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25 results on '"Lugli, P"'

1. C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer

Author

Portale, Federica, Carriero, Roberta, Iovino, Marta, Kunderfranco, Paolo, Pandini, Marta, Marelli, Giulia, Morina, Nicolò, Lazzeri, Massimo, Casale, Paolo, Colombo, Piergiuseppe, De Simone, Gabriele, Camisaschi, Chiara, Lugli, Enrico, Basso, Gianluca, Cibella, Javier, Marchini, Sergio, Bordi, Matteo, Meregalli, Greta, Garbin, Anna, Dambra, Monica, Magrini, Elena, Rackwitz, Wiebke, Cecconi, Francesco, Corbelli, Alessandro, Fiordaliso, Fabio, Eitler, Jiri, Tonn, Torsten, and Di Mitri, Diletta

Published
2024
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2. Author Correction: Life history and ancestry of the late Upper Palaeolithic infant from Grotta delle Mura, Italy

Author

Higgins, Owen Alexander, Modi, Alessandra, Cannariato, Costanza, Diroma, Maria Angela, Lugli, Federico, Ricci, Stefano, Zaro, Valentina, Vai, Stefania, Vazzana, Antonino, Romandini, Matteo, Yu, He, Boschin, Francesco, Magnone, Luigi, Rossini, Matteo, Di Domenico, Giovanni, Baruffaldi, Fabio, Oxilia, Gregorio, Bortolini, Eugenio, Dellù, Elena, Moroni, Adriana, Ronchitelli, Annamaria, Talamo, Sahra, Müller, Wolfgang, Calattini, Mauro, Nava, Alessia, Posth, Cosimo, Lari, Martina, Bondioli, Luca, Benazzi, Stefano, and Caramelli, David

Published
2024
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3. Life history and ancestry of the late Upper Palaeolithic infant from Grotta delle Mura, Italy

Author

Higgins, Owen Alexander, Modi, Alessandra, Cannariato, Costanza, Diroma, Maria Angela, Lugli, Federico, Ricci, Stefano, Zaro, Valentina, Vai, Stefania, Vazzana, Antonino, Romandini, Matteo, Yu, He, Boschin, Francesco, Magnone, Luigi, Rossini, Matteo, Di Domenico, Giovanni, Baruffaldi, Fabio, Oxilia, Gregorio, Bortolini, Eugenio, Dellù, Elena, Moroni, Adriana, Ronchitelli, Annamaria, Talamo, Sahra, Müller, Wolfgang, Calattini, Mauro, Nava, Alessia, Posth, Cosimo, Lari, Martina, Bondioli, Luca, Benazzi, Stefano, and Caramelli, David

Published
2024
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4. C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer

Author

Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli, Anna Garbin, Monica Dambra, Elena Magrini, Wiebke Rackwitz, Francesco Cecconi, Alessandro Corbelli, Fabio Fiordaliso, Jiri Eitler, Torsten Tonn, and Diletta Di Mitri

Subjects
Science
Abstract

Abstract NK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resistance is an important immune-therapeutic aim. Here, we identify autophagy as a central regulator of NK cell anti-tumor function. Analysis of differentially expressed genes in tumor-infiltrating versus non-tumor NK cells from our previously published scRNA-seq data of advanced human prostate cancer shows deregulation of the autophagic pathway in tumor-infiltrating NK cells. We confirm this by flow cytometry in patients and in diverse cancer models in mice. We further demonstrate that exposure of NK cells to cancer deregulates the autophagic process, decreases mitochondrial polarization and impairs effector functions. Mechanistically, CCAAT enhancer binding protein beta (C/EBPβ), downstream of CXCL12-CXCR4 interaction, acts as regulator of NK cell metabolism. Accordingly, inhibition of CXCR4 and C/EBPβ restores NK cell fitness. Finally, genetic and pharmacological activation of autophagy improves NK cell effector and cytotoxic functions, which enables tumour control by NK and CAR-NK cells. In conclusion, our study identifies autophagy as an intracellular checkpoint in NK cells and introduces autophagy regulation as an approach to strengthen NK-cell-based immunotherapies.

