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Your search keyword '"Min-Sheng Zhu"' showing total 4 results
Start Over Author "Min-Sheng Zhu" Journal nature communications
4 results on '"Min-Sheng Zhu"'

1. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis

Author

Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, Hitomi Jin, Hyunmi Choi, Myagmar Tumenjargal, Shiyu Xie, Ji Zhang, Hina Sagae, Yanan Zhao, Rei Yamaguchi, Yu Nomura, Yuichi Shimizu, Kaito Yamada, Satoshi Yasuda, Hiroshi Kimura, Toshiya Tanaka, Youichiro Wada, Tatsuhiko Kodama, Hiroyuki Aburatani, Min-Sheng Zhu, Takeshi Inagaki, Timothy F. Osborne, Takeshi Kawamura, Yasushi Ishihama, Yoshihiro Matsumura, and Juro Sakai

Subjects
Science
Abstract

How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.

Published
2022
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2. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Author

Zhisheng Xu, Tingting Fu, Qiqi Guo, Danxia Zhou, Wanping Sun, Zheng Zhou, Xinyi Chen, Jingzi Zhang, Lin Liu, Liwei Xiao, Yujing Yin, Yuhuan Jia, Erkai Pang, Yuncong Chen, Xin Pan, Lei Fang, Min-sheng Zhu, Wenyong Fei, Bin Lu, and Zhenji Gan

Subjects
Science
Abstract

Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle causes reduced muscle mass and strength via activation of autophagy.

Published
2022
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3. The molecular basis of the genesis of basal tone in internal anal sphincter

Author

Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, and Min-Sheng Zhu

Subjects
Science
Abstract

The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a potential therapy for IAS motility disorders.

Published
2016
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4. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics

Author

Yanhua Zhai, Xue Chen, Xingjiang Yu, Zhen-Bo Wang, Dandan Qin, Ying-Chun Ouyang, Ping Zheng, Zhaohong Yi, Zheng Gao, Min-Sheng Zhu, Haibin Wang, Jurrien Dean, Lei Li, and Qing-Yuan Sun

Subjects
Zygote, Embryonic Development, Mitosis, General Physics and Astronomy, macromolecular substances, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mice, Animals, Antigens, Actin, Mice, Knockout, Multidisciplinary, Egg Proteins, Dynamics (mechanics), Proteins, RNA-Binding Proteins, General Chemistry, Actin cytoskeleton, Embryonic stem cell, Actins, Cell biology, Repressor Proteins, Actin Cytoskeleton, Actin Depolymerizing Factors, Spindle positioning, Oocytes, Co-Repressor Proteins, Cell Division
Abstract

Maternal effect genes play critical roles in early embryogenesis of model organisms where they have been intensively investigated. However, their molecular function in mammals remains largely unknown. Recently, we identified a subcortical maternal complex (SCMC) that contains four proteins encoded by maternal effect genes (Mater, Filia, Floped and Tle6). Here we report that TLE6, similar to FLOPED and MATER, stabilizes the SCMC and is necessary for cleavage beyond the two-cell stage of development. We document that the SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division of mouse zygotes. We further demonstrate that the SCMC controls formation of the actin cytoskeleton specifically via Cofilin, a key regulator of F-actin assembly. Our results provide molecular insight into the physiological function of TLE6, its interaction with the SCMC and their roles in the symmetric division of the zygote in early mouse development.

Published
2014
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