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24 results on '"P Lago"'

1. Microevolution, reinfection and highly complex genomic diversity in patients with sequential isolates of Mycobacterium abscessus

Author

Buenestado-Serrano, Sergio, Martínez-Lirola, Miguel, Herranz-Martín, Marta, Esteban, Jaime, Broncano-Lavado, Antonio, Molero-Salinas, Andrea, Sanz-Pérez, Amadeo, Blázquez, Jesús, Ruedas-López, Alba, Toro, Carlos, López-Roa, Paula, Domingo, Diego, Zamarrón, Ester, Ruiz Serrano, María Jesús, Muñoz, Patricia, Pérez-Lago, Laura, and García de Viedma, Darío

Published
2024
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2. Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Author

Michelatti, Daniela, Beyes, Sven, Bernardis, Chiara, Negri, Maria Luce, Morelli, Leonardo, Bediaga, Naiara Garcia, Poli, Vittoria, Fagnocchi, Luca, Lago, Sara, D’Annunzio, Sarah, Cona, Nicole, Gaspardo, Ilaria, Bianchi, Aurora, Jovetic, Jovana, Gianesello, Matteo, Turdo, Alice, D’Accardo, Caterina, Gaggianesi, Miriam, Dori, Martina, Forcato, Mattia, Crispatzu, Giuliano, Rada-Iglesias, Alvaro, Sosa, Maria Soledad, Timmers, H. T. Marc, Bicciato, Silvio, Todaro, Matilde, Tiberi, Luca, and Zippo, Alessio

Published
2024
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4. Microevolution, reinfection and highly complex genomic diversity in patients with sequential isolates of Mycobacterium abscessus

Author

Sergio Buenestado-Serrano, Miguel Martínez-Lirola, Marta Herranz-Martín, Jaime Esteban, Antonio Broncano-Lavado, Andrea Molero-Salinas, Amadeo Sanz-Pérez, Jesús Blázquez, Alba Ruedas-López, Carlos Toro, Paula López-Roa, Diego Domingo, Ester Zamarrón, María Jesús Ruiz Serrano, Patricia Muñoz, Laura Pérez-Lago, and Darío García de Viedma

Subjects
Science
Abstract

Abstract Mycobacterium abscessus is an opportunistic, extensively drug-resistant non-tuberculous mycobacterium. Few genomic studies consider its diversity in persistent infections. Our aim was to characterize microevolution/reinfection events in persistent infections. Fifty-three sequential isolates from 14 patients were sequenced to determine SNV-based distances, assign resistance mutations and characterize plasmids. Genomic analysis revealed 12 persistent cases (0-13 differential SNVs), one reinfection (15,956 SNVs) and one very complex case (23 sequential isolates over 192 months), in which a first period of persistence (58 months) involving the same genotype 1 was followed by identification of a genotype 2 (76 SNVs) in 6 additional alternating isolates; additionally, ten transient genotypes (88-243 SNVs) were found. A macrolide resistance mutation was identified from the second isolate. Despite high diversity, the genotypes shared a common phylogenetic ancestor and some coexisted in the same specimens. Genomic analysis is required to access the true intra-patient complexity behind persistent infections involving M. abscessus.

Published
2024
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5. Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Author

Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri, Leonardo Morelli, Naiara Garcia Bediaga, Vittoria Poli, Luca Fagnocchi, Sara Lago, Sarah D’Annunzio, Nicole Cona, Ilaria Gaspardo, Aurora Bianchi, Jovana Jovetic, Matteo Gianesello, Alice Turdo, Caterina D’Accardo, Miriam Gaggianesi, Martina Dori, Mattia Forcato, Giuliano Crispatzu, Alvaro Rada-Iglesias, Maria Soledad Sosa, H. T. Marc Timmers, Silvio Bicciato, Matilde Todaro, Luca Tiberi, and Alessio Zippo

Subjects
Science
Abstract

Abstract Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before giving rise to symptomatic overt metastasis. In this context, DTCs fluctuate between a quiescent and proliferative state in response to systemic and microenvironmental signals including immune-mediated surveillance. Despite its relevance, how intrinsic mechanisms sustain DTCs plasticity has not been addressed. By interrogating the epigenetic state of metastatic cells, we find that tumour progression is coupled with the activation of oncogenic enhancers that are organized in variable interconnected chromatin domains. This spatial chromatin context leads to the activation of a robust transcriptional response upon repeated exposure to retinoic acid (RA). We show that this adaptive mechanism sustains the quiescence of DTCs through the activation of the master regulator SOX9. Finally, we determine that RA-stimulated transcriptional memory increases the fitness of metastatic cells by supporting the escape of quiescent DTCs from NK-mediated immune surveillance. Overall, these findings highlight the contribution of oncogenic enhancers in establishing transcriptional memories as an adaptive mechanism to reinforce cancer dormancy and immune escape, thus amenable for therapeutic intervention.

