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Your search keyword '"Fulton, Robert A."' showing total 11 results
Start Over Author "Fulton, Robert A." Journal nature communications
11 results on '"Fulton, Robert A."'

2. Co-evolution of tumor and immune cells during progression of multiple myeloma

Author

Liu, Ruiyang, Gao, Qingsong, Foltz, Steven M., Fowles, Jared S., Yao, Lijun, Wang, Julia Tianjiao, Cao, Song, Sun, Hua, Wendl, Michael C., Sethuraman, Sunantha, Weerasinghe, Amila, Rettig, Michael P., Storrs, Erik P., Yoon, Christopher J., Wyczalkowski, Matthew A., McMichael, Joshua F., Kohnen, Daniel R., King, Justin, Goldsmith, Scott R., O’Neal, Julie, Fulton, Robert S., Fronick, Catrina C., Ley, Timothy J., Jayasinghe, Reyka G., Fiala, Mark A., Oh, Stephen T., DiPersio, John F., Vij, Ravi, and Ding, Li

Published
2021
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3. Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children.

Author

Xu, Heng, Zhang, Hui, Yang, Wenjian, Yadav, Rachita, Morrison, Alanna C, Qian, Maoxiang, Devidas, Meenakshi, Liu, Yu, Perez-Andreu, Virginia, Zhao, Xujie, Gastier-Foster, Julie M, Lupo, Philip J, Neale, Geoff, Raetz, Elizabeth, Larsen, Eric, Bowman, W Paul, Carroll, William L, Winick, Naomi, Williams, Richard, Hansen, Torben, Holm, Jens-Christian, Mardis, Elaine, Fulton, Robert, Pui, Ching-Hon, Zhang, Jinghui, Mullighan, Charles G, Evans, William E, Hunger, Stephen P, Gupta, Ramneek, Schmiegelow, Kjeld, Loh, Mignon L, Relling, Mary V, and Yang, Jun J

Subjects
Hematopoietic Stem Cells, Animals, Humans, Mice, Genetic Predisposition to Disease, DNA-Binding Proteins, Transcription Factors, Case-Control Studies, Mutagenesis, Site-Directed, Genotype, Germ-Line Mutation, Mutation, Missense, Child, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15, Ikaros Transcription Factor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Genetic Variation, Genome-Wide Association Study, HEK293 Cells, Mutagenesis, Site-Directed, Mutation, Missense
Abstract

There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associated with the development of ALL at genome-wide significance (rs3731249, P=9.4 × 10(-23), odds ratio=2.23). Functional studies indicate that this hypomorphic variant results in reduced tumour suppressor function of p16(INK4A), increases the susceptibility to leukaemic transformation of haematopoietic progenitor cells, and is preferentially retained in ALL tumour cells. Resequencing the CDKN2A-CDKN2B locus in 2,407 childhood ALL cases reveals 19 additional putative functional germline variants. These results provide direct functional evidence for the influence of inherited genetic variation on ALL risk, highlighting the important and complex roles of CDKN2A-CDKN2B tumour suppressors in leukaemogenesis.

Published
2015

5. The prognostic effects of somatic mutations in ER-positive breast cancer

Author

Griffith, Obi L., Spies, Nicholas C., Anurag, Meenakshi, Griffith, Malachi, Luo, Jingqin, Tu, Dongsheng, Yeo, Belinda, Kunisaki, Jason, Miller, Christopher A, Krysiak, Kilannin, Hundal, Jasreet, Ainscough, Benjamin J, Skidmore, Zachary L., Campbell, Katie, Kumar, Runjun, Fronick, Catrina, Cook, Lisa, Snider, Jacqueline E., Davies, Sherri, Kavuri, Shyam M., Chang, Eric C., Magrini, Vincent, Larson, David E., Fulton, Robert S, Liu, Shuzhen, Leung, Samuel, Voduc, David, Bose, Ron, Dowsett, Mitch, Wilson, Richard K., Nielsen, Torsten O., Mardis, Elaine R, and Ellis, Matthew J.

Published
2018
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6. Author Correction: The prognostic effects of somatic mutations in ER-positive breast cancer

Author

Griffith, Obi L., Spies, Nicholas C., Anurag, Meenakshi, Griffith, Malachi, Luo, Jingqin, Tu, Dongsheng, Yeo, Belinda, Kunisaki, Jason, Miller, Christopher A, Krysiak, Kilannin, Hundal, Jasreet, Ainscough, Benjamin J, Skidmore, Zachary L., Campbell, Katie, Kumar, Runjun, Fronick, Catrina, Cook, Lisa, Snider, Jacqueline E., Davies, Sherri, Kavuri, Shyam M., Chang, Eric C., Magrini, Vincent, Larson, David E., Fulton, Robert S, Liu, Shuzhen, Leung, Samuel, Voduc, David, Bose, Ron, Dowsett, Mitch, Wilson, Richard K., Nielsen, Torsten O., Mardis, Elaine R, and Ellis, Matthew J.