Published
2024
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5. Life history and ancestry of the late Upper Palaeolithic infant from Grotta delle Mura, Italy

Author

Owen Alexander Higgins, Alessandra Modi, Costanza Cannariato, Maria Angela Diroma, Federico Lugli, Stefano Ricci, Valentina Zaro, Stefania Vai, Antonino Vazzana, Matteo Romandini, He Yu, Francesco Boschin, Luigi Magnone, Matteo Rossini, Giovanni Di Domenico, Fabio Baruffaldi, Gregorio Oxilia, Eugenio Bortolini, Elena Dellù, Adriana Moroni, Annamaria Ronchitelli, Sahra Talamo, Wolfgang Müller, Mauro Calattini, Alessia Nava, Cosimo Posth, Martina Lari, Luca Bondioli, Stefano Benazzi, and David Caramelli

Subjects
Science
Abstract

Abstract The biological aspects of infancy within late Upper Palaeolithic populations and the role of southern refugia at the end of the Last Glacial Maximum are not yet fully understood. This study presents a multidisciplinary, high temporal resolution investigation of an Upper Palaeolithic infant from Grotta delle Mura (Apulia, southern Italy) combining palaeogenomics, dental palaeohistology, spatially-resolved geochemical analyses, direct radiocarbon dating, and traditional anthropological studies. The skeletal remains of the infant – Le Mura 1 – were directly dated to 17,320-16,910 cal BP. The results portray a biological history of the infant’s development, early life, health and death (estimated at ~72 weeks). They identify, several phenotypic traits and a potential congenital disease in the infant, the mother’s low mobility during gestation, and a high level of endogamy. Furthermore, the genomic data indicates an early spread of the Villabruna-like components along the Italian peninsula, confirming a population turnover around the time of the Last Glacial Maximum, and highlighting a general reduction in genetic variability from northern to southern Italy. Overall, Le Mura 1 contributes to our better understanding of the early stages of life and the genetic puzzle in the Italian peninsula at the end of the Last Glacial Maximum.

Published
2024
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6. Author Correction: Life history and ancestry of the late Upper Palaeolithic infant from Grotta delle Mura, Italy

Author

Owen Alexander Higgins, Alessandra Modi, Costanza Cannariato, Maria Angela Diroma, Federico Lugli, Stefano Ricci, Valentina Zaro, Stefania Vai, Antonino Vazzana, Matteo Romandini, He Yu, Francesco Boschin, Luigi Magnone, Matteo Rossini, Giovanni Di Domenico, Fabio Baruffaldi, Gregorio Oxilia, Eugenio Bortolini, Elena Dellù, Adriana Moroni, Annamaria Ronchitelli, Sahra Talamo, Wolfgang Müller, Mauro Calattini, Alessia Nava, Cosimo Posth, Martina Lari, Luca Bondioli, Stefano Benazzi, and David Caramelli

Subjects
Science
Published
2024
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7. CRUSTY: a versatile web platform for the rapid analysis and visualization of high-dimensional flow cytometry data

Author

Simone Puccio, Giorgio Grillo, Giorgia Alvisi, Caterina Scirgolea, Giovanni Galletti, Emilia Maria Cristina Mazza, Arianna Consiglio, Gabriele De Simone, Flavio Licciulli, and Enrico Lugli

Subjects
Science
Abstract

Abstract Flow cytometry (FCM) can investigate dozens of parameters from millions of cells and hundreds of specimens in a short time and at a reasonable cost, but the amount of data that is generated is considerable. Computational approaches are useful to identify novel subpopulations and molecular biomarkers, but generally require deep expertize in bioinformatics and the use of different platforms. To overcome these limitations, we introduce CRUSTY, an interactive, user-friendly webtool incorporating the most popular algorithms for FCM data analysis, and capable of visualizing graphical and tabular results and automatically generating publication-quality figures within minutes. CRUSTY also hosts an interactive interface for the exploration of results in real time. Thus, CRUSTY enables a large number of users to mine complex datasets and reduce the time required for data exploration and interpretation. CRUSTY is accessible at https://crusty.humanitas.it/ .

