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Start Over Author "Cui, Wei" Journal nature communications
17 results on '"Cui, Wei"'

2. Author Correction: MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.

Author

Lv, Cong, Li, Fengyin, Li, Xiang, Tian, Yuhua, Zhang, Yue, Sheng, Xiaole, Song, Yongli, Meng, Qingyong, Yuan, Shukai, Luan, Liming, Andl, Thomas, Feng, Xu, Jiao, Baowei, Xu, Mingang, Plikus, Maksim V, Dai, Xing, Lengner, Christopher, Cui, Wei, Ren, Fazheng, Shuai, Jianwei, Millar, Sarah E, and Yu, Zhengquan

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

5. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.

Author

Lv, Cong, Li, Fengyin, Li, Xiang, Tian, Yuhua, Zhang, Yue, Sheng, Xiaole, Song, Yongli, Meng, Qingyong, Yuan, Shukai, Luan, Liming, Andl, Thomas, Feng, Xu, Jiao, Baowei, Xu, Mingang, Plikus, Maksim V, Dai, Xing, Lengner, Christopher, Cui, Wei, Ren, Fazheng, Shuai, Jianwei, Millar, Sarah E, and Yu, Zhengquan

Subjects
Mammary Glands, Human, Cell Line, Tumor, Stem Cells, Animals, Mice, Inbred C57BL, Mice, Transgenic, Humans, Mice, Breast Neoplasms, NF-kappa B, MicroRNAs, Cell Proliferation, Down-Regulation, Gene Expression Regulation, Neoplastic, Female, Wnt Proteins, beta Catenin, Neoplastic Stem Cells, Wnt Signaling Pathway, Cell Self Renewal, Stem Cell Research - Nonembryonic - Human, Breast Cancer, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Biotechnology, Genetics, 2.1 Biological and endogenous factors, Mammary Glands, Human, Cell Line, Tumor, Inbred C57BL, Transgenic, Gene Expression Regulation, Neoplastic
Abstract

MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly understood. Here we show that miR-31 is highly expressed in MaSC-enriched mammary basal cell population and in mammary tumors, and is regulated by NF-κB signaling. We demonstrate that miR-31 promotes mammary epithelial proliferation and MaSC expansion at the expense of differentiation in vivo. Loss of miR-31 compromises mammary tumor growth, reduces the number of cancer stem cells, as well as decreases tumor-initiating ability and metastasis to the lung, supporting its pro-oncogenic function. MiR-31 modulates multiple signaling pathways, including Prlr/Stat5, TGFβ and Wnt/β-catenin. Particularly, it activates Wnt/β-catenin signaling by directly targeting Wnt antagonists, including Dkk1. Importantly, Dkk1 overexpression partially rescues miR31-induced mammary defects. Together, these findings identify miR-31 as the key regulator of MaSC activity and breast tumorigenesis.

Published
2017

6. Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis

Author

Liu, Yongmei, Reynolds, Lindsay M, Ding, Jingzhong, Hou, Li, Lohman, Kurt, Young, Tracey, Cui, Wei, Huang, Zhiqing, Grenier, Carole, Wan, Ma, Stunnenberg, Hendrik G, Siscovick, David, Hou, Lifang, Psaty, Bruce M, Rich, Stephen S, Rotter, Jerome I, Kaufman, Joel D, Burke, Gregory L, Murphy, Susan, Jacobs, David R, Post, Wendy, Hoeschele, Ina, Bell, Douglas A, Herrington, David, Parks, John S, Tracy, Russell P, McCall, Charles E, and Stein, James H

Subjects
Biological Sciences, Genetics, Human Genome, Atherosclerosis, Clinical Research, Cardiovascular, Aging, Aetiology, 2.1 Biological and endogenous factors, Aged, DNA Methylation, DNA-Binding Proteins, Epigenesis, Genetic, Female, Histones, Humans, Male, Middle Aged, Monocytes, Transcription Factors, Transcriptome
Abstract

Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes transcription coactivator, ARID5B, which is known to form a chromatin derepressor complex with a histone H3K9Me2-specific demethylase and promote adipogenesis and smooth muscle development. ARID5B CpG (cg25953130) methylation is inversely associated with both ARID5B expression and atherosclerosis, consistent with this CpG residing in an ARID5B enhancer region, based on chromatin capture and histone marks data. Mediation analysis supports assumptions that ARID5B expression mediates effects of cg25953130 methylation and several cardiovascular disease risk factors on atherosclerotic burden. In lipopolysaccharide-stimulated human THP1 monocytes, ARID5B knockdown reduced expression of genes involved in atherosclerosis-related inflammatory and lipid metabolism pathways, and inhibited cell migration and phagocytosis. These data suggest that ARID5B expression, possibly regulated by an epigenetically controlled enhancer, promotes atherosclerosis by dysregulating immunometabolism towards a chronic inflammatory phenotype.The molecular mechanisms mediating the impact of environmental factors in atherosclerosis are unclear. Here, the authors examine CD14+ blood monocyte's transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.

