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Your search keyword '"Caliebe, Amke"' showing total 6 results
Start Over Author "Caliebe, Amke" Journal nature communications
6 results on '"Caliebe, Amke"'

1. Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Author

Irizar, Peer Aramillo, Schäuble, Sascha, Esser, Daniela, Groth, Marco, Frahm, Christiane, Priebe, Steffen, Baumgart, Mario, Hartmann, Nils, Marthandan, Shiva, Menzel, Uwe, Müller, Jule, Schmidt, Silvio, Ast, Volker, Caliebe, Amke, König, Rainer, Krawczak, Michael, Ristow, Michael, Schuster, Stefan, Cellerino, Alessandro, Diekmann, Stephan, Englert, Christoph, Hemmerich, Peter, Sühnel, Jürgen, Guthke, Reinhard, Witte, Otto W., Platzer, Matthias, Ruppin, Eytan, and Kaleta, Christoph

Published
2019
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2. Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Author

Aramillo Irizar, Peer, Schäuble, Sascha, Esser, Daniela, Groth, Marco, Frahm, Christiane, Priebe, Steffen, Baumgart, Mario, Hartmann, Nils, Marthandan, Shiva, Menzel, Uwe, Müller, Jule, Schmidt, Silvio, Ast, Volker, Caliebe, Amke, König, Rainer, Krawczak, Michael, Ristow, Michael, Schuster, Stefan, Cellerino, Alessandro, Diekmann, Stephan, Englert, Christoph, Hemmerich, Peter, Sühnel, Jürgen, Guthke, Reinhard, Witte, Otto W., Platzer, Matthias, Ruppin, Eytan, and Kaleta, Christoph

Published
2018
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3. Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Author

Krause-Kyora, Ben, primary, Nutsua, Marcel, additional, Boehme, Lisa, additional, Pierini, Federica, additional, Pedersen, Dorthe Dangvard, additional, Kornell, Sabin-Christin, additional, Drichel, Dmitriy, additional, Bonazzi, Marion, additional, Möbus, Lena, additional, Tarp, Peter, additional, Susat, Julian, additional, Bosse, Esther, additional, Willburger, Beatrix, additional, Schmidt, Alexander H., additional, Sauter, Jürgen, additional, Franke, Andre, additional, Wittig, Michael, additional, Caliebe, Amke, additional, Nothnagel, Michael, additional, Schreiber, Stefan, additional, Boldsen, Jesper L., additional, Lenz, Tobias L., additional, and Nebel, Almut, additional

Published
2018
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4. Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3

Author

Flachsbart, Friederike, primary, Dose, Janina, additional, Gentschew, Liljana, additional, Geismann, Claudia, additional, Caliebe, Amke, additional, Knecht, Carolin, additional, Nygaard, Marianne, additional, Badarinarayan, Nandini, additional, ElSharawy, Abdou, additional, May, Sandra, additional, Luzius, Anne, additional, Torres, Guillermo G., additional, Jentzsch, Marlene, additional, Forster, Michael, additional, Häsler, Robert, additional, Pallauf, Kathrin, additional, Lieb, Wolfgang, additional, Derbois, Céline, additional, Galan, Pilar, additional, Drichel, Dmitriy, additional, Arlt, Alexander, additional, Till, Andreas, additional, Krause-Kyora, Ben, additional, Rimbach, Gerald, additional, Blanché, Hélène, additional, Deleuze, Jean-François, additional, Christiansen, Lene, additional, Christensen, Kaare, additional, Nothnagel, Michael, additional, Rosenstiel, Philip, additional, Schreiber, Stefan, additional, Franke, Andre, additional, Sebens, Susanne, additional, and Nebel, Almut, additional

Published
2018
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5. Identification and characterization of two functional variants in the human longevity gene FOXO3

