by journals has prompted the submission of microarray data sets to major public repositories such as the ArrayExpress in Europe and the Gene Expression Omnibus in the U.S. ArrayExpress designed submission tools to encourage compliance, while ArrayExpress curators assist submitters in providing the necessary information.

Focuses on the report produced by the Committee on Industry, External Trade, Research, and Energy regarding biotechnological methods to improve performance in biotechnology field in Europe. Suggestions proposed by the committee; Needs to create seed-stage financial resources; Response of European Parliament European Commission on the report; Concern regarding the prospects of the report.

The article informs that Sao Paulo, Brazil-based FuturaGene PLC, forestry company will share yield-enhancement traits used in woody crops with a nonprofit research institute to improve the flexibility of staple crops grown in arid and semiarid regions of Asia, Africa and Brazil.

The article discusses how the journal helps many of its authors to achieve commercial success. "Nature Biotechnology" believes that they bring research out of the laboratory and into the marketplace. Many of these authors were asked to assess how their work had been commercialized over the past ten years through the number of respondents. Getting a product into the marketplace is just one measure of a successful research program and conversely, the work featured in papers which received few citations can sometimes turn into commercial gold.

Studies the role of gibberellin in plant growth with reference to aspen trees containing enzyme for gibberellin biosynthesis.

Critiques the peer-reviewed scientific correspondence paper published in the May 1999 issue of the journal 'Nature' which indicated that transgenic pollens kills larvae of the monarch butterfly. Arguments that forced feeding of the potentially toxic compound to larvae does not affect the pollen; Criticism on the quantification of the research experiments; Possible effect of the Bt corn on non target organisms.

Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic? [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

Coronavirus is instigating new thinking in diagnostics, such as face masks that can detect viruses on a wearer's breath or paper-based microfluidics for pathogen identification in low-resource settings. [ABSTRACT FROM AUTHOR]

A reply by the authors to a letter to the editor on their article "MAQC papers over the cracks," is presented.

A letter to the editor in response to the papers on MicroArray Quality Control (MAQC) study by Shi is presented.

The retraction of >30 falsified studies by Anversa et al. has had a disheartening impact on the cardiac cell therapeutics field. The premise of heart muscle regeneration by the transdifferentiation of bone marrow cells or putative adult resident cardiac progenitors has been largely disproven. Over the past 18 years, a generation of physicians and scientists has lost years chasing these studies, and patients have been placed at risk with little scientific grounding. Funding agencies invested hundreds of millions of dollars in irreproducible work, and both academic institutions and the scientific community ignored troubling signals over a decade of questionable work. Our collective retrospective analysis identifies preventable problems at the level of the editorial and peer-review process, funding agencies and academic institutions. This Perspective provides a chronology of the forces that led to this scientific debacle, integrating direct knowledge of the process. We suggest a science-driven path forward that includes multiple novel approaches to the problem of heart muscle regeneration. Chien et al. reflect on lessons learned following the recent announcement that 31 papers from the Anversa laboratory on cardiac cell therapy are being retracted. [ABSTRACT FROM AUTHOR]

Many viral surface glycoproteins and cell surface receptors are homo-oligomers, and thus can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits together. The adaptive immune system cannot generally employ this strategy since the individual antibody binding sites are not arranged with appropriate geometry to simultaneously engage multiple sites in a single target homo-oligomer. We describe a general strategy for the computational design of homo-oligomeric protein assemblies with binding functionality precisely matched to homo-oligomeric target sites. In the first step, a small protein is designed that binds a single site on the target. In the second step, the designed protein is assembled into a homo-oligomer such that the designed binding sites are aligned with the target sites. We use this approach to design high-avidity trimeric proteins that bind influenza A hemagglutinin (HA) at its conserved receptor binding site. The designed trimers can both capture and detect HA in a paper-based diagnostic format, neutralizes influenza in cell culture, and completely protects mice when given as a single dose 24 h before or after challenge with influenza. [ABSTRACT FROM AUTHOR]

Presents an analysis of the patent and scientific literature on single-nucleotide polymorphisms (SNP). Information about papers published from 1987 to 2001; Categorization of authors of SNP papers; Region leading in the area of SNP research.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

The article focuses on a research paper published in the journal "Nature" which reveals sequencing of the tomato genome in the evolution of fruit size, texture, flavor and nutritional quality. The paper also reports genome sequences of cultivated tomato (Solanum lycopersicum) and its closest wild relative (Solanum pimpinellifolium) and reveals introgressions from wild relatives that prevent various agriculturally important traits.

The authors comment on G. L. Boulting's paper that compares differentiation behavior across a set of human induced pluripotent stem cells (iPSC) and embryonic stem cell (ESC) lines. They say that Boulting's paper suggests that the mean differentiation performance of human iPSC and ESC lines cannot be distinguished and that simple changes in culture conditions can rescue poorly performing iPSC lines. They also discussed the questions raised by the advent of iPSC technology about the reversibility and molecular control of differentiated cell fates.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]