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Start Over Author "CHEN Xin" Journal nature communications
277 results on '"CHEN Xin"'

1. Femtosecond laser writing of ant-inspired reconfigurable microbot collectives

Author

Zhongguo Ren, Chen Xin, Kaiwen Liang, Heming Wang, Dawei Wang, Liqun Xu, Yanlei Hu, Jiawen Li, Jiaru Chu, and Dong Wu

Subjects
Science
Abstract

Abstract Microbot collectives can cooperate to accomplish complex tasks that are difficult for a single individual. However, various force-induced microbot collectives maintained by weak magnetic, light, and electric fields still face challenges such as unstable connections, the need for a continuous external stimuli source, and imprecise individual control. Here, we construct magnetic and light-driven ant microbot collectives capable of reconfiguring multiple assembled architectures with robustness. This methodology utilizes a flexible two-photon polymerization strategy to fabricate microbots consisting of magnetic photoresist, hydrogel, and metal nanoparticles. Under the cooperation of magnetic and light fields, the microbots can reversibly and selectively assemble (e.g., 90° assembly and 180° assembly) into various morphologies. Moreover, we demonstrate the ability of assembled microbots to cross a one-body-length gap and their adaptive capability to move through a constriction and transport microcargo. Our strategy will broaden the abilities of clustered microbots, including gap traversal, micro-object manipulation, and drug delivery.

Published
2024
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2. Focused ultrasound enables selective actuation and Newton-level force output of untethered soft robots

Author

Bo Hao, Xin Wang, Yue Dong, Mengmeng Sun, Chen Xin, Haojin Yang, Yanfei Cao, Jiaqi Zhu, Xurui Liu, Chong Zhang, Lin Su, Bing Li, and Li Zhang

Subjects
Science
Abstract

Abstract Untethered miniature soft robots have significant application potentials in biomedical and industrial fields due to their space accessibility and safe human interaction. However, the lack of selective and forceful actuation is still challenging in revolutionizing and unleashing their versatility. Here, we propose a focused ultrasound-controlled phase transition strategy for achieving millimeter-level spatially selective actuation and Newton-level force of soft robots, which harnesses ultrasound-induced heating to trigger the phase transition inside the robot, enabling powerful actuation through inflation. The millimeter-level spatial resolution empowers single robot to perform multiple tasks according to specific requirements. As a concept-of-demonstration, we designed soft robot for liquid cargo delivery and biopsy robot for tissue acquisition and patching. Additionally, an autonomous control system is integrated with ultrasound imaging to enable automatic acoustic field alignment and control. The proposed method advances the spatiotemporal response capability of untethered miniature soft robots, holding promise for broadening their versatility and adaptability.

Published
2024
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3. Light-triggered multi-joint microactuator fabricated by two-in-one femtosecond laser writing

Author

Chen Xin, Zhongguo Ren, Leran Zhang, Liang Yang, Dawei Wang, Yanlei Hu, Jiawen Li, Jiaru Chu, Li Zhang, and Dong Wu

Subjects
Science
Abstract

Abstract Inspired by the flexible joints of humans, actuators containing soft joints have been developed for various applications, including soft grippers, artificial muscles, and wearable devices. However, integrating multiple microjoints into soft robots at the micrometer scale to achieve multi-deformation modalities remains challenging. Here, we propose a two-in-one femtosecond laser writing strategy to fabricate microjoints composed of hydrogel and metal nanoparticles, and develop multi-joint microactuators with multi-deformation modalities (>10), requiring short response time (30 ms) and low actuation power (

Published
2023
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4. High-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile

Author

Hao Wu, Yiyu Chen, Wenlong Xu, Chen Xin, Tao Wu, Wei Feng, Hao Yu, Chao Chen, Shaojun Jiang, Yachao Zhang, Xiaojie Wang, Minghui Duan, Cong Zhang, Shunli Liu, Dawei Wang, Yanlei Hu, Jiawen Li, Erqiang Li, HengAn Wu, Jiaru Chu, and Dong Wu

Subjects
Science
Abstract

Utilizing the Marangoni effect, miniaturized machineries can be endowed with self-propulsion. Here, the authors report high-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile and demonstrate multiple potential functionalities.