Published
2024
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6. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force

Author

Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C. Luca, Björn Reinius, Ana I. Teixeira, and Björn Högberg

Subjects
Science
Abstract

Abstract The Notch signaling pathway has fundamental roles in embryonic development and in the nervous system. The current model of receptor activation involves initiation via a force-induced conformational change. Here, we define conditions that reveal pulling force-independent Notch activation using soluble multivalent constructs. We treat neuroepithelial stem-like cells with molecularly precise ligand nanopatterns displayed from solution using DNA origami. Notch signaling follows with clusters of Jag1, and with chimeric structures where most Jag1 proteins are replaced by other binders not targeting Notch. Our data rule out several confounding factors and suggest a model where Jag1 activates Notch upon prolonged binding without appearing to need a pulling force. These findings reveal a distinct mode of activation of Notch and lay the foundation for the development of soluble agonists.

Published
2024
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7. Learning few-shot imitation as cultural transmission

Author

Bhoopchand, Avishkar, Brownfield, Bethanie, Collister, Adrian, Dal Lago, Agustin, Edwards, Ashley, Everett, Richard, Fréchette, Alexandre, Oliveira, Yanko Gitahy, Hughes, Edward, Mathewson, Kory W., Mendolicchio, Piermaria, Pawar, Julia, Pȋslar, Miruna, Platonov, Alex, Senter, Evan, Singh, Sukhdeep, Zacherl, Alexander, and Zhang, Lei M.

Published
2023
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10. Learning few-shot imitation as cultural transmission

Author

Avishkar Bhoopchand, Bethanie Brownfield, Adrian Collister, Agustin Dal Lago, Ashley Edwards, Richard Everett, Alexandre Fréchette, Yanko Gitahy Oliveira, Edward Hughes, Kory W. Mathewson, Piermaria Mendolicchio, Julia Pawar, Miruna Pȋslar, Alex Platonov, Evan Senter, Sukhdeep Singh, Alexander Zacherl, and Lei M. Zhang

Subjects
Science
Abstract

Abstract Cultural transmission is the domain-general social skill that allows agents to acquire and use information from each other in real-time with high fidelity and recall. It can be thought of as the process that perpetuates fit variants in cultural evolution. In humans, cultural evolution has led to the accumulation and refinement of skills, tools and knowledge across generations. We provide a method for generating cultural transmission in artificially intelligent agents, in the form of few-shot imitation. Our agents succeed at real-time imitation of a human in novel contexts without using any pre-collected human data. We identify a surprisingly simple set of ingredients sufficient for generating cultural transmission and develop an evaluation methodology for rigorously assessing it. This paves the way for cultural evolution to play an algorithmic role in the development of artificial general intelligence.

Published
2023
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11. Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Author

Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, and Marlene Rabinovitch

Subjects
Science
Abstract

Abstract Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human PAEC with reduced BMPR2 have persistent DNA damage in room air after hypoxia (reoxygenation), as do mice with EC-specific deletion of Bmpr2 (EC-Bmpr2 -/-) and persistent pulmonary hypertension. Similar findings are observed in PAEC with loss of the DNA damage sensor ATM, and in mice with Atm deleted in EC (EC-Atm -/-). Gene expression analysis of EC-Atm -/- and EC-Bmpr2 -/- lung EC reveals reduced Foxf1, a transcription factor with selectivity for lung EC. Reducing FOXF1 in control PAEC induces DNA damage and impaired angiogenesis whereas transfection of FOXF1 in PAH PAEC repairs DNA damage and restores angiogenesis. Lung EC targeted delivery of Foxf1 to reoxygenated EC-Bmpr2 -/- mice repairs DNA damage, induces angiogenesis and reverses pulmonary hypertension.

