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Start Over Author "Delphine Guillemot" Journal nature communications
3 results on '"Delphine Guillemot"'

1. Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups

Author

María-Jesús Lobón-Iglesias, Mamy Andrianteranagna, Zhi-Yan Han, Céline Chauvin, Julien Masliah-Planchon, Valeria Manriquez, Arnault Tauziede-Espariat, Sandrina Turczynski, Rachida Bouarich-Bourimi, Magali Frah, Christelle Dufour, Thomas Blauwblomme, Liesbeth Cardoen, Gaelle Pierron, Laetitia Maillot, Delphine Guillemot, Stéphanie Reynaud, Christine Bourneix, Célio Pouponnot, Didier Surdez, Mylene Bohec, Sylvain Baulande, Olivier Delattre, Eliane Piaggio, Olivier Ayrault, Joshua J. Waterfall, Nicolas Servant, Kevin Beccaria, Volodia Dangouloff-Ros, and Franck Bourdeaut

Subjects
Science
Abstract

Abstract Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from the basal ganglia (BG) and intra-ventricular (IV) regions. Molecular characteristics point to the midbrain-hindbrain boundary as the origin of CAL SHH ATRT, and to the ganglionic eminence as the origin of BG/IV SHH ATRT. Single-cell RNA sequencing on SHH ATRT supports these hypotheses. Trajectory analyses suggest that SMARCB1 loss induces a de-differentiation process mediated by repressors of the neuronal program such as REST, ID and the NOTCH pathway.

Published
2023
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2. The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

Author

Zhi-Yan Han, Wilfrid Richer, Paul Fréneaux, Céline Chauvin, Carlo Lucchesi, Delphine Guillemot, Camille Grison, Delphine Lequin, Gaelle Pierron, Julien Masliah-Planchon, André Nicolas, Dominique Ranchère-Vince, Pascale Varlet, Stéphanie Puget, Isabelle Janoueix-Lerosey, Olivier Ayrault, Didier Surdez, Olivier Delattre, and Franck Bourdeaut

Subjects
Science
Abstract

SMARCB1 inactivation is prevalent in human atypical teratoid/rhabdoid tumours but a mouse model that accurately phenocopies the human disease is lacking. Here, the authors show that inactivation of SMARCB1between E6 and E10 in mice results in tumours that better recapitulate the human phenotype, compared to previously reported models.

Published
2016
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3. The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

Author

André Nicolas, Wilfrid Richer, Camille Grison, Paul Fréneaux, Olivier Delattre, Céline Chauvin, Olivier Ayrault, Gaëlle Pierron, Dominique Ranchère-Vince, Delphine Guillemot, Delphine Lequin, Franck Bourdeaut, Stéphanie Puget, Julien Masliah-Planchon, Pascale Varlet, Carlo Lucchesi, Didier Surdez, Isabelle Janoueix-Lerosey, and Zhi-Yan Han

Subjects
Male, 0301 basic medicine, Chromosomal Proteins, Non-Histone, Science, Central nervous system, General Physics and Astronomy, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, Gene expression, medicine, Animals, Humans, Gene silencing, Gene Silencing, SMARCB1, Rhabdoid Tumor, Regulation of gene expression, Multidisciplinary, Brain Neoplasms, SMARCB1 Protein, General Chemistry, Embryonic stem cell, Phenotype, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Tamoxifen, 030104 developmental biology, medicine.anatomical_structure, Child, Preschool, Cancer research, Female, Transcription Factors, medicine.drug
Abstract

Rhabdoid tumours (RTs) are highly aggressive tumours of infancy, frequently localized in the central nervous system (CNS) where they are termed atypical teratoid/rhabdoid tumours (AT/RTs) and characterized by bi-allelic inactivation of the SMARCB1 tumour suppressor gene. In this study, by temporal control of tamoxifen injection in Smarcb1flox/flox;Rosa26-CreERT2 mice, we explore the phenotypes associated with Smarcb1 inactivation at different developmental stages. Injection before E6, at birth or at 2 months of age recapitulates previously described phenotypes including embryonic lethality, hepatic toxicity or development of T-cell lymphomas, respectively. Injection between E6 and E10 leads to high penetrance tumours, mainly intra-cranial, with short delays (median: 3 months). These tumours demonstrate anatomical, morphological and gene expression profiles consistent with those of human AT/RTs. Moreover, intra- and inter-species comparisons of tumours reveal that human and mouse RTs can be split into different entities that may underline the variety of RT cells of origin., SMARCB1 inactivation is prevalent in human atypical teratoid/rhabdoid tumours but a mouse model that accurately phenocopies the human disease is lacking. Here, the authors show that inactivation of SMARCB1 between E6 and E10 in mice results in tumours that better recapitulate the human phenotype, compared to previously reported models.

Published
2016

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