Published
2017

11. Insight-HXMT observations of jet-like corona in a black hole X-ray binary MAXI J1820+070

Author

You, Bei, Tuo, Yuoli, Li, Chengzhe, Wang, Wei, Zhang, Shuang-Nan, Zhang, Shu, Ge, Mingyu, Luo, Chong, Liu, Bifang, Yuan, Weimin, Dai, Zigao, Liu, Jifeng, Qiao, Erlin, Jin, Chichuan, Liu, Zhu, Czerny, Bozena, Wu, Qingwen, Bu, Qingcui, Cai, Ce, Cao, Xuelei, Chang, Zhi, Chen, Gang, Chen, Li, Chen, Tianxiang, Chen, Yibao, Chen, Yong, Chen, Yupeng, Cui, Wei, Cui, Weiwei, Deng, Jingkang, Dong, Yongwei, Du, Yuanyuan, Fu, Minxue, Gao, Guanhua, Gao, He, Gao, Min, Gu, Yudong, Guan, Ju, Guo, Chengcheng, Han, Dawei, Huang, Yue, Huo, Jia, Jia, Shumei, Jiang, Luhua, Jiang, Weichun, Jin, Jing, Jin, Yongjie, Kong, Lingda, Li, Bing, Li, Chengkui, Li, Gang, Li, Maoshun, Li, Tipei, Li, Wei, Li, Xian, Li, Xiaobo, Li, Xufang, Li, Yanguo, Li, Zhengwei, Liang, Xiaohua, Liao, Jinyuan, Liu, Congzhan, Liu, Guoqing, Liu, Hongwei, Liu, Xiaojing, Liu, Yinong, Lu, Bo, Lu, Fangjun, Lu, Xuefeng, Luo, Qi, Luo, Tao, Ma, Xiang, Meng, Bin, Nang, Yi, Nie, Jianyin, Ou, Ge, Qu, Jinlu, Sai, Na, Shang, Rencheng, Song, Liming, Song, Xinying, Sun, Liang, Tan, Ying, Tao, Lian, Wang, Chen, Wang, Guofeng, Wang, Juan, Wang, Lingjun, Wang, Wenshuai, Wang, Yusa, Wen, Xiangyang, Wu, Baiyang, Wu, Bobing, Wu, Mei, Xiao, Guangcheng, Xiao, Shuo, Xiong, Shaolin, Xu, Yupeng, Yang, Jiawei, Yang, Sheng, Yang, Yanji, Yi, Qibin, Yin, Qianqing, You, Yuan, Zhang, Aimei, Zhang, Chengmo, Zhang, Fan, Zhang, Hongmei, Zhang, Juan, Zhang, Tong, Zhang, Wanchang, Zhang, Wei, Zhang, Wenzhao, Zhang, Yi, Zhang, Yifei, Zhang, Yongjie, Zhang, Yue, Zhang, Zhao, Zhang, Ziliang, Zhao, Haisheng, Zhao, Xiaofan, Zheng, Shijie, Zhou, Dengke, Zhou, Jianfeng, Zhu, Yuxuan, and Zhu, Yue

Published
2021
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13. An ionic vinylene-linked three-dimensional covalent organic framework for selective and efficient trapping of ReO4− or 99TcO4−.

Author

Zhang, Cheng-Rong, Cui, Wei-Rong, Yi, Shun-Mo, Niu, Cheng-Peng, Liang, Ru-Ping, Qi, Jia-Xin, Chen, Xiao-Juan, Jiang, Wei, Liu, Xin, Luo, Qiu-Xia, and Qiu, Jian-Ding

Subjects
CARBON-carbon bonds, CHEMICAL stability, DOUBLE bonds, ALDOL condensation, ALKENES, TRIAZINES
Abstract

The synthesis of ionic olefin linked three-dimensional covalent organic frameworks (3D COFs) is greatly challenging given the hardness of the formation of stable carbon-carbon double bonds (–C = C–). Herein, we report a general strategy for designing porous positively charged sp2 carbon-linked 3D COFs through the Aldol condensation promoted by quaternization. The obtained 3D COFs, namely TFPM-PZI and TAPM-PZI, showed impressive chemical stability. Furthermore, the positively charged frameworks with regular porosity endow 3D ionic COFs with selective capture radioactive ReO4−/TcO4− and great removal efficiency in simulated Hanford waste. This research not only broadens the category of 3D COFs but also promotes the application of COFs as efficient functional materials. The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp2 carbon linked COFs and demonstrate selective capture of ReO4− ions. [ABSTRACT FROM AUTHOR]

Published
2022
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