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Start Over Author "Han, Chong" Journal nature communications
12 results on '"Han, Chong"'

2. A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

Author

Tira J. Tan, W. X. Gladys Ang, Who-Whong Wang, Hui-Shan Chong, Sze Huey Tan, Rachael Cheong, John Whay-Kuang Chia, Nicholas L. Syn, Wai Ho Shuen, Rebecca Ba, Nivashini Kaliaperumal, Bijin Au, Richard Hopkins, Xinhua Li, Aaron C. Tan, Amanda O. L. Seet, John E. Connolly, Thaschawee Arkachaisri, Valerie Chew, Ahmad bin Mohamed Lajam, Dianyan Guo, Marvin Z. W. Chew, Martin Wasser, Pavanish Kumar, Salvatore Albani, and Han Chong Toh

Subjects
Science
Abstract

Ad-sig-hMUC1/ecdCD40L is a recombinant adenovirus vaccine comprising human MUC1 antigen fused to the extracellular domain of the CD40 ligand. Here the authors report the result of a phase I clinical trial of Ad-sig-hMUC1/ecdCD40L in patients with advanced adenocarcinoma.

Published
2022
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3. Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

Author

Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K. H. Chow, and Valerie Chew

Subjects
Science
Abstract

In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describe a progressive tumour-immune co-evolution programme from early to late stage cancer.

Published
2022
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5. Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, and Valerie Chew

Subjects
Science
Abstract

Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.

Published
2021
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6. Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Nguyen, Phuong H. D., Ma, Siming, Phua, Cheryl Z. J., Kaya, Neslihan A., Lai, Hannah L. H., Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony K. H., Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred W. C., Young Dan, Yock, Chung, Alexander, Bonney, Glen K., Goh, Brian K. P., Albani, Salvatore, Chow, Pierce K. H., Zhai, Weiwei, and Chew, Valerie

Published
2021
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7. A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

Author

Tan, Tira J., primary, Ang, W. X. Gladys, additional, Wang, Who-Whong, additional, Chong, Hui-Shan, additional, Tan, Sze Huey, additional, Cheong, Rachael, additional, Chia, John Whay-Kuang, additional, Syn, Nicholas L., additional, Shuen, Wai Ho, additional, Ba, Rebecca, additional, Kaliaperumal, Nivashini, additional, Au, Bijin, additional, Hopkins, Richard, additional, Li, Xinhua, additional, Tan, Aaron C., additional, Seet, Amanda O. L., additional, Connolly, John E., additional, Arkachaisri, Thaschawee, additional, Chew, Valerie, additional, Lajam, Ahmad bin Mohamed, additional, Guo, Dianyan, additional, Chew, Marvin Z. W., additional, Wasser, Martin, additional, Kumar, Pavanish, additional, Albani, Salvatore, additional, and Toh, Han Chong, additional

Published
2022
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8. Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

Author

Nguyen, Phuong H. D., primary, Wasser, Martin, additional, Tan, Chong Teik, additional, Lim, Chun Jye, additional, Lai, Hannah L. H., additional, Seow, Justine Jia Wen, additional, DasGupta, Ramanuj, additional, Phua, Cheryl Z. J., additional, Ma, Siming, additional, Yang, Jicheng, additional, Suthen, Sheena D/O, additional, Tam, Wai Leong, additional, Lim, Tony K. H., additional, Yeong, Joe, additional, Leow, Wei Qiang, additional, Pang, Yin Huei, additional, Soon, Gwyneth, additional, Loh, Tracy Jiezhen, additional, Wan, Wei Keat, additional, Chan, Chung Yip, additional, Cheow, Peng Chung, additional, Toh, Han Chong, additional, Kow, Alfred, additional, Dan, Yock Young, additional, Kam, Juinn Huar, additional, Iyer, Shridhar, additional, Madhavan, Krishnakumar, additional, Chung, Alexander, additional, Bonney, Glenn K., additional, Goh, Brian K. P., additional, Fu, Naiyang, additional, Yu, Victor C., additional, Zhai, Weiwei, additional, Albani, Salvatore, additional, Chow, Pierce K. H., additional, and Chew, Valerie, additional

Published
2022
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9. Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

Author

Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K. H. Chow, and Valerie Chew

Subjects
Mice, Multidisciplinary, Carcinoma, Hepatocellular, Liver Neoplasms, General Physics and Astronomy, Animals, Humans, General Chemistry, CD8-Positive T-Lymphocytes, Transcriptome, General Biochemistry, Genetics and Molecular Biology, Immune Evasion
Abstract

Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined. Here we show, using multi-dimensional analyses of resected tumours, their adjacent non-tumour tissues and peripheral blood, that extensive immune remodelling takes place in patients with stage I to III hepatocellular carcinoma (HCC). We demonstrate the depletion of anti-tumoural immune subsets and accumulation of immunosuppressive or exhausted subsets along with reduced tumour infiltration of CD8 T cells peaking at stage II tumours. Corresponding transcriptomic modification occur in the genes related to antigen presentation, immune responses, and chemotaxis. The progressive immune evasion is validated in a murine model of HCC. Our results show evidence of ongoing tumour-immune co-evolution during HCC progression and offer insights into potential interventions to reverse, prevent or limit the progression of the disease.

