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Start Over Author "Caroline Lew" Journal nature communications
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1. m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Author

G. Guy Bushkin, David Pincus, Jeffrey T. Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P. Bartel, and Gerald R. Fink

Subjects
Science
Abstract

Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.

Published
2019
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