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15 results on '"Lana P"'

1. Mammals show faster recovery from capture and tagging in human-disturbed landscapes.

Author

Stiegler, Jonas, Gallagher, Cara, Hering, Robert, Müller, Thomas, Tucker, Marlee, Apollonio, Marco, Arnold, Janosch, Barker, Nancy, Barthel, Leon, Bassano, Bruno, Beest, Floris, Belant, Jerrold, Berger, Anne, Beyer, Dean, Bidner, Laura, Blake, Stephen, Börner, Konstantin, Brivio, Francesca, Brogi, Rudy, Buuveibaatar, Bayarbaatar, Cagnacci, Francesca, Dekker, Jasja, Dentinger, Jane, Duľa, Martin, Duquette, Jarred, Eccard, Jana, Evans, Meaghan, Ferguson, Adam, Fichtel, Claudia, Ford, Adam, Fowler, Nicholas, Gehr, Benedikt, Getz, Wayne, Goheen, Jacob, Goossens, Benoit, Grignolio, Stefano, Haugaard, Lars, Hauptfleisch, Morgan, Heim, Morten, Heurich, Marco, Hewison, Mark, Isbell, Lynne, Janssen, René, Jarnemo, Anders, Jeltsch, Florian, Miloš, Jezek, Kaczensky, Petra, Kamiński, Tomasz, Kappeler, Peter, Kasper, Katharina, Kautz, Todd, Kimmig, Sophia, Kjellander, Petter, Kowalczyk, Rafał, Kramer-Schadt, Stephanie, Kröschel, Max, Krop-Benesch, Anette, Linderoth, Peter, Lobas, Christoph, Lokeny, Peter, Lührs, Mia-Lana, Matsushima, Stephanie, McDonough, Molly, Melzheimer, Jörg, Morellet, Nicolas, Ngatia, Dedan, Obermair, Leopold, Olson, Kirk, Patanant, Kidan, Payne, John, Petroelje, Tyler, Pina, Manuel, Piqué, Josep, Premier, Joseph, Pufelski, Jan, Pyritz, Lennart, Ramanzin, Maurizio, Roeleke, Manuel, Rolandsen, Christer, Saïd, Sonia, Sandfort, Robin, Schmidt, Krzysztof, Schmidt, Niels, Scholz, Carolin, Schubert, Nadine, Selva, Nuria, Sergiel, Agnieszka, Serieys, Laurel, Silovský, Václav, Slotow, Rob, Sönnichsen, Leif, Solberg, Erling, Stelvig, Mikkel, Street, Garrett, Sunde, Peter, Svoboda, Nathan, Thaker, Maria, Tomowski, Maxi, Ullmann, Wiebke, and Vanak, Abi

Subjects
Animals, Humans, Mammals, Ecosystem, Male, Female, Locomotion, Herbivory, Animals, Wild, Behavior, Animal, Species Specificity
Abstract

Wildlife tagging provides critical insights into animal movement ecology, physiology, and behavior amid global ecosystem changes. However, the stress induced by capture, handling, and tagging can impact post-release locomotion and activity and, consequently, the interpretation of study results. Here, we analyze post-tagging effects on 1585 individuals of 42 terrestrial mammal species using collar-collected GPS and accelerometer data. Species-specific displacements and overall dynamic body acceleration, as a proxy for activity, were assessed over 20 days post-release to quantify disturbance intensity, recovery duration, and speed. Differences were evaluated, considering species-specific traits and the human footprint of the study region. Over 70% of the analyzed species exhibited significant behavioral changes following collaring events. Herbivores traveled farther with variable activity reactions, while omnivores and carnivores were initially less active and mobile. Recovery duration proved brief, with alterations diminishing within 4-7 tracking days for most species. Herbivores, particularly males, showed quicker displacement recovery (4 days) but slower activity recovery (7 days). Individuals in high human footprint areas displayed faster recovery, indicating adaptation to human disturbance. Our findings emphasize the necessity of extending tracking periods beyond 1 week and particular caution in remote study areas or herbivore-focused research, specifically in smaller mammals.

Published
2024

2. Base excision repair and double strand break repair cooperate to modulate the formation of unrepaired double strand breaks in mouse brain.

