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Start Over Author "Erin A. McClure" Journal nature communications
4 results on '"Erin A. McClure"'

1. Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Author

Adela S. Oliva Chávez, Xiaowei Wang, Liron Marnin, Nathan K. Archer, Holly L. Hammond, Erin E. McClure Carroll, Dana K. Shaw, Brenden G. Tully, Amanda D. Buskirk, Shelby L. Ford, L. Rainer Butler, Preeti Shahi, Kateryna Morozova, Cristina C. Clement, Lauren Lawres, Anya J. O’ Neal, Choukri Ben Mamoun, Kathleen L. Mason, Brandi E. Hobbs, Glen A. Scoles, Eileen M. Barry, Daniel E. Sonenshine, Utpal Pal, Jesus G. Valenzuela, Marcelo B. Sztein, Marcela F. Pasetti, Michael L. Levin, Michail Kotsyfakis, Steven M. Jay, Jason F. Huntley, Lloyd S. Miller, Laura Santambrogio, and Joao H. F. Pedra

Subjects
Science
Abstract

Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.

Published
2021
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2. Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Author

Oliva Chávez, Adela S., Wang, Xiaowei, Marnin, Liron, Archer, Nathan K., Hammond, Holly L., Carroll, Erin E. McClure, Shaw, Dana K., Tully, Brenden G., Buskirk, Amanda D., Ford, Shelby L., Butler, L. Rainer, Shahi, Preeti, Morozova, Kateryna, Clement, Cristina C., Lawres, Lauren, Neal, Anya J. O’, Mamoun, Choukri Ben, Mason, Kathleen L., Hobbs, Brandi E., Scoles, Glen A., Barry, Eileen M., Sonenshine, Daniel E., Pal, Utpal, Valenzuela, Jesus G., Sztein, Marcelo B., Pasetti, Marcela F., Levin, Michael L., Kotsyfakis, Michail, Jay, Steven M., Huntley, Jason F., Miller, Lloyd S., Santambrogio, Laura, and Pedra, Joao H. F.

Published
2021
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3. Infection-derived lipids elicit an immune deficiency circuit in arthropods

Author

Dana K. Shaw, Xiaowei Wang, Lindsey J. Brown, Adela S. Oliva Chávez, Kathryn E. Reif, Alexis A. Smith, Alison J. Scott, Erin E. McClure, Vishant M. Boradia, Holly L. Hammond, Eric J. Sundberg, Greg A. Snyder, Lei Liu, Kathleen DePonte, Margarita Villar, Massaro W. Ueti, José de la Fuente, Robert K. Ernst, Utpal Pal, Erol Fikrig, and Joao H. F. Pedra

Subjects
Science
Abstract

The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.

Published
2017
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4. Infection-derived lipids elicit an immune deficiency circuit in arthropods

Author

Alison J. Scott, Alexis A. Smith, Lei Liu, Holly L. Hammond, Massaro W. Ueti, Eric J. Sundberg, Robert K. Ernst, Joao H. F. Pedra, Greg A. Snyder, Dana K. Shaw, Margarita Villar, Vishant Mahendra Boradia, Xiaowei Wang, Kathryn E. Reif, Adela S. Oliva Chávez, Erin E. McClure, José de la Fuente, Utpal Pal, Erol Fikrig, Kathleen DePonte, Lindsey J. Brown, National Institute of Allergy and Infectious Diseases (US), University of Maryland, and National Institutes of Health (US)

Subjects
0301 basic medicine, Fas-Associated Death Domain Protein, General Physics and Astronomy, Drosophila Proteins, FADD, RNA, Small Interfering, Lyme Disease, Multidisciplinary, biology, Pattern recognition receptor, Signal transducing adaptor protein, Phosphatidylglycerols, Lipids, Transmembrane protein, Recombinant Proteins, 3. Good health, Ubiquitin ligase, Cell biology, Anaplasma marginale, Drosophila melanogaster, lipids (amino acids, peptides, and proteins), Anaplasma phagocytophilum, Signal Transduction, Ubiquitin-Protein Ligases, Science, 030106 microbiology, X-Linked Inhibitor of Apoptosis Protein, Inhibitor of apoptosis, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, parasitic diseases, Escherichia coli, Animals, Humans, Gene Silencing, Borrelia burgdorferi, Arthropods, Diacylglycerol kinase, Adaptor Proteins, Signal Transducing, Ixodes, Immunologic Deficiency Syndromes, General Chemistry, biology.organism_classification, bacterial infections and mycoses, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, Ubiquitin-Conjugating Enzymes, biology.protein, Carrier Proteins, Transcription Factors
Abstract

The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. The tick IMD network protects against colonization by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale. Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death domain (FADD) and IMD. Conversely, biochemical interactions occur between x-linked inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless. We propose the existence of two functionally distinct IMD networks, one in insects and another in ticks., This work was supported by the National Institutes of Health (R01 AI093653 and R01AI116523 to J.H.F.P.) and the University of Maryland, Baltimore School of Medicine. E.E.M. was a trainee under the Institutional Training Grant T32AI007540 from the National Institute of Allergy and Infectious Diseases.

Published
2017

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