Published
2023
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9. Genetic strategies for sex-biased persistence of gut microbes across human life

Author

Tarracchini, Chiara, Alessandri, Giulia, Fontana, Federico, Rizzo, Sonia Mirjam, Lugli, Gabriele Andrea, Bianchi, Massimiliano Giovanni, Mancabelli, Leonardo, Longhi, Giulia, Argentini, Chiara, Vergna, Laura Maria, Anzalone, Rosaria, Viappiani, Alice, Turroni, Francesca, Taurino, Giuseppe, Chiu, Martina, Arboleya, Silvia, Gueimonde, Miguel, Bussolati, Ovidio, van Sinderen, Douwe, Milani, Christian, and Ventura, Marco

Published
2023
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10. Genetic strategies for sex-biased persistence of gut microbes across human life

Author

Chiara Tarracchini, Giulia Alessandri, Federico Fontana, Sonia Mirjam Rizzo, Gabriele Andrea Lugli, Massimiliano Giovanni Bianchi, Leonardo Mancabelli, Giulia Longhi, Chiara Argentini, Laura Maria Vergna, Rosaria Anzalone, Alice Viappiani, Francesca Turroni, Giuseppe Taurino, Martina Chiu, Silvia Arboleya, Miguel Gueimonde, Ovidio Bussolati, Douwe van Sinderen, Christian Milani, and Marco Ventura

Subjects
Science
Abstract

Abstract Although compositional variation in the gut microbiome during human development has been extensively investigated, strain-resolved dynamic changes remain to be fully uncovered. In the current study, shotgun metagenomic sequencing data of 12,415 fecal microbiomes from healthy individuals are employed for strain-level tracking of gut microbiota members to elucidate its evolving biodiversity across the human life span. This detailed longitudinal meta-analysis reveals host sex-related persistence of strains belonging to common, maternally-inherited species, such as Bifidobacterium bifidum and Bifidobacterium longum subsp. longum. Comparative genome analyses, coupled with experiments including intimate interaction between microbes and human intestinal cells, show that specific bacterial glycosyl hydrolases related to host-glycan metabolism may contribute to more efficient colonization in females compared to males. These findings point to an intriguing ancient sex-specific host-microbe coevolution driving the selective persistence in women of key microbial taxa that may be vertically passed on to the next generation.

Published
2023
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11. GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D. Macandog, Amir Nabinejad, Carina B. Nava Lauson, Arianna Quinte’, Giovanni Bertalot, Wanda L. Petz, Simona P. Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H. Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, and Teresa Manzo

Subjects
Science
Abstract

The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce GZMK, associated with tumor progression in CRC patients.

Published
2022
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12. Author Correction: GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Tiberti, Silvia, Catozzi, Carlotta, Croci, Ottavio, Ballerini, Mattia, Cagnina, Danilo, Soriani, Chiara, Scirgolea, Caterina, Gong, Zheng, He, Jiatai, Macandog, Angeli D., Nabinejad, Amir, Nava Lauson, Carina B., Quinte’, Arianna, Bertalot, Giovanni, Petz, Wanda L., Ravenda, Simona P., Licursi, Valerio, Paci, Paola, Rasponi, Marco, Rotta, Luca, Fazio, Nicola, Ren, Guangwen, Fumagalli-Romario, Uberto, Schaefer, Martin H., Campaner, Stefano, Lugli, Enrico, Nezi, Luigi, and Manzo, Teresa

Published
2022
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13. GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Tiberti, Silvia, Catozzi, Carlotta, Croci, Ottavio, Ballerini, Mattia, Cagnina, Danilo, Soriani, Chiara, Scirgolea, Caterina, Gong, Zheng, He, Jiatai, Macandog, Angeli D., Nabinejad, Amir, Nava Lauson, Carina B., Quinte’, Arianna, Bertalot, Giovanni, Petz, Wanda L., Ravenda, Simona P., Licursi, Valerio, Paci, Paola, Rasponi, Marco, Rotta, Luca, Fazio, Nicola, Ren, Guangwen, Fumagalli-Romario, Uberto, Schaefer, Martin H., Campaner, Stefano, Lugli, Enrico, Nezi, Luigi, and Manzo, Teresa

Published
2022
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14. Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

Author

Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, and Andrea Cossarizza

Subjects
Science
Abstract

Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages show different response rates, and ICI responders have more MAIT cells expressing CXCR4 and granzyme B.

Published
2021
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15. Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Author

Hassen Kared, Shu Wen Tan, Mai Chan Lau, Marion Chevrier, Crystal Tan, Wilson How, Glenn Wong, Marie Strickland, Benoit Malleret, Amanda Amoah, Karolina Pilipow, Veronica Zanon, Naomi Mc Govern, Josephine Lum, Jin Miao Chen, Bernett Lee, Maria Carolina Florian, Hartmut Geiger, Florent Ginhoux, Ezequiel Ruiz-Mateos, Tamas Fulop, Reena Rajasuriar, Adeeba Kamarulzaman, Tze Pin Ng, Enrico Lugli, and Anis Larbi

Subjects
Science
Abstract

Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-catenin pathway as a potential therapy target.

