Search

Your search keyword '"Aleksandra Arsic"' showing total 2 results
Start Over Author "Aleksandra Arsic" Journal nature communications
2 results on '"Aleksandra Arsic"'

1. Minimal genetically encoded tags for fluorescent protein labeling in living neurons

Author

Aleksandra Arsić, Cathleen Hagemann, Nevena Stajković, Timm Schubert, and Ivana Nikić-Spiegel

Subjects
Science
Abstract

Site-specific labelling of proteins can be performed with unnatural amino acids combined with bioorthogonal click chemistry. Here the authors establish this in living neurons, using neurofilament light chain; they show combination with CRISPR/Cas9 engineering to tag the endogenous protein.

Published
2022
Full Text
View/download PDF

2. Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

Author

Vasiliki Panagiotakopoulou, Dina Ivanyuk, Silvia De Cicco, Wadood Haq, Aleksandra Arsić, Cong Yu, Daria Messelodi, Marvin Oldrati, David C. Schöndorf, Maria-Jose Perez, Ruggiero Pio Cassatella, Meike Jakobi, Nicole Schneiderhan-Marra, Thomas Gasser, Ivana Nikić-Spiegel, and Michela Deleidi

Subjects
Science
Abstract

IFN-γ signalling is linked to regional neuronal vulnerability in Parkinson’s disease. The authors show that a PD-associated pathogenic LRRK2 missense mutation increases neuronal susceptibility to immune challenges via negative regulation of AKT phosphorylation and NFAT activation in human iPSC-derived neurons and microglia.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results