Author

Flachsbart, Friederike, primary, Dose, Janina, additional, Gentschew, Liljana, additional, Geismann, Claudia, additional, Caliebe, Amke, additional, Knecht, Carolin, additional, Nygaard, Marianne, additional, Badarinarayan, Nandini, additional, ElSharawy, Abdou, additional, May, Sandra, additional, Luzius, Anne, additional, Torres, Guillermo G., additional, Jentzsch, Marlene, additional, Forster, Michael, additional, Häsler, Robert, additional, Pallauf, Kathrin, additional, Lieb, Wolfgang, additional, Derbois, Céline, additional, Galan, Pilar, additional, Drichel, Dmitriy, additional, Arlt, Alexander, additional, Till, Andreas, additional, Krause-Kyora, Ben, additional, Rimbach, Gerald, additional, Blanché, Hélène, additional, Deleuze, Jean-François, additional, Christiansen, Lene, additional, Christensen, Kaare, additional, Nothnagel, Michael, additional, Rosenstiel, Philip, additional, Schreiber, Stefan, additional, Franke, Andre, additional, Sebens, Susanne, additional, and Nebel, Almut, additional

Published
2017
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6. Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Author

Julia J. Müller, Michael Ristow, Eytan Ruppin, Amke Caliebe, Steffen Priebe, Stefan Schuster, Shiva Marthandan, Alessandro Cellerino, Matthias Platzer, Peer Aramillo Irizar, Silvio Schmidt, Christoph Englert, Nils Hartmann, Rainer König, Jürgen Sühnel, Stephan Diekmann, Sascha Schäuble, Uwe Menzel, Michael Krawczak, Otto W. Witte, Peter Hemmerich, Marco Groth, Volker Ast, Reinhard Guthke, Christiane Frahm, Christoph Kaleta, Daniela Esser, Mario Baumgart, Aramillo Irizar, Peer, Schäuble, Sascha, Esser, Daniela, Groth, Marco, Frahm, Christiane, Priebe, Steffen, Baumgart, Mario, Hartmann, Nil, Marthandan, Shiva, Menzel, Uwe, Müller, Julia, Schmidt, Silvio, Ast, Volker, Caliebe, Amke, König, Rainer, Krawczak, Michael, Ristow, Michael, Schuster, Stefan, Cellerino, Alessandro, Diekmann, Stephan, Englert, Christoph, Hemmerich, Peter, Sühnel, Jürgen, Guthke, Reinhard, Witte, Otto W, Platzer, Matthia, Ruppin, Eytan, and Kaleta, Christoph

Subjects
0301 basic medicine, Aging, General Physics and Astronomy, Bioinformatics, Settore BIO/09 - Fisiologia, Transcriptome, Mice, Diabetes mellitus genetics, Fundulidae, Neoplasms, Epidemiology, Child, Zebrafish, Skin, Cancer, Aged, 80 and over, Multidisciplinary, Brain, Neurodegenerative Diseases, Middle Aged, Publisher Correction, Liver, Cardiovascular Diseases, Child, Preschool, Adult, medicine.medical_specialty, Adolescent, Degenerative Disorder, Science, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Computational biology and bioinformatics, Genetic association study, Ageing, Diabetes Mellitus, medicine, Animals, Humans, Aged, Genome, Human, Infant, Molecular Sequence Annotation, General Chemistry, medicine.disease, Chronic disorders, Gene Ontology, 030104 developmental biology, Chronic Disease, Risk allele
Abstract

Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories similar to the transcriptional alterations observed in degenerative ageing diseases but are in opposite direction to the transcriptomic alterations observed in cancer. We confirm the existence of a similar antagonism on the genomic level, where a majority of shared risk alleles which increase the risk of cancer decrease the risk of chronic degenerative disorders and vice versa. These results reveal a fundamental trade-off between cancer and degenerative ageing diseases that sheds light on the pronounced shift in their epidemiology during ageing., Nature Communications, 9, ISSN:2041-1723

Published
2018

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