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7 results on '"Heneine, Walid"'

1. Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Author

Young, Isabella C., Massud, Ivana, Cottrell, Mackenzie L., Shrivastava, Roopali, Maturavongsadit, Panita, Prasher, Alka, Wong-Sam, Andres, Dinh, Chuong, Edwards, Tiancheng, Mrotz, Victoria, Mitchell, James, Seixas, Josilene Nascimento, Pallerla, Aryani, Thorson, Allison, Schauer, Amanda, Sykes, Craig, De la Cruz, Gabriela, Montgomery, Stephanie A., Kashuba, Angela D. M., Heneine, Walid, Dobard, Charles W., Kovarova, Martina, Garcia, J. Victor, Garcίa-Lerma, J. Gerardo, and Benhabbour, S. Rahima

Published
2024
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2. Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Author

Young, Isabella C., Massud, Ivana, Cottrell, Mackenzie L., Shrivastava, Roopali, Maturavongsadit, Panita, Prasher, Alka, Wong-Sam, Andres, Dinh, Chuong, Edwards, Tiancheng, Mrotz, Victoria, Mitchell, James, Seixas, Josilene Nascimento, Pallerla, Aryani, Thorson, Allison, Schauer, Amanda, Sykes, Craig, De la Cruz, Gabriela, Montgomery, Stephanie A., Kashuba, Angela D. M., Heneine, Walid, Dobard, Charles W., Kovarova, Martina, Garcia, J. Victor, Garcίa-Lerma, J. Gerardo, and Benhabbour, S. Rahima

Published
2023
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3. Natural selection favoring more transmissible HIV detected in United States molecular transmission network.

Author

Wertheim, Joel O, Oster, Alexandra M, Switzer, William M, Zhang, Chenhua, Panneer, Nivedha, Campbell, Ellsworth, Saduvala, Neeraja, Johnson, Jeffrey A, and Heneine, Walid

Subjects
Humans, HIV-1, HIV Infections, Viral Load, Adolescent, Adult, Middle Aged, United States, Female, Male, Young Adult, Selection, Genetic, Molecular Epidemiology, Selection, Genetic
Abstract

HIV molecular epidemiology can identify clusters of individuals with elevated rates of HIV transmission. These variable transmission rates are primarily driven by host risk behavior; however, the effect of viral traits on variable transmission rates is poorly understood. Viral load, the concentration of HIV in blood, is a heritable viral trait that influences HIV infectiousness and disease progression. Here, we reconstruct HIV genetic transmission clusters using data from the United States National HIV Surveillance System and report that viruses in clusters, inferred to be frequently transmitted, have higher viral loads at diagnosis. Further, viral load is higher in people in larger clusters and with increased network connectivity, suggesting that HIV in the United States is experiencing natural selection to be more infectious and virulent. We also observe a concurrent increase in viral load at diagnosis over the last decade. This evolutionary trajectory may be slowed by prevention strategies prioritized toward rapidly growing transmission clusters.

Published
2019

4. Using geospatial modelling to optimize the rollout of antiretroviral-based pre-exposure HIV interventions in Sub-Saharan Africa

Author

Gerberry, David J, Wagner, Bradley G, Garcia-Lerma, J Gerardo, Heneine, Walid, and Blower, Sally

Subjects
Prevention, HIV/AIDS, Infectious Diseases, Infection, Africa South of the Sahara, Anti-Retroviral Agents, Female, HIV Infections, Health Care Rationing, Humans, Incidence, Male, Models, Theoretical, Pre-Exposure Prophylaxis, Prevalence, Sex Distribution
Abstract

Antiretroviral (ARV)-based pre-exposure HIV interventions may soon be rolled out in resource-constrained Sub-Saharan African countries, but rollout plans have yet to be designed. Here we use geospatial modelling and optimization techniques to compare two rollout plans for ARV-based microbicides in South Africa: a utilitarian plan that minimizes incidence by using geographic targeting, and an egalitarian plan that maximizes geographic equity in access to interventions. We find significant geographic variation in the efficiency of interventions in reducing HIV transmission, and that efficiency increases disproportionately with increasing incidence. The utilitarian plan would result in considerable geographic inequity in access to interventions, but (by exploiting geographic variation in incidence) could prevent ~40% more infections than the egalitarian plan. Our results show that the geographic resource allocation decisions made at the beginning of a rollout, and the location where the rollout is initiated, will be crucial in determining the success of interventions in reducing HIV epidemics.

Published
2014

7. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Author

Derby, Nina, Lal, Manjari, Aravantinou, Meropi, Kizima, Larisa, Barnable, Patrick, Rodriguez, Aixa, Lai, Manshun, Wesenberg, Asa, Ugaonkar, Shweta, Levendosky, Keith, Mizenina, Olga, Kleinbeck, Kyle, Lifson, Jeffrey D., Peet, M. Melissa, Lloyd, Zachary, Benson, Michael, Heneine, Walid, O’Keefe, Barry R, Robbiani, Melissa, Martinelli, Elena, Grasperge, Brooke, Blanchard, James, Gettie, Agegnehu, Teleshova, Natalia, Fernández-Romero, José A., and Zydowsky, Thomas M.

Published
2018
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