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9 results on '"A Kleger"'

1. Three-dimensional printing of photonic colloidal glasses into objects with isotropic structural color

Author

Ahmet F. Demirörs, Erik Poloni, Maddalena Chiesa, Fabio L. Bargardi, Marco R. Binelli, Wilhelm Woigk, Lucas D. C. de Castro, Nicole Kleger, Fergal B. Coulter, Alba Sicher, Henning Galinski, Frank Scheffold, and André R. Studart

Subjects
Science
Abstract

There is a growing interest in mimicking structural color in natural systems aiming for sustainable and long-lasting color. Here the authors report a platform for three-dimensional printing assembly of colloidal particles of silica and carbon that have programmable structural color.

Published
2022
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2. Spike residue 403 affects binding of coronavirus spikes to human ACE2

Author

Fabian Zech, Daniel Schniertshauer, Christoph Jung, Alexandra Herrmann, Arne Cordsmeier, Qinya Xie, Rayhane Nchioua, Caterina Prelli Bozzo, Meta Volcic, Lennart Koepke, Janis A. Müller, Jana Krüger, Sandra Heller, Steffen Stenger, Markus Hoffmann, Stefan Pöhlmann, Alexander Kleger, Timo Jacob, Karl-Klaus Conzelmann, Armin Ensser, Konstantin M. J. Sparrer, and Frank Kirchhoff

Subjects
Science
Abstract

The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses.

Published
2021
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3. IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Author

Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lennart Koepke, Jana Krüger, Desiree Schütz, Sandra Heller, Christina M. Stürzel, Dorota Kmiec, Carina Conzelmann, Janis Müller, Fabian Zech, Elisabeth Braun, Rüdiger Groß, Lukas Wettstein, Tatjana Weil, Johanna Weiß, Federica Diofano, Armando A. Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M. Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M. J. Sparrer, and Frank Kirchhoff

Subjects
Science
Abstract

IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry.

Published
2021
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4. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Author

Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B. Ruiz-Blanco, Markus Hoffmann, Konstantin M. J. Sparrer, Stefan Pöhlmann, Elsa Sanchez-Garcia, Frank Kirchhoff, Manfred Frick, and Jan Münch

Subjects
Science
Abstract

Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

Published
2021
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5. Three-dimensional printing of photonic colloidal glasses into objects with isotropic structural color

Author

Demirörs, Ahmet F., primary, Poloni, Erik, additional, Chiesa, Maddalena, additional, Bargardi, Fabio L., additional, Binelli, Marco R., additional, Woigk, Wilhelm, additional, de Castro, Lucas D. C., additional, Kleger, Nicole, additional, Coulter, Fergal B., additional, Sicher, Alba, additional, Galinski, Henning, additional, Scheffold, Frank, additional, and Studart, André R., additional

Published
2022
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6. Spike residue 403 affects binding of coronavirus spikes to human ACE2

Author

Zech, Fabian, primary, Schniertshauer, Daniel, additional, Jung, Christoph, additional, Herrmann, Alexandra, additional, Cordsmeier, Arne, additional, Xie, Qinya, additional, Nchioua, Rayhane, additional, Prelli Bozzo, Caterina, additional, Volcic, Meta, additional, Koepke, Lennart, additional, Müller, Janis A., additional, Krüger, Jana, additional, Heller, Sandra, additional, Stenger, Steffen, additional, Hoffmann, Markus, additional, Pöhlmann, Stefan, additional, Kleger, Alexander, additional, Jacob, Timo, additional, Conzelmann, Karl-Klaus, additional, Ensser, Armin, additional, Sparrer, Konstantin M. J., additional, and Kirchhoff, Frank, additional

Published
2021
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7. IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Author

Prelli Bozzo, Caterina, primary, Nchioua, Rayhane, additional, Volcic, Meta, additional, Koepke, Lennart, additional, Krüger, Jana, additional, Schütz, Desiree, additional, Heller, Sandra, additional, Stürzel, Christina M., additional, Kmiec, Dorota, additional, Conzelmann, Carina, additional, Müller, Janis, additional, Zech, Fabian, additional, Braun, Elisabeth, additional, Groß, Rüdiger, additional, Wettstein, Lukas, additional, Weil, Tatjana, additional, Weiß, Johanna, additional, Diofano, Federica, additional, Rodríguez Alfonso, Armando A., additional, Wiese, Sebastian, additional, Sauter, Daniel, additional, Münch, Jan, additional, Goffinet, Christine, additional, Catanese, Alberto, additional, Schön, Michael, additional, Boeckers, Tobias M., additional, Stenger, Steffen, additional, Sato, Kei, additional, Just, Steffen, additional, Kleger, Alexander, additional, Sparrer, Konstantin M. J., additional, and Kirchhoff, Frank, additional

Published
2021
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8. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Author

Wettstein, Lukas, primary, Weil, Tatjana, additional, Conzelmann, Carina, additional, Müller, Janis A., additional, Groß, Rüdiger, additional, Hirschenberger, Maximilian, additional, Seidel, Alina, additional, Klute, Susanne, additional, Zech, Fabian, additional, Prelli Bozzo, Caterina, additional, Preising, Nico, additional, Fois, Giorgio, additional, Lochbaum, Robin, additional, Knaff, Philip Maximilian, additional, Mailänder, Volker, additional, Ständker, Ludger, additional, Thal, Dietmar Rudolf, additional, Schumann, Christian, additional, Stenger, Steffen, additional, Kleger, Alexander, additional, Lochnit, Günter, additional, Mayer, Benjamin, additional, Ruiz-Blanco, Yasser B., additional, Hoffmann, Markus, additional, Sparrer, Konstantin M. J., additional, Pöhlmann, Stefan, additional, Sanchez-Garcia, Elsa, additional, Kirchhoff, Frank, additional, Frick, Manfred, additional, and Münch, Jan, additional

Published
2021
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9. Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Author

Russell, Ronan, primary, Perkhofer, Lukas, additional, Liebau, Stefan, additional, Lin, Qiong, additional, Lechel, André, additional, Feld, Fenja M, additional, Hessmann, Elisabeth, additional, Gaedcke, Jochen, additional, Güthle, Melanie, additional, Zenke, Martin, additional, Hartmann, Daniel, additional, von Figura, Guido, additional, Weissinger, Stephanie E, additional, Rudolph, Karl-Lenhard, additional, Möller, Peter, additional, Lennerz, Jochen K, additional, Seufferlein, Thomas, additional, Wagner, Martin, additional, and Kleger, Alexander, additional

Published
2015
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