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Your search keyword '"Antonia N. Policheni"' showing total 2 results
Start Over Author "Antonia N. Policheni" Journal nature communications
2 results on '"Antonia N. Policheni"'

1. Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Author

Charis E. Teh, Najoua Lalaoui, Reema Jain, Antonia N. Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M. Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A. O’Reilly, Dale I. Godfrey, Gordon K. Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, and Daniel H. D. Gray

Subjects
Science
Abstract

LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

Published
2016
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2. Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Author

Stefanie Deuser, John Silke, Philippe Bouillet, Daniel H.D. Gray, Najoua Lalaoui, Melanie Heinlein, Andreas Strasser, Lorraine A. O'Reilly, Julie Sheridan, Henning Walczak, Silvia Alvarez-Diaz, Yifang Hu, Dale I. Godfrey, Eva Rieser, Antonia N. Policheni, Reema Jain, Maurice Darding, Charis E Teh, Hui-Fern Koay, Fiona Kupresanin, and Gordon K. Smyth

Subjects
0301 basic medicine, Genotype, Regulatory T cell, T-Lymphocytes, Ubiquitin-Protein Ligases, Cellular differentiation, Necroptosis, Science, General Physics and Astronomy, chemical and pharmacologic phenomena, Thymus Gland, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Ubiquitin, medicine, Animals, Homeostasis, Cells, Cultured, Multidisciplinary, Innate immune system, Base Sequence, biology, Sequence Analysis, RNA, Ubiquitination, Computational Biology, FOXP3, Cell Differentiation, hemic and immune systems, General Chemistry, Acquired immune system, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Immunology, biology.protein, RNA, Protein Multimerization, Protein Processing, Post-Translational, 030215 immunology
Abstract

The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3+ regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation., LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

Published
2016

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