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Your search keyword '"Karimi, Mohammad"' showing total 11 results
Start Over Author "Karimi, Mohammad" Journal nature communications
11 results on '"Karimi, Mohammad"'

3. The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus

Author

Karimi, Mohammad M., Guo, Ya, Cui, Xiaokai, Pallikonda, Husayn A., Horková, Veronika, Wang, Yi-Fang, Gil, Sara Ruiz, Rodriguez-Esteban, Gustavo, Robles-Rebollo, Irene, Bruno, Ludovica, Georgieva, Radina, Patel, Bhavik, Elliott, James, Dore, Marian H., Dauphars, Danielle, Krangel, Michael S., Lenhard, Boris, Heyn, Holger, Fisher, Amanda G., Štěpánek, Ondřej, and Merkenschlager, Matthias

Published
2021
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6. Author Correction: Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates

Author

Webster, Philip, Dawes, Joanna C., Dewchand, Hamlata, Takacs, Katalin, Iadarola, Barbara, Bolt, Bruce J., Caceres, Juan J., Kaczor, Jakub, Dharmalingam, Gopuraja, Dore, Marian, Game, Laurence, Adejumo, Thomas, Elliott, James, Naresh, Kikkeri, Karimi, Mohammad, Rekopoulou, Katerina, Tan, Ge, Paccanaro, Alberto, and Uren, Anthony G.

Published
2019
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11. LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation.

Author

Brind'Amour J, Kobayashi H, Richard Albert J, Shirane K, Sakashita A, Kamio A, Bogutz A, Koike T, Karimi MM, Lefebvre L, Kono T, and Lorincz MC

Subjects
Animals, CpG Islands genetics, DNA, Intergenic genetics, Fertilization genetics, Gene Expression Regulation, Humans, Mammals metabolism, Mice, Inbred C57BL, Polymorphism, Genetic, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Species Specificity, Synteny genetics, DNA Methylation genetics, Inheritance Patterns genetics, Oocytes metabolism, Retroelements genetics, Terminal Repeat Sequences genetics, Transcription, Genetic
Abstract

De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous even between closely related mammals, we examined whether species-specific LTR-initiated transcription units (LITs) shape the oocyte methylome. Here we identify thousands of syntenic regions in mouse, rat, and human that show divergent DNAme associated with private LITs, many of which initiate in lineage-specific LTR retrotransposons. Furthermore, CpG island (CGI) promoters methylated in mouse and/or rat, but not human oocytes, are embedded within rodent-specific LITs and vice versa. Notably, at a subset of such CGI promoters, DNAme persists on the maternal genome in fertilized and parthenogenetic mouse blastocysts or in human placenta, indicative of species-specific epigenetic inheritance. Polymorphic LITs are also responsible for disparate DNAme at promoter CGIs in distantly related mouse strains, revealing that LITs also promote intra-species divergence in CGI DNAme.

Published
2018
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