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Start Over Author "Goldsmith, Juliet" Journal nature communications
3 results on '"Goldsmith, Juliet"'

1. Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Author

Zheng, Yiyan, Sethi, Ritika, Mangala, Lingegowda S., Taylor, Charlotte, Goldsmith, Juliet, Wang, Ming, Masuda, Kenta, Carrami, Eli M., Mannion, David, Miranda, Fabrizio, Herrero-Gonzalez, Sandra, Hellner, Karin, Chen, Fiona, Alsaadi, Abdulkhaliq, Albukhari, Ashwag, Fotso, Donatien Chedom, Yau, Christopher, Jiang, Dahai, Pradeep, Sunila, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Knapp, Stefan, Gray, Nathanael S., Campo, Leticia, Myers, Kevin A., Dhar, Sunanda, Ferguson, David, Bast, Jr, Robert C., Sood, Anil K., von Delft, Frank, and Ahmed, Ahmed Ashour

Published
2022
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2. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Author

Zheng, Yiyan, Sethi, Ritika, Mangala, Lingegowda S., Taylor, Charlotte, Goldsmith, Juliet, Wang, Ming, Masuda, Kenta, Carrami, Eli M., Mannion, David, Miranda, Fabrizio, Herrero-Gonzalez, Sandra, Hellner, Karin, Chen, Fiona, Alsaadi, Abdulkhaliq, Albukhari, Ashwag, Fotso, Donatien Chedom, Yau, Christopher, Jiang, Dahai, Pradeep, Sunila, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Knapp, Stefan, Gray, Nathanael S., Campo, Leticia, Myers, Kevin A., Dhar, Sunanda, Ferguson, David, Bast, Jr., Robert C., Sood, Anil K., von Delft, Frank, and Ahmed, Ahmed Ashour

Published
2018
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3. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.

Author

Yiyan Zheng, Sethi, Ritika, Mangala, Lingegowda S., Taylor, Charlotte, Goldsmith, Juliet, Ming Wang, Masuda, Kenta, Karaminejadranjbar, Mohammad, Mannion, David, Miranda, Fabrizio, Herrero-Gonzalez, Sandra, Hellner, Karin, Chen, Fiona, Alsaadi, Abdulkhaliq, Albukhari, Ashwag, Fotso, Donatien Chedom, Christopher Yau, Dahai Jiang, Pradeep, Sunila, and Rodriguez-Aguayo, Cristian

Subjects
CANCER treatment, MICROTUBULE-associated proteins, PHOSPHORYLATION, PROTEIN-tyrosine kinases, TUBULINS
Abstract

Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitaxel response has not been tested. Here, we show a previously unrecognized role of the microtubule-associated protein CRMP2 in inducing microtubule bundling through its carboxy terminus. This activity is significantly decreased when the FER tyrosine kinase phosphorylates CRMP2 at Y479 and Y499. The crystal structures of wildtype CRMP2 and CRMP2-Y479E reveal how mimicking phosphorylation prevents tetramerization of CRMP2. Depletion of FER or reducing its catalytic activity using sub-therapeutic doses of inhibitors increases paclitaxel-induced microtubule stability and cytotoxicity in ovarian cancer cells and in vivo. This work provides a rationale for inhibiting FER-mediated CRMP2 phosphorylation to enhance paclitaxel on-target activity for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2018
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