Published
2023
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6. Efficient nonlinear beam shaping in three-dimensional lithium niobate nonlinear photonic crystals

Author

Dunzhao Wei, Chaowei Wang, Xiaoyi Xu, Huijun Wang, Yanlei Hu, Pengcheng Chen, Jiawen Li, Yunzhi Zhu, Chen Xin, Xiaopeng Hu, Yong Zhang, Dong Wu, Jiaru Chu, Shining Zhu, and Min Xiao

Subjects
Science
Abstract

Generation of light with desirable amplitude and phase profiles with nonlinear wavefront shaping is of great interest for optical technologies. Here, the authors demonstrate efficient nonlinear beam shaping using three-dimensional lithium niobate photonic crystals fabricated using a femtosecond-laser-engineering technique.

Published
2019
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7. SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis.

Author

Zhao, Wennan, Wang, Xue, Han, Lifeng, Zhang, Chunze, Wang, Chenxi, Kong, Dexin, Zhang, Mingzhe, Xu, Tong, Li, Gen, Hu, Ge, Luo, Jiahua, Yee, Sook Wah, Yang, Jia, Stahl, Andreas, Chen, Xin, and Zhang, Youcai

Subjects
Humans, beta Catenin, Animals, Liver Neoplasms, Mice, Cell Line, Tumor, Glutathione, Gene Expression Regulation, Neoplastic, TOR Serine-Threonine Kinases, Wnt Signaling Pathway, Leucine, Proto-Oncogene Proteins c-myc, Amino Acid Transport System y+, Carcinoma, Hepatocellular, Male, Large Neutral Amino Acid-Transporter 1
Abstract

Activated Wnt/β-catenin pathway is a key genetic event in liver cancer development. Solute carrier (SLC) transporters are promising drug targets. Here, we identify SLC13A3 as a drug-targetable effector downstream of β-catenin in liver cancer. SLC13A3 expression is elevated in human liver cancer samples with gain of function (GOF) mutant CTNNB1, the gene encoding β-catenin. Activation of β-catenin up-regulates SLC13A3, leading to intracellular accumulation of endogenous SLC13A3 substrates. SLC13A3 is identified as a low-affinity transporter for glutathione (GSH). Silencing of SLC13A3 downregulates the leucine transporter SLC7A5 via c-MYC signaling, leading to leucine depletion and mTOR inactivation. Furthermore, silencing of SLC13A3 depletes GSH and induces autophagic ferroptosis in β-catenin-activated liver cancer cells. Importantly, both genetic inhibition of SLC13A3 and a small molecule SLC13A3 inhibitor suppress β-catenin-driven hepatocarcinogenesis in mice. Altogether, our study suggests that SLC13A3 could be a promising therapeutic target for treating human liver cancers with GOF CTNNB1 mutations.

Published
2024

17. Ultra-high spin emission from antiferromagnetic FeRh

Author

Hamara, Dominik, Strungaru, Mara, Massey, Jamie R., Remy, Quentin, Chen, Xin, Nava Antonio, Guillermo, Alves Santos, Obed, Hehn, Michel, Evans, Richard F. L., Chantrell, Roy W., Mangin, Stéphane, Ducati, Caterina, Marrows, Christopher H., Barker, Joseph, and Ciccarelli, Chiara

Published
2024
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33. A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Author

Yao, Fan, Deng, Yalan, Zhao, Yang, Mei, Ying, Zhang, Yilei, Liu, Xiaoguang, Martinez, Consuelo, Su, Xiaohua, Rosato, Roberto R, Teng, Hongqi, Hang, Qinglei, Yap, Shannon, Chen, Dahu, Wang, Yumeng, Chen, Mei-Ju May, Zhang, Mutian, Liang, Han, Xie, Dong, Chen, Xin, Zhu, Hao, Chang, Jenny C, You, M James, Sun, Yutong, Gan, Boyi, and Ma, Li

Subjects
Rare Diseases, Biotechnology, Digestive Diseases, Liver Cancer, Liver Disease, Cancer, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Aetiology, Development of treatments and therapeutic interventions, Good Health and Well Being, Animals, Antibodies, Neutralizing, Carcinogenesis, Carcinoma, Hepatocellular, Cell Line, Tumor, Down-Regulation, Ferroptosis, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Leukemia Inhibitory Factor Receptor alpha Subunit, Lipocalin-2, Liver Neoplasms, Male, Mice, Inbred C57BL, NF-kappa B, Piperazines, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Signal Transduction, Sorafenib, Up-Regulation, Xenograft Model Antitumor Assays
Abstract

