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Start Over Author "Linnan Zhu" Journal nature communications
3 results on '"Linnan Zhu"'

1. Single cell atlas for 11 non-model mammals, reptiles and birds

Author

Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Xiran Wang, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai, Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu, Xinghuai Sun, Shenghai Zhang, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu, Yan Hua, Yahong Liu, Huan Liu, and Xun Xu

Subjects
Science
Abstract

Here the authors report single-nucleus RNA sequencing for several anatomical locations in 11 species, including cat, dog, hamster, lizard, goat, rabbit, duck, pigeon, pangolin, tiger, and deer, highlighting coexpression of SARS-CoV-2 entry factors ACE2 and TMPRSS2.

Published
2021
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2. The trans-omics landscape of COVID-19

Author

Peng Wu, Dongsheng Chen, Wencheng Ding, Ping Wu, Hongyan Hou, Yong Bai, Yuwen Zhou, Kezhen Li, Shunian Xiang, Panhong Liu, Jia Ju, Ensong Guo, Jia Liu, Bin Yang, Junpeng Fan, Liang He, Ziyong Sun, Ling Feng, Jian Wang, Tangchun Wu, Hao Wang, Jin Cheng, Hui Xing, Yifan Meng, Yongsheng Li, Yuanliang Zhang, Hongbo Luo, Gang Xie, Xianmei Lan, Ye Tao, Jiafeng Li, Hao Yuan, Kang Huang, Wan Sun, Xiaobo Qian, Zhichao Li, Mingxi Huang, Peiwen Ding, Haoyu Wang, Jiaying Qiu, Feiyue Wang, Shiyou Wang, Jiacheng Zhu, Xiangning Ding, Chaochao Chai, Langchao Liang, Xiaoling Wang, Lihua Luo, Yuzhe Sun, Ying Yang, Zhenkun Zhuang, Tao Li, Lei Tian, Shaoqiao Zhang, Linnan Zhu, Ashley Chang, Lei Chen, Yiquan Wu, Xiaoyan Ma, Fang Chen, Yan Ren, Xun Xu, Siqi Liu, Huanming Yang, Lin Wang, Chaoyang Sun, Ding Ma, Xin Jin, and Gang Chen

Subjects
Science
Abstract

COVID-19 is a critical public health threat, but molecular characterizations of patients’ immunity is still lacking. Here the authors collected blood from patients with various disease severity, and prefiltered to exclude selected comorbidity, to obtain genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles to report a trans-omics landscape.

Published
2021
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3. TSC1 controls macrophage polarization to prevent inflammatory disease

Author

Longjie Li, Yuzhu Hou, Tao Yang, Yong Zhao, Ruoyu Wang, Hongling Tian, Hongbing Zhang, Lina Sun, Lianjun Zhang, Qingjie Zhao, Lianfeng Zhang, Jianxia Peng, Zhongzhou Yang, Xuelian Hu, and Linnan Zhu

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, MAP Kinase Signaling System, Cellular differentiation, Regulator, Macrophage polarization, General Physics and Astronomy, Tuberous Sclerosis Complex 1 Protein, General Biochemistry, Genetics and Molecular Biology, Mice, Tuberous sclerosis, Tuberous Sclerosis, medicine, Animals, Cell Lineage, PI3K/AKT/mTOR pathway, Mice, Knockout, Regulation of gene expression, Multidisciplinary, Chemistry, CCAAT-Enhancer-Binding Protein-beta, Macrophages, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins, Cell Differentiation, General Chemistry, medicine.disease, Phenotype, Asthma, Cell biology, Proto-Oncogene Proteins c-raf, medicine.anatomical_structure, Gene Expression Regulation, ras GTPase-Activating Proteins, Immunology, Female, TSC1
Abstract

Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses, but the mechanisms that regulate the macrophage polarization are poorly defined. Here we show that tuberous sclerosis complex 1 (TSC1) is a critical regulator of M1 and M2 phenotypes of macrophages. Mice with myeloid-specific deletion of TSC1 exhibit enhanced M1 response and spontaneously develop M1-related inflammatory disorders. However, TSC1-deficient mice are highly resistant to M2-polarized allergic asthma. Inhibition of the mammalian target of rapamycin (mTOR) fails to reverse the hypersensitive M1 response of TSC1-deficient macrophages, but efficiently rescues the defective M2 polarization. Deletion of mTOR also fails to reverse the enhanced inflammatory response of TSC1-deficient macrophages. Molecular studies indicate that TSC1 inhibits M1 polarization by suppressing the Ras GTPase-Raf1-MEK-ERK pathway in mTOR-independent manner, whereas TSC1 promotes M2 properties by mTOR-dependent CCAAT/enhancer-binding protein-β pathways. Overall, these findings define a key role for TSC1 in orchestrating macrophage polarization via mTOR-dependent and independent pathways.

Published
2014
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