Author

Polyzos, Aris, Cheong, Ana, Yoo, Jung, Blagec, Lana, Toprani, Sneh, Nagel, Zachary, and McMurray, Cynthia

Subjects
Animals, DNA Breaks, Double-Stranded, DNA Repair, Mice, Brain, Mice, Inbred C57BL, Male, DNA Breaks, Single-Stranded, Female, Excision Repair
Abstract

We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of replication check points. To address these questions, here, we integrate cell-type and region-specific features of DNA repair activity in the normal brain. The brain has the same repair proteins as other tissues, but normal, canonical repair activity is unequal and is characterized by high base excision repair (BER) and low double strand break repair (DSBR). The natural imbalance creates conditions where single strand breaks (SSBs) can convert to double strand breaks (DSBs) and reversibly switch between states in response to oxidation both in vivo and in vitro. Our data suggest that, in a normal background of repair, SSBs and DSBs are in an equilibrium which is pushed or pulled by metabolic state. Interconversion of SSB to DSBs provides a physiological check point, which would allow the formation of unrepaired DSBs for productive functions, but would also restrict them from exceeding tolerable limits.

Published
2024

6. TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.

Author

Okhovat, Mariam, VanCampen, Jake, Nevonen, Kimberly, Harshman, Lana, Li, Weiyu, Layman, Cora, Ward, Samantha, Herrera, Jarod, Wells, Jackson, Sheng, Rory, Mao, Yafei, Ndjamen, Blaise, Lima, Ana, Vigh-Conrad, Katinka, Stendahl, Alexandra, Yang, Ran, Fedorov, Lev, Matthews, Ian, Easow, Sarah, Chan, Dylan, Jan, Taha, Eichler, Evan, Rugonyi, Sandra, Conrad, Donald, Carbone, Lucia, and Ahituv, Nadav

Subjects
Animals, Mice, Humans, Genomics, Genome, Gene Expression Regulation, Epigenomics, Chromatin Immunoprecipitation Sequencing, Chromatin, Mammals
Abstract

Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown. In this study, we generate Hi-C and ChIP-seq data and compare TAD organization across four primate and four rodent species and characterize the genetic and epigenetic properties of TAD boundaries in correspondence to their evolutionary conservation. We find 14% of all human TAD boundaries to be shared among all eight species (ultraconserved), while 15% are human-specific. Ultraconserved TAD boundaries have stronger insulation strength, CTCF binding, and enrichment of older retrotransposons compared to species-specific boundaries. CRISPR-Cas9 knockouts of an ultraconserved boundary in a mouse model lead to tissue-specific gene expression changes and morphological phenotypes. Deletion of a human-specific boundary near the autism-related AUTS2 gene results in the upregulation of this gene in neurons. Overall, our study provides pertinent TAD boundary evolutionary conservation annotations and showcases the functional importance of TAD evolution.

Published
2023

8. Systematic benchmarking of omics computational tools

Author

Mangul, Serghei, Martin, Lana S, Hill, Brian L, Lam, Angela Ka-Mei, Distler, Margaret G, Zelikovsky, Alex, Eskin, Eleazar, and Flint, Jonathan

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Networking and Information Technology R&D (NITRD), Generic health relevance, Benchmarking, Computational Biology, Genomics, Humans, Metabolomics, Software
Abstract

Computational omics methods packaged as software have become essential to modern biological research. The increasing dependence of scientists on these powerful software tools creates a need for systematic assessment of these methods, known as benchmarking. Adopting a standardized benchmarking practice could help researchers who use omics data to better leverage recent technological innovations. Our review summarizes benchmarking practices from 25 recent studies and discusses the challenges, advantages, and limitations of benchmarking across various domains of biology. We also propose principles that can make computational biology benchmarking studies more sustainable and reproducible, ultimately increasing the transparency of biomedical data and results.

Published
2019

9. Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Author

Kalisch-Smith, Jacinta I., Ved, Nikita, Szumska, Dorota, Munro, Jacob, Troup, Michael, Harris, Shelley E., Rodriguez-Caro, Helena, Jacquemot, Aimée, Miller, Jack J., Stuart, Eleanor M., Wolna, Magda, Hardman, Emily, Prin, Fabrice, Lana-Elola, Eva, Aoidi, Rifdat, Fisher, Elizabeth M. C., Tybulewicz, Victor L. J., Mohun, Timothy J., Lakhal-Littleton, Samira, De Val, Sarah, Giannoulatou, Eleni, and Sparrow, Duncan B.

Published
2021
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11. Attosecond electron–spin dynamics in Xe 4d photoionization

Author

Zhong, Shiyang, Vinbladh, Jimmy, Busto, David, Squibb, Richard J., Isinger, Marcus, Neoričić, Lana, Laurell, Hugo, Weissenbilder, Robin, Arnold, Cord L., Feifel, Raimund, Dahlström, Jan Marcus, Wendin, Göran, Gisselbrecht, Mathieu, Lindroth, Eva, and L’Huillier, Anne

Published
2020
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