The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer, primarily hepatocellular carcinoma (HCC), is highly lethal with limited treatment options. LIFR is frequently downregulated in HCC. Here, by studying hepatocyte-specific and inducible Lifr-knockout mice, we show that loss of Lifr promotes liver tumorigenesis and confers resistance to drug-induced ferroptosis. Mechanistically, loss of LIFR activates NF-κB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers. Notably, an LCN2-neutralizing antibody enhances the ferroptosis-inducing and anticancer effects of sorafenib on HCC patient-derived xenograft tumors with low LIFR expression and high LCN2 expression. Thus, anti-LCN2 therapy is a promising way to improve liver cancer treatment by targeting ferroptosis.

Published
2021

34. Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.

Author

Liu, Yufeng, Jiang, Shengdian, Li, Yingxin, Zhao, Sujun, Yun, Zhixi, Zhao, Zuo-Han, Zhang, Lingli, Wang, Gaoyu, Chen, Xin, Manubens-Gil, Linus, Hang, Yuning, Gong, Qiaobo, Li, Yuanyuan, Qian, Penghao, Qu, Lei, Garcia-Forn, Marta, Wang, Wei, De Rubeis, Silvia, Wu, Zhuhao, and Osten, Pavel

Abstract

We conducted a large-scale whole-brain morphometry study by analyzing 3.7 peta-voxels of mouse brain images at the single-cell resolution, producing one of the largest multi-morphometry databases of mammalian brains to date. We registered 204 mouse brains of three major imaging modalities to the Allen Common Coordinate Framework (CCF) atlas, annotated 182,497 neuronal cell bodies, modeled 15,441 dendritic microenvironments, characterized the full morphology of 1876 neurons along with their axonal motifs, and detected 2.63 million axonal varicosities that indicate potential synaptic sites. Our analyzed six levels of information related to neuronal populations, dendritic microenvironments, single-cell full morphology, dendritic and axonal arborization, axonal varicosities, and sub-neuronal structural motifs, along with a quantification of the diversity and stereotypy of patterns at each level. This integrative study provides key anatomical descriptions of neurons and their types across a multiple scales and features, contributing a substantial resource for understanding neuronal diversity in mammalian brains. Here the authors analyzed 3.7 petavoxels of 3D imaging data from 204 mouse brains, aiming to comprehensively characterize diverse morphological and modular patterns conserved across six spatial scales of mouse brain anatomy, ranging from the whole-brain scale to synaptic levels. [ABSTRACT FROM AUTHOR]

Published
2024
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35. A diuranium carbide cluster stabilized inside a C80 fullerene cage.

Author

Zhang, Xingxing, Li, Wanlu, Feng, Lai, Chen, Xin, Hansen, Andreas, Grimme, Stefan, Fortier, Skye, Sergentu, Dumitru-Claudiu, Duignan, Thomas J, Autschbach, Jochen, Wang, Shuao, Wang, Yaofeng, Velkos, Giorgios, Popov, Alexey A, Aghdassi, Nabi, Duhm, Steffen, Li, Xiaohong, Li, Jun, Echegoyen, Luis, Schwarz, WH Eugen, and Chen, Ning

Abstract

Unsupported non-bridged uranium-carbon double bonds have long been sought after in actinide chemistry as fundamental synthetic targets in the study of actinide-ligand multiple bonding. Here we report that, utilizing Ih(7)-C80 fullerenes as nanocontainers, a diuranium carbide cluster, U=C=U, has been encapsulated and stabilized in the form of UCU@Ih(7)-C80. This endohedral fullerene was prepared utilizing the Krätschmer-Huffman arc discharge method, and was then co-crystallized with nickel(II) octaethylporphyrin (NiII-OEP) to produce UCU@Ih(7)-C80·[NiII-OEP] as single crystals. X-ray diffraction analysis reveals a cage-stabilized, carbide-bridged, bent UCU cluster with unexpectedly short uranium-carbon distances (2.03 Å) indicative of covalent U=C double-bond character. The quantum-chemical results suggest that both U atoms in the UCU unit have formal oxidation state of +5. The structural features of UCU@Ih(7)-C80 and the covalent nature of the U(f1)=C double bonds were further affirmed through various spectroscopic and theoretical analyses.

Published
2018

41. Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

Author

Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, and Yauch, Robert L.

Published
2022
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