Published
2023
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12. Global assessment of marine plastic exposure risk for oceanic birds

Author

Bethany L. Clark, Ana P. B. Carneiro, Elizabeth J. Pearmain, Marie-Morgane Rouyer, Thomas A. Clay, Win Cowger, Richard A. Phillips, Andrea Manica, Carolina Hazin, Marcus Eriksen, Jacob González-Solís, Josh Adams, Yuri V. Albores-Barajas, Joanna Alfaro-Shigueto, Maria Saldanha Alho, Deusa Teixeira Araujo, José Manuel Arcos, John P. Y. Arnould, Nadito J. P. Barbosa, Christophe Barbraud, Annalea M. Beard, Jessie Beck, Elizabeth A. Bell, Della G. Bennet, Maud Berlincourt, Manuel Biscoito, Oskar K. Bjørnstad, Mark Bolton, Katherine A. Booth Jones, John J. Borg, Karen Bourgeois, Vincent Bretagnolle, Joël Bried, James V. Briskie, M. de L. Brooke, Katherine C. Brownlie, Leandro Bugoni, Licia Calabrese, Letizia Campioni, Mark J. Carey, Ryan D. Carle, Nicholas Carlile, Ana R. Carreiro, Paulo Catry, Teresa Catry, Jacopo G. Cecere, Filipe R. Ceia, Yves Cherel, Chang-Yong Choi, Marco Cianchetti-Benedetti, Rohan H. Clarke, Jaimie B. Cleeland, Valentina Colodro, Bradley C. Congdon, Jóhannis Danielsen, Federico De Pascalis, Zoe Deakin, Nina Dehnhard, Giacomo Dell’Omo, Karine Delord, Sébastien Descamps, Ben J. Dilley, Herculano A. Dinis, Jerome Dubos, Brendon J. Dunphy, Louise M. Emmerson, Ana Isabel Fagundes, Annette L. Fayet, Jonathan J. Felis, Johannes H. Fischer, Amanda N. D. Freeman, Aymeric Fromant, Giorgia Gaibani, David García, Carina Gjerdrum, Ivandra Soeli Gonçalves Correia Gomes, Manuela G. Forero, José P. Granadeiro, W. James Grecian, David Grémillet, Tim Guilford, Gunnar Thor Hallgrimsson, Luke R. Halpin, Erpur Snær Hansen, April Hedd, Morten Helberg, Halfdan H. Helgason, Leeann M. Henry, Hannah F. R. Hereward, Marcos Hernandez-Montero, Mark A. Hindell, Peter J. Hodum, Simona Imperio, Audrey Jaeger, Mark Jessopp, Patrick G. R. Jodice, Carl G. Jones, Christopher W. Jones, Jón Einar Jónsson, Adam Kane, Sven Kapelj, Yuna Kim, Holly Kirk, Yann Kolbeinsson, Philipp L. Kraemer, Lucas Krüger, Paulo Lago, Todd J. Landers, Jennifer L. Lavers, Matthieu Le Corre, Andreia Leal, Maite Louzao, Jeremy Madeiros, Maria Magalhães, Mark L. Mallory, Juan F. Masello, Bruno Massa, Sakiko Matsumoto, Fiona McDuie, Laura McFarlane Tranquilla, Fernando Medrano, Benjamin J. Metzger, Teresa Militão, William A. Montevecchi, Rosalinda C. Montone, Leia Navarro-Herrero, Verónica C. Neves, David G. Nicholls, Malcolm A. C. Nicoll, Ken Norris, Steffen Oppel, Daniel Oro, Ellie Owen, Oliver Padget, Vítor H. Paiva, David Pala, Jorge M. Pereira, Clara Péron, Maria V. Petry, Admilton de Pina, Ariete T. Moreira Pina, Patrick Pinet, Pierre A. Pistorius, Ingrid L. Pollet, Benjamin J. Porter, Timothée A. Poupart, Christopher D. L. Powell, Carolina B. Proaño, Júlia Pujol-Casado, Petra Quillfeldt, John L. Quinn, Andre F. Raine, Helen Raine, Iván Ramírez, Jaime A. Ramos, Raül Ramos, Andreas Ravache, Matt J. Rayner, Timothy A. Reid, Gregory J. Robertson, Gerard J. Rocamora, Dominic P. Rollinson, Robert A. Ronconi, Andreu Rotger, Diego Rubolini, Kevin Ruhomaun, Asunción Ruiz, James C. Russell, Peter G. Ryan, Sarah Saldanha, Ana Sanz-Aguilar, Mariona Sardà-Serra, Yvan G. Satgé, Katsufumi Sato, Wiebke C. Schäfer, Stefan Schoombie, Scott A. Shaffer, Nirmal Shah, Akiko Shoji, Dave Shutler, Ingvar A. Sigurðsson, Mónica C. Silva, Alison E. Small, Cecilia Soldatini, Hallvard Strøm, Christopher A. Surman, Akinori Takahashi, Vikash R. V. Tatayah, Graeme A. Taylor, Robert J. Thomas, David R. Thompson, Paul M. Thompson, Thorkell L. Thórarinsson, Diego Vicente-Sastre, Eric Vidal, Ewan D. Wakefield, Susan M. Waugh, Henri Weimerskirch, Heiko U. Wittmer, Takashi Yamamoto, Ken Yoda, Carlos B. Zavalaga, Francis J. Zino, and Maria P. Dias

Subjects
Science
Abstract

Abstract Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species.