Published
2018
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7. Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

Author

Wagner, Alex H., Devarakonda, Siddhartha, Skidmore, Zachary L., Krysiak, Kilannin, Ramu, Avinash, Trani, Lee, Kunisaki, Jason, Masood, Ashiq, Waqar, Saiama N., Spies, Nicholas C., Morgensztern, Daniel, Waligorski, Jason, Ponce, Jennifer, Fulton, Robert S., Maggi, Jr., Leonard B., Weber, Jason D., Watson, Mark A., O’Conor, Christopher J., Ritter, Jon H., Olsen, Rachelle R., Cheng, Haixia, Mukhopadhyay, Anandaroop, Can, Ismail, Cessna, Melissa H., Oliver, Trudy G., Mardis, Elaine R., Wilson, Richard K., Griffith, Malachi, Griffith, Obi L., and Govindan, Ramaswamy

Published
2018
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8. Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Author

Wong, Terrence N., primary, Miller, Christopher A., additional, Jotte, Matthew R. M., additional, Bagegni, Nusayba, additional, Baty, Jack D., additional, Schmidt, Amy P., additional, Cashen, Amanda F., additional, Duncavage, Eric J., additional, Helton, Nichole M., additional, Fiala, Mark, additional, Fulton, Robert S., additional, Heath, Sharon E., additional, Janke, Megan, additional, Luber, Kierstin, additional, Westervelt, Peter, additional, Vij, Ravi, additional, DiPersio, John F., additional, Welch, John S., additional, Graubert, Timothy A., additional, Walter, Matthew J., additional, Ley, Timothy J., additional, and Link, Daniel C., additional

Published
2018
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9. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Author

Shirai, Cara Lunn, primary, White, Brian S., additional, Tripathi, Manorama, additional, Tapia, Roberto, additional, Ley, James N., additional, Ndonwi, Matthew, additional, Kim, Sanghyun, additional, Shao, Jin, additional, Carver, Alexa, additional, Saez, Borja, additional, Fulton, Robert S., additional, Fronick, Catrina, additional, O’Laughlin, Michelle, additional, Lagisetti, Chandraiah, additional, Webb, Thomas R., additional, Graubert, Timothy A., additional, and Walter, Matthew J., additional

Published
2017
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10. Patterns and functional implications of rare germline variants across 12 cancer types

Author

Lu, Charles, primary, Xie, Mingchao, additional, Wendl, Michael C., additional, Wang, Jiayin, additional, McLellan, Michael D., additional, Leiserson, Mark D. M., additional, Huang, Kuan-lin, additional, Wyczalkowski, Matthew A., additional, Jayasinghe, Reyka, additional, Banerjee, Tapahsama, additional, Ning, Jie, additional, Tripathi, Piyush, additional, Zhang, Qunyuan, additional, Niu, Beifang, additional, Ye, Kai, additional, Schmidt, Heather K., additional, Fulton, Robert S., additional, McMichael, Joshua F., additional, Batra, Prag, additional, Kandoth, Cyriac, additional, Bharadwaj, Maheetha, additional, Koboldt, Daniel C., additional, Miller, Christopher A., additional, Kanchi, Krishna L., additional, Eldred, James M., additional, Larson, David E., additional, Welch, John S., additional, You, Ming, additional, Ozenberger, Bradley A., additional, Govindan, Ramaswamy, additional, Walter, Matthew J., additional, Ellis, Matthew J., additional, Mardis, Elaine R., additional, Graubert, Timothy A., additional, Dipersio, John F., additional, Ley, Timothy J., additional, Wilson, Richard K., additional, Goodfellow, Paul J., additional, Raphael, Benjamin J., additional, Chen, Feng, additional, Johnson, Kimberly J., additional, Parvin, Jeffrey D., additional, and Ding, Li, additional

Published
2015
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11. Integrated analysis of germline and somatic variants in ovarian cancer

Author

Kanchi, Krishna L., primary, Johnson, Kimberly J., additional, Lu, Charles, additional, McLellan, Michael D., additional, Leiserson, Mark D. M., additional, Wendl, Michael C., additional, Zhang, Qunyuan, additional, Koboldt, Daniel C., additional, Xie, Mingchao, additional, Kandoth, Cyriac, additional, McMichael, Joshua F., additional, Wyczalkowski, Matthew A., additional, Larson, David E., additional, Schmidt, Heather K., additional, Miller, Christopher A., additional, Fulton, Robert S., additional, Spellman, Paul T., additional, Mardis, Elaine R., additional, Druley, Todd E., additional, Graubert, Timothy A., additional, Goodfellow, Paul J., additional, Raphael, Benjamin J., additional, Wilson, Richard K., additional, and Ding, Li, additional

Published
2014
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