Published
2021

10. Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Liyun Lai, Neslihan A. Kaya, Tony Kiat-Hon Lim, Phuong H. D. Nguyen, Florent Ginhoux, Brian K. P. Goh, Siming Ma, Salvatore Albani, Alexander Y. F. Chung, Glen K. Bonney, Wei Qiang Leow, Weiwei Zhai, Shridhar Ganpathi Iyer, Wei Keat Wan, Chun Jye Lim, Yock Young Dan, Tracy Loh, Cheryl Zi Jin Phua, Valerie Chew, Yin Huei Pang, Pierce K. H. Chow, Martin Wasser, Jia Qi Lim, Hannah L. H. Lai, Alfred Wei Chieh Kow, Peng Chung Cheow, Han Chong Toh, Ser Yee Lee, Chung Yip Chan, and Wai Leong Tam

Subjects
0301 basic medicine, Cancer microenvironment, Carcinoma, Hepatocellular, Hepatocellular carcinoma, Science, animal diseases, General Physics and Astronomy, chemical and pharmacologic phenomena, Human leukocyte antigen, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Loss of heterozygosity, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunoediting, Carcinoma, medicine, Tumor Microenvironment, Humans, Gene Regulatory Networks, Author Correction, Survival analysis, Phylogeny, Gene Editing, Multidisciplinary, Liver Neoplasms, General Chemistry, DNA, biochemical phenomena, metabolism, and nutrition, medicine.disease, Prognosis, Phenotype, Survival Analysis, 030104 developmental biology, Treatment Outcome, 030220 oncology & carcinogenesis, Cancer research, Disease Progression, Leukocytes, Mononuclear, bacteria, RNA, Transcriptome
Abstract

The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial and phenotypic immune-ITH from multiple tumour sectors and decipher its relationship with tumour evolution and disease progression in hepatocellular carcinomas (HCC). Immune-ITH is associated with tumour transcriptomic-ITH, mutational burden and distinct immune microenvironments. Tumours with low immune-ITH experience higher immunoselective pressure and escape via loss of heterozygosity in human leukocyte antigens and immunoediting. Instead, the tumours with high immune-ITH evolve to a more immunosuppressive/exhausted microenvironment. This gradient of immune pressure along with immune-ITH represents a hallmark of tumour evolution, which is closely linked to the transcriptome-immune networks contributing to disease progression and immune inactivation. Remarkably, high immune-ITH and its transcriptomic signature are predictive for worse clinical outcome in HCC patients. This in-depth investigation of ITH provides evidence on tumour-immune co-evolution along HCC progression., Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.

Published
2020

11. Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Nguyen, Phuong H. D., primary, Ma, Siming, additional, Phua, Cheryl Z. J., additional, Kaya, Neslihan A., additional, Lai, Hannah L. H., additional, Lim, Chun Jye, additional, Lim, Jia Qi, additional, Wasser, Martin, additional, Lai, Liyun, additional, Tam, Wai Leong, additional, Lim, Tony K. H., additional, Wan, Wei Keat, additional, Loh, Tracy, additional, Leow, Wei Qiang, additional, Pang, Yin Huei, additional, Chan, Chung Yip, additional, Lee, Ser Yee, additional, Cheow, Peng Chung, additional, Toh, Han Chong, additional, Ginhoux, Florent, additional, Iyer, Shridhar, additional, Kow, Alfred W. C., additional, Young Dan, Yock, additional, Chung, Alexander, additional, Bonney, Glen K., additional, Goh, Brian K. P., additional, Albani, Salvatore, additional, Chow, Pierce K. H., additional, Zhai, Weiwei, additional, and Chew, Valerie, additional

Published
2021
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12. Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Yock Young Dan, Alexander Y. F. Chung, Brian K. P. Goh, Florent Ginhoux, Wei Keat Wan, Phuong H. D. Nguyen, Ser Yee Lee, Alfred Wei Chieh Kow, Tony Kiat-Hon Lim, Martin Wasser, Peng Chung Cheow, Wai Leong Tam, Jia Qi Lim, Chung Yip Chan, Chun Jye Lim, Shridhar Ganpathi Iyer, Salvatore Albani, Cheryl Zi Jin Phua, Wei Qiang Leow, Weiwei Zhai, Valerie Chew, Siming Ma, Glen K. Bonney, Tracy Loh, Hannah L. H. Lai, Yin Huei Pang, Han Chong Toh, Liyun Lai, Pierce K. H. Chow, and Neslihan A. Kaya

Subjects
Multidisciplinary, business.industry, Science, MEDLINE, General Physics and Astronomy, General Chemistry, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Text mining, Immune system, Hepatocellular carcinoma, medicine, Cancer research, business
Abstract

A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21556-y.

Published
2021

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