Published
2023
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13. Deep optoacoustic localization microangiography of ischemic stroke in mice

Author

Xosé Luís Deán-Ben, Justine Robin, Daniil Nozdriukhin, Ruiqing Ni, Jim Zhao, Chaim Glück, Jeanne Droux, Juan Sendón-Lago, Zhenyue Chen, Quanyu Zhou, Bruno Weber, Susanne Wegener, Anxo Vidal, Michael Arand, Mohamad El Amki, and Daniel Razansky

Subjects
Science
Abstract

Abstract Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible dichloromethane-based microdroplets exhibiting several orders of magnitude higher optical absorption than red blood cells at near-infrared wavelengths, thus enabling single-particle detection in vivo. We demonstrate non-invasive three-dimensional microangiography of the mouse brain beyond the acoustic diffraction limit (

Published
2023
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18. Modeling medulloblastoma in vivo and with human cerebellar organoids

Author

Ballabio, Claudio, Anderle, Marica, Gianesello, Matteo, Lago, Chiara, Miele, Evelina, Cardano, Marina, Aiello, Giuseppe, Piazza, Silvano, Caron, Davide, Gianno, Francesca, Ciolfi, Andrea, Pedace, Lucia, Mastronuzzi, Angela, Tartaglia, Marco, Locatelli, Franco, Ferretti, Elisabetta, Giangaspero, Felice, and Tiberi, Luca

Published
2020
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19. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling

Author

Pedro Machado Almeida, Blanca Lago Solis, Luca Stickley, Alexis Feidler, and Emi Nagoshi

Subjects
Science
Abstract

The molecular mechanism by which clock neurons transmit timing information to non-clock neurons is poorly understood. Here, the authors show that circadian clocks drive rhythmic expression of hundreds of genes in mushroom body neurons and drive calcium rhythms via NF1-cAMP/PKAC1 signalling in Drosophila.

Published
2021
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20. Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

Author

Sara Lago, Matteo Nadai, Filippo M. Cernilogar, Maryam Kazerani, Helena Domíniguez Moreno, Gunnar Schotta, and Sara N. Richter

Subjects
Science
Abstract

G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determine cell-specific transcriptional programs.

Published
2021
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21. Particle number-based trophic transfer of gold nanomaterials in an aquatic food chain

Author

Fazel Abdolahpur Monikh, Latifeh Chupani, Daniel Arenas-Lago, Zhiling Guo, Peng Zhang, Gopala Krishna Darbha, Eugenia Valsami-Jones, Iseult Lynch, Martina G. Vijver, Peter M. van Bodegom, and Willie J.G.M. Peijnenburg

Subjects
Science
Abstract

Biological fate of nanomaterials in organisms is an important topic, however, limitations of analytical techniques has hampered understanding. Here, the authors report on a study into the fate of model, gold nanoparticles in an aquatic food chain using an analytical workflow and range of analytical methods.

Published
2021
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22. Modeling medulloblastoma in vivo and with human cerebellar organoids

Author

Claudio Ballabio, Marica Anderle, Matteo Gianesello, Chiara Lago, Evelina Miele, Marina Cardano, Giuseppe Aiello, Silvano Piazza, Davide Caron, Francesca Gianno, Andrea Ciolfi, Lucia Pedace, Angela Mastronuzzi, Marco Tartaglia, Franco Locatelli, Elisabetta Ferretti, Felice Giangaspero, and Luca Tiberi

Subjects
Science
Abstract

Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human cerebellar organoids where Otx2/c-MYC give rise to MB-like organoids harboring a DNA methylation signature that clusters with human Group 3 tumors. Furthermore, we show that SMARCA4 is able to reduce Otx2/c-MYC tumorigenic activity in vivo and in human cerebellar organoids while SMARCA4 T910M, a mutant form found in human MB patients, inhibits the wild-type protein function. Finally, treatment with Tazemetostat, a EZH2-specific inhibitor, reduces Otx2/c-MYC tumorigenesis in ex vivo culture and human cerebellar organoids. In conclusion, human cerebellar organoids can be efficiently used to understand the role of genes found altered in cancer patients and represent a reliable tool for developing personalized therapies.

