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Your search keyword '"Isabelle Leclerc"' showing total 5 results
Start Over Author "Isabelle Leclerc" Journal nature communications
5 results on '"Isabelle Leclerc"'

1. Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Author

Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, and Guy A. Rutter

Subjects
Science
Abstract

Abstract We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two cohorts, levels of GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 are associated with faster progression, whilst SMAC/DIABLO, SPOCK1 and HEMK2 predict lower progression rates. In an external replication, proteins and lipids are associated with diabetes incidence and prevalence. NogoR/RTN4R injection improved glucose tolerance in high fat-fed male mice but impaired it in male db/db mice. High NogoR levels led to islet cell apoptosis, and IL-18R antagonised inflammatory IL-18 signalling towards nuclear factor kappa-B in vitro. This comprehensive, multi-disciplinary approach thus identifies biomarkers with potential prognostic utility, provides evidence for possible disease mechanisms, and identifies potential therapeutic avenues to slow diabetes progression.

Published
2023
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2. Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Author

Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, and Guy A. Rutter

Subjects
Science
Abstract

Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell function and intra-islet connectivity.

Published
2021
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4. Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Author

Kinga Suba, Victoria Salem, Guy A. Rutter, Elina Akalestou, Asger Wretlind, Eleni Georgiadou, Isabelle Leclerc, Pauline Chabosseau, Alasdair Gallie, Livia Lopez-Noriega, and Cristina Legido-Quigley

Subjects
Blood Glucose, Male, Intravital Microscopy, Physiology, medicine.medical_treatment, Cell, Y GASTRIC BYPASS, Bariatric Surgery, General Physics and Astronomy, Mice, 0302 clinical medicine, Glucagon-Like Peptide 1, GLYCEMIC CONTROL, Insulin-Secreting Cells, Insulin, 0303 health sciences, Multidisciplinary, geography.geographical_feature_category, Stomach, Biological techniques, Diabetes, Intravital Imaging, Islet, Multidisciplinary Sciences, medicine.anatomical_structure, Science & Technology - Other Topics, Female, medicine.medical_specialty, Sleeve gastrectomy, Science, WEIGHT-LOSS, 030209 endocrinology & metabolism, METABOLISM, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Gastrectomy, In vivo, Diabetes mellitus, parasitic diseases, Diabetes Mellitus, medicine, Animals, Humans, Secretion, 030304 developmental biology, geography, Science & Technology, business.industry, HYPERINSULINEMIC HYPOGLYCEMIA, Insulin sensitivity, PANCREATIC-ISLETS, General Chemistry, VERTICAL SLEEVE GASTRECTOMY, medicine.disease, Surgery, Mice, Inbred C57BL, GLUCOSE-HOMEOSTASIS, Calcium, POSTPRANDIAL INSULIN-SECRETION, GLP-1, business
Abstract

Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this study, we investigated the effect of Vertical Sleeve Gastrectomy (VSG) on β cell function in vivo by imaging Ca2+ dynamics in islets engrafted into the anterior eye chamber. Mirroring its clinical utility, VSG in mice results in significantly improved glucose tolerance, and enhanced insulin secretion. We reveal that these benefits are underpinned by augmented β cell function and coordinated activity across the islet. These effects involve changes in circulating GLP-1 levels which may act both directly and indirectly on the β cell, in the latter case through changes in body weight. Thus, bariatric surgery leads to time-dependent increases in β cell function and intra-islet connectivity which are likely to contribute to diabetes remission., Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell function and intra-islet connectivity.

Published
2021

5. Intravital imaging of islet Ca

Author

Elina, Akalestou, Kinga, Suba, Livia, Lopez-Noriega, Eleni, Georgiadou, Pauline, Chabosseau, Alasdair, Gallie, Asger, Wretlind, Cristina, Legido-Quigley, Isabelle, Leclerc, Victoria, Salem, and Guy A, Rutter

Subjects
Blood Glucose, Male, Intravital Microscopy, Physiology, Stomach, Biological techniques, Diabetes, Bariatric Surgery, Mice, Inbred C57BL, Mice, Gastrectomy, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Diabetes Mellitus, Animals, Humans, Insulin, Calcium, Female, Author Correction
Abstract

Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this study, we investigated the effect of Vertical Sleeve Gastrectomy (VSG) on β cell function in vivo by imaging Ca

Published
2020

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