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Start Over Author "C. Anthony Scott" Journal nature communications
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1. DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

Author

Harry MacKay, C. Anthony Scott, Jack D. Duryea, Maria S. Baker, Eleonora Laritsky, Amanda E. Elson, Theodore Garland Jr., Marta L. Fiorotto, Rui Chen, Yumei Li, Cristian Coarfa, Richard B. Simerly, and Robert A. Waterland

Subjects
Science
Abstract

AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise along with numerous epigenetic and gene expression changes in ARH neurons.

Published
2019
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