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The article offers information regarding the trends in biotechnology literature in 2005. The number of output of biotech papers of the European Union outnumbered the U.S. scientists. South Korea was replaced by Belgium in the top 15 countries in terms of biotech paper output. It was also revealed that most researches deal in the field of metabolomics and nanotechnology.

The article presents data related to biotechnology research papers in the U.S. The US remains the most productive country in terms of biotech-related papers. But numbers of papers from the European Union surpassed the US last year (with Germany and the UK ahead of most EU countries); elsewhere, Korea, China and Japan also publish frequently. Some of the top cited papers, published in different journals, by field are: RNAi--Systematic functional analysis of the Caenorhabditis elegans genome using RNAi; Gene therapy--LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X2 and Nuclear transfer--Derivation of oocytes from mouse embryonic stem cells.

The authors contend that increased data sharing, transparency, openness and academic rewards for team and multidisciplinary behavior are important aspects in developing a productive and vibrant biomedical discovery establishment in the U.S. in March 2011. They say that historical trends are directed to steady progress towards collaboration and openness, which include the widening fraction of open-access publications with continuously increasing impact. They also discuss the challenges in achieving integrative medicine that leverages different data types.