Search

Your search keyword '"Eszter Nemeth"' showing total 1 results
Start Over Author "Eszter Nemeth" Journal nature communications
1 results on '"Eszter Nemeth"'

1. BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1

Author

Dan Chen, Judit Z. Gervai, Ádám Póti, Eszter Németh, Zoltán Szeltner, Bernadett Szikriszt, Zsolt Gyüre, Judit Zámborszky, Marta Ceccon, Fabrizio d’Adda di Fagagna, Zoltan Szallasi, Andrea L. Richardson, and Dávid Szüts

Subjects
Science
Abstract

Loss of BRCA1 or BRCA2 results in genomic instability; however most studies have focused on the role of these proteins in double-strand break repair. Here the authors coupled cell line genetics and whole genome sequencing to investigate the formation of base substitutions and short indels in BRCA1-deficient cells, revealing a role for translesion DNA synthesis regulated by 53BP1.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results