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Start Over Author "Elizabeth L Tyson" Journal nature communications
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1. Aromatic thiol-mediated cleavage of Nā€“O bonds enables chemical ubiquitylation of folded proteins

Author

Caroline E. Weller, Abhinav Dhall, Feizhi Ding, Edlaine Linares, Samuel D. Whedon, Nicholas A. Senger, Elizabeth L. Tyson, John D. Bagert, Xiaosong Li, Ohara Augusto, and Champak Chatterjee

Subjects
Science
Abstract

Chemical approaches to site-specifically ubiquitylate a target protein allow investigation of the biochemical effects of this modification, but they often destabilize the protein. Here, the authors report on a synthetic conjugation strategy that leads to protein ubiquitylation in non-denaturing conditions.

Published
2016
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