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Start Over Author "Joseph Ipe" Journal nature communications
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1. Clinically important alterations in pharmacogene expression in histologically severe nonalcoholic fatty liver disease

Author

Nicholas R. Powell, Tiebing Liang, Joseph Ipe, Sha Cao, Todd C. Skaar, Zeruesenay Desta, Hui-Rong Qian, Philip J. Ebert, Yu Chen, Melissa K. Thomas, and Naga Chalasani

Subjects
Science
Abstract

This study characterizes expression of pharmacogenes across the histological NAFLD severity spectrum. Here, the authors show the downregulation of CYP2C19 in NAFLD which supports developing personalized medicine approaches for drugs sensitive to metabolism by the CYP2C19 enzyme.

Published
2023
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