Published
2020
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23. A non-canonical mismatch repair pathway in prokaryotes

Author

A. Castañeda-García, A. I. Prieto, J. Rodríguez-Beltrán, N. Alonso, D. Cantillon, C. Costas, L. Pérez-Lago, E. D. Zegeye, M. Herranz, P. Plociński, T. Tonjum, D. García de Viedma, M. Paget, S. J. Waddell, A. M. Rojas, A. J. Doherty, and J. Blázquez

Subjects
Science
Abstract

Despite the importance of mismatch repair for genome stability, many Archaea and almost all Actinobacteria lack MutS and MutL proteins. Here the authors, usingMycobacterium smegmatisas a model, report that NucS/EndoMS endonuclease acts in a distinct mismatch repair pathway.

Published
2017
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24. Global assessment of marine plastic exposure risk for oceanic birds.

Author

Clark BL, Carneiro APB, Pearmain EJ, Rouyer MM, Clay TA, Cowger W, Phillips RA, Manica A, Hazin C, Eriksen M, González-Solís J, Adams J, Albores-Barajas YV, Alfaro-Shigueto J, Alho MS, Araujo DT, Arcos JM, Arnould JPY, Barbosa NJP, Barbraud C, Beard AM, Beck J, Bell EA, Bennet DG, Berlincourt M, Biscoito M, Bjørnstad OK, Bolton M, Booth Jones KA, Borg JJ, Bourgeois K, Bretagnolle V, Bried J, Briskie JV, Brooke ML, Brownlie KC, Bugoni L, Calabrese L, Campioni L, Carey MJ, Carle RD, Carlile N, Carreiro AR, Catry P, Catry T, Cecere JG, Ceia FR, Cherel Y, Choi CY, Cianchetti-Benedetti M, Clarke RH, Cleeland JB, Colodro V, Congdon BC, Danielsen J, De Pascalis F, Deakin Z, Dehnhard N, Dell'Omo G, Delord K, Descamps S, Dilley BJ, Dinis HA, Dubos J, Dunphy BJ, Emmerson LM, Fagundes AI, Fayet AL, Felis JJ, Fischer JH, Freeman AND, Fromant A, Gaibani G, García D, Gjerdrum C, Gomes ISGC, Forero MG, Granadeiro JP, Grecian WJ, Grémillet D, Guilford T, Hallgrimsson GT, Halpin LR, Hansen ES, Hedd A, Helberg M, Helgason HH, Henry LM, Hereward HFR, Hernandez-Montero M, Hindell MA, Hodum PJ, Imperio S, Jaeger A, Jessopp M, Jodice PGR, Jones CG, Jones CW, Jónsson JE, Kane A, Kapelj S, Kim Y, Kirk H, Kolbeinsson Y, Kraemer PL, Krüger L, Lago P, Landers TJ, Lavers JL, Le Corre M, Leal A, Louzao M, Madeiros J, Magalhães M, Mallory ML, Masello JF, Massa B, Matsumoto S, McDuie F, McFarlane Tranquilla L, Medrano F, Metzger BJ, Militão T, Montevecchi WA, Montone RC, Navarro-Herrero L, Neves VC, Nicholls DG, Nicoll MAC, Norris K, Oppel S, Oro D, Owen E, Padget O, Paiva VH, Pala D, Pereira JM, Péron C, Petry MV, de Pina A, Pina ATM, Pinet P, Pistorius PA, Pollet IL, Porter BJ, Poupart TA, Powell CDL, Proaño CB, Pujol-Casado J, Quillfeldt P, Quinn JL, Raine AF, Raine H, Ramírez I, Ramos JA, Ramos R, Ravache A, Rayner MJ, Reid TA, Robertson GJ, Rocamora GJ, Rollinson DP, Ronconi RA, Rotger A, Rubolini D, Ruhomaun K, Ruiz A, Russell JC, Ryan PG, Saldanha S, Sanz-Aguilar A, Sardà-Serra M, Satgé YG, Sato K, Schäfer WC, Schoombie S, Shaffer SA, Shah N, Shoji A, Shutler D, Sigurðsson IA, Silva MC, Small AE, Soldatini C, Strøm H, Surman CA, Takahashi A, Tatayah VRV, Taylor GA, Thomas RJ, Thompson DR, Thompson PM, Thórarinsson TL, Vicente-Sastre D, Vidal E, Wakefield ED, Waugh SM, Weimerskirch H, Wittmer HU, Yamamoto T, Yoda K, Zavalaga CB, Zino FJ, and Dias MP

Subjects
Animals, Environmental Monitoring, Oceans and Seas, Birds, Indian Ocean, Plastics toxicity, Waste Products analysis
Abstract

Plastic pollution is distributed patchily around the world's oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species., (© 2023. The Author(s).)

Published
2023
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