Published
2020
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16. Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

Author

De Biasi, Sara, Gibellini, Lara, Lo Tartaro, Domenico, Puccio, Simone, Rabacchi, Claudio, Mazza, Emilia M. C., Brummelman, Jolanda, Williams, Brandon, Kaihara, Kelly, Forcato, Mattia, Bicciato, Silvio, Pinti, Marcello, Depenni, Roberta, Sabbatini, Roberto, Longo, Caterina, Dominici, Massimo, Pellacani, Giovanni, Lugli, Enrico, and Cossarizza, Andrea

Published
2021
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17. Author Correction: GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D. Macandog, Amir Nabinejad, Carina B. Nava Lauson, Arianna Quinte’, Giovanni Bertalot, Wanda L. Petz, Simona P. Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H. Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, and Teresa Manzo

Subjects
Science
Published
2022
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18. Global chromatin conformation differences in the Drosophila dosage compensated chromosome X

Author

Koustav Pal, Mattia Forcato, Daniel Jost, Thomas Sexton, Cédric Vaillant, Elisa Salviato, Emilia Maria Cristina Mazza, Enrico Lugli, Giacomo Cavalli, and Francesco Ferrari

Subjects
Science
Abstract

In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C data, indicating that dosage compensation affects global chromosome structure.

Published
2019
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19. Colonization of the human gut by bovine bacteria present in Parmesan cheese

Author

Christian Milani, Sabrina Duranti, Stefania Napoli, Giulia Alessandri, Leonardo Mancabelli, Rosaria Anzalone, Giulia Longhi, Alice Viappiani, Marta Mangifesta, Gabriele Andrea Lugli, Sergio Bernasconi, Maria Cristina Ossiprandi, Douwe van Sinderen, Marco Ventura, and Francesca Turroni

Subjects
Science
Abstract

Some microorganisms may be transferred across the food production chain and, potentially, colonize the human gut. Here, Milani et al. provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese.

Published
2019
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20. The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

Author

Vivek Bhaskaran, Michal O. Nowicki, Mahmoud Idriss, Miguel A. Jimenez, Gianmarco Lugli, Josie L. Hayes, Ahmad Bakur Mahmoud, Rachel E. Zane, Carmela Passaro, Keith L. Ligon, Daphne Haas-Kogan, Agnieszka Bronisz, Jakub Godlewski, Sean E. Lawler, E. Antonio Chiocca, and Pierpaolo Peruzzi

Subjects
Science
Abstract

The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.

Published
2019
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21. Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Author

Kared, Hassen, Tan, Shu Wen, Lau, Mai Chan, Chevrier, Marion, Tan, Crystal, How, Wilson, Wong, Glenn, Strickland, Marie, Malleret, Benoit, Amoah, Amanda, Pilipow, Karolina, Zanon, Veronica, Govern, Naomi Mc, Lum, Josephine, Chen, Jin Miao, Lee, Bernett, Florian, Maria Carolina, Geiger, Hartmut, Ginhoux, Florent, Ruiz-Mateos, Ezequiel, Fulop, Tamas, Rajasuriar, Reena, Kamarulzaman, Adeeba, Ng, Tze Pin, Lugli, Enrico, and Larbi, Anis

Published
2020
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25. A hybrid CMOS-imager with a solution-processable polymer as photoactive layer.

Author

Baierl D, Pancheri L, Schmidt M, Stoppa D, Dalla Betta GF, Scarpa G, and Lugli P

Abstract

The solution-processability of organic photodetectors allows a straightforward combination with other materials, including inorganic ones, without increasing cost and process complexity significantly compared with conventional crystalline semiconductors. Although the optoelectronic performance of these organic devices does not outmatch their inorganic counterparts, there are certain applications exploiting the benefit of the solution-processability. Here we demonstrate that the small pixel fill factor of present complementary metal oxide semiconductor-imagers, decreasing the light sensitivity, can be increased up to 100% by replacing silicon photodiodes with an organic photoactive layer deposited with a simple low-cost spray-coating process. By performing a full optoelectronic characterization on this first solution-processable hybrid complementary metal oxide semiconductor-imager, including the first reported observation of different noise types in organic photodiodes, we demonstrate the suitability of this novel device for imaging. Furthermore, by integrating monolithically different organic materials to the chip, we show the cost-effective portability of the hybrid concept to different wavelength regions.

Published
2012
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