5 results on '"Michele Sessolo"'
Search Results
2. Structural control of mixed ionic and electronic transport in conducting polymers
- Author
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Jonathan Rivnay, Sahika Inal, Brian A. Collins, Michele Sessolo, Eleni Stavrinidou, Xenofon Strakosas, Christopher Tassone, Dean M. Delongchamp, and George G. Malliaras
- Subjects
Science - Abstract
Conducting polymers are promising materials for applications including bioelectronics and soft robotics, but little is known about how morphology affects mixed conduction. Here, the authors show how bulk ionic/electronic transport is affected by changes in nano- and meso-scale structure in PEDOT:PSS films.
- Published
- 2016
- Full Text
- View/download PDF
3. Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes
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Marta Gómez-Gonzalo, Annamaria Lia, Gabriele Losi, Giorgio Carmignoto, Bernhard Bettler, Fiorenzo Conti, Iacopo Marcon, Micaela Zonta, Cécile Viollet, Michele Sessolo, Angela Chiavegato, Letizia Mariotti, Linda Maria Requie, Marcello Melone, Serena Bovetti, Angelo Forli, Arianna Pugliese, and Tommaso Fellin
- Subjects
Genetics and Molecular Biology (all) ,0301 basic medicine ,Patch-Clamp Techniques ,genetic structures ,General Physics and Astronomy ,Neocortex ,Inbred C57BL ,Biochemistry ,Transgenic ,Mice ,0302 clinical medicine ,Receptors ,lcsh:Science ,Neuronal Plasticity ,Multidisciplinary ,Somatostatin receptor ,musculoskeletal, neural, and ocular physiology ,Animals ,Astrocytes ,Calcium ,Interneurons ,Mice, Inbred C57BL ,Mice, Transgenic ,Optogenetics ,Parvalbumins ,Receptors, GABA-B ,Somatosensory Cortex ,Somatostatin ,Signal Transduction ,Chemistry (all) ,Biochemistry, Genetics and Molecular Biology (all) ,Physics and Astronomy (all) ,medicine.anatomical_structure ,GABAergic ,Astrocyte ,Interneuron ,Science ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,mental disorders ,medicine ,GABA-B ,fungi ,General Chemistry ,030104 developmental biology ,nervous system ,biology.protein ,lcsh:Q ,Neuroscience ,030217 neurology & neurosurgery ,Parvalbumin - Abstract
The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional imaging in the adult mouse neocortex, we here reveal that parvalbumin- and somatostatin-expressing interneurons, two key interneuron classes in the brain, differentially signal to astrocytes inducing weak and robust GABAB receptor-mediated Ca2+ elevations, respectively. Furthermore, the astrocyte response depresses upon parvalbumin interneuron repetitive stimulations and potentiates upon somatostatin interneuron repetitive stimulations, revealing a distinguished astrocyte plasticity. Remarkably, the potentiated response crucially depends on the neuropeptide somatostatin, released by somatostatin interneurons, which activates somatostatin receptors at astrocytic processes. Our study unveils, in the living brain, a hitherto unidentified signaling specificity between interneuron subtypes and astrocytes opening a new perspective into the role of astrocytes as non-neuronal components of inhibitory circuits., Interneurons in the neocortex have functional and morphological subtypes. Here, Mariotti and colleagues show that activation of parvalbumin-expressing interneurons evokes depressing calcium responses in astrocytes while somatostatin-expressing interneurons evoke potentiating astrocytic responses.
- Published
- 2018
- Full Text
- View/download PDF
4. Structural control of mixed ionic and electronic transport in conducting polymers
- Author
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George G. Malliaras, Jonathan Rivnay, Xenofon Strakosas, Sahika Inal, Michele Sessolo, Eleni Stavrinidou, Dean M. DeLongchamp, Brian Collins, Christopher J. Tassone, Rivnay, Jonathan [0000-0002-0602-6485], and Apollo - University of Cambridge Repository
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Conductive polymer ,Organic electronics ,0306 Physical Chemistry (incl. Structural) ,Bioelectronics ,Multidisciplinary ,Materials science ,Science ,Doping ,General Physics and Astronomy ,Ionic bonding ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,0104 chemical sciences ,Ion ,PEDOT:PSS ,Nano ,0210 nano-technology ,0912 Materials Engineering - Abstract
Poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate), PEDOT:PSS, has been utilized for over two decades as a stable, solution-processable hole conductor. While its hole transport properties have been the subject of intense investigation, recent work has turned to PEDOT:PSS as a mixed ionic/electronic conductor in applications including bioelectronics, energy storage and management, and soft robotics. Conducting polymers can efficiently transport both holes and ions when sufficiently hydrated, however, little is known about the role of morphology on mixed conduction. Here, we show that bulk ionic and electronic mobilities are simultaneously affected by processing-induced changes in nano- and meso-scale structure in PEDOT:PSS films. We quantify domain composition, and find that domain purification on addition of dispersion co-solvents limits ion mobility, even while electronic conductivity improves. We show that an optimal morphology allows for the balanced ionic and electronic transport that is critical for prototypical mixed conductor devices. These findings may pave the way for the rational design of polymeric materials and processing routes to enhance devices reliant on mixed conduction., Conducting polymers are promising materials for applications including bioelectronics and soft robotics, but little is known about how morphology affects mixed conduction. Here, the authors show how bulk ionic/electronic transport is affected by changes in nano- and meso-scale structure in PEDOT:PSS films.
- Published
- 2016
5. High transconductance organic electrochemical transistors
- Author
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Eleni Stavrinidou, M. Gurfinkel, Dion Khodagholy, Michele Sessolo, Róisín M. Owens, Sébastien Sanaur, Pierre Leleux, Georgios Malliaras, Thierry Hervé, Jonathan Rivnay, Leslie H. Jimison, Owens, Roisin [0000-0001-7856-2108], Malliaras, George [0000-0002-4582-8501], Apollo - University of Cambridge Repository, Malliaras, George, Département Bioélectronique (BEL-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-CMP-GC
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Materials science ,Fabrication ,Transistors, Electronic ,Polymers ,Transconductance ,[SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,General Physics and Astronomy ,02 engineering and technology ,Electrolyte ,Biosensing Techniques ,010402 general chemistry ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,law.invention ,Electrolytes ,law ,Hardware_INTEGRATEDCIRCUITS ,[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,ComputingMilieux_MISCELLANEOUS ,Multidisciplinary ,Ion Transport ,business.industry ,Transistor ,Electric Conductivity ,Ranging ,General Chemistry ,021001 nanoscience & nanotechnology ,Bridged Bicyclo Compounds, Heterocyclic ,Gold Compounds ,0104 chemical sciences ,Transducer ,Semiconductor ,Semiconductors ,Optoelectronics ,Polystyrenes ,0210 nano-technology ,business ,Organic electrochemical transistor - Abstract
The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical functionalization, and the ability to take on unique form factors. These devices, however, are largely viewed as belonging to the low-end of the performance spectrum. Here we present organic electrochemical transistors with a transconductance in the mS range, outperforming transistors from both traditional and emerging semiconductors. The transconductance of these devices remains fairly constant from DC up to a frequency of the order of 1 kHz, a value determined by the process of ion transport between the electrolyte and the channel. These devices, which continue to work even after being crumpled, are predicted to be highly relevant as transducers in biosensing applications., Although organic transistors have many advantages, they are not typically known for their high performance. Khodagholy et al. report the fabrication of organic electrochemical transistors that combine high transconductance with mechanical flexibility, and are attractive for biosensor applications.
- Published
- 2013
- Full Text
- View/download PDF
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