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Start Over Author "P. Bennet" Journal nature communications
15 results on '"P. Bennet"'

2. Global assessment of marine plastic exposure risk for oceanic birds.

Author

Clark, Bethany, Carneiro, Ana, Pearmain, Elizabeth, Rouyer, Marie-Morgane, Clay, Thomas, Cowger, Win, Phillips, Richard, Manica, Andrea, Hazin, Carolina, Eriksen, Marcus, González-Solís, Jacob, Adams, Josh, Albores-Barajas, Yuri, Alfaro-Shigueto, Joanna, Alho, Maria, Araujo, Deusa, Arcos, José, Arnould, John, Barbosa, Nadito, Barbraud, Christophe, Beard, Annalea, Beck, Jessie, Bell, Elizabeth, Bennet, Della, Berlincourt, Maud, Biscoito, Manuel, Bjørnstad, Oskar, Bolton, Mark, Booth Jones, Katherine, Borg, John, Bourgeois, Karen, Bretagnolle, Vincent, Bried, Joël, Briskie, James, Brooke, M, Brownlie, Katherine, Bugoni, Leandro, Calabrese, Licia, Campioni, Letizia, Carey, Mark, Carle, Ryan, Carlile, Nicholas, Carreiro, Ana, Catry, Paulo, Catry, Teresa, Cecere, Jacopo, Ceia, Filipe, Cherel, Yves, Choi, Chang-Yong, Cianchetti-Benedetti, Marco, Clarke, Rohan, Cleeland, Jaimie, Colodro, Valentina, Congdon, Bradley, Danielsen, Jóhannis, De Pascalis, Federico, Deakin, Zoe, Dehnhard, Nina, DellOmo, Giacomo, Delord, Karine, Descamps, Sébastien, Dilley, Ben, Dinis, Herculano, Dubos, Jerome, Dunphy, Brendon, Emmerson, Louise, Fagundes, Ana, Fayet, Annette, Felis, Jonathan, Fischer, Johannes, Freeman, Amanda, Fromant, Aymeric, Gaibani, Giorgia, García, David, Gjerdrum, Carina, Gomes, Ivandra, Forero, Manuela, Granadeiro, José, Grecian, W, Grémillet, David, Guilford, Tim, Hallgrimsson, Gunnar, Halpin, Luke, Hansen, Erpur, Hedd, April, Helberg, Morten, Helgason, Halfdan, Henry, Leeann, Hereward, Hannah, Hernandez-Montero, Marcos, Hindell, Mark, Hodum, Peter, Imperio, Simona, Jaeger, Audrey, Jessopp, Mark, Jodice, Patrick, Jones, Carl, Jones, Christopher, Jónsson, Jón, and Kane, Adam

Subjects
Animals, Plastics, Waste Products, Environmental Monitoring, Oceans and Seas, Birds, Indian Ocean
Abstract

Plastic pollution is distributed patchily around the worlds oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species.

Published
2023

3. Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model

Author

Uchida, Naoya, Stasula, Ulana, Demirci, Selami, Germino-Watnick, Paula, Hinds, Malikiya, Le, Anh, Chu, Rebecca, Berg, Alexander, Liu, Xiong, Su, Ling, Wu, Xiaolin, Krouse, Allen E., Linde, N. Seth, Bonifacino, Aylin, Hong, So Gun, Dunbar, Cynthia E., Lanieri, Leanne, Bhat, Anjali, Palchaudhuri, Rahul, Bennet, Bindu, Hoban, Megan, Bertelsen, Kirk, Olson, Lisa M., Donahue, Robert E., and Tisdale, John F.

Published
2023
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5. PGRL2 triggers degradation of PGR5 in the absence of PGRL1

Author

Thilo Rühle, Marcel Dann, Bennet Reiter, Danja Schünemann, Belen Naranjo, Jan-Ferdinand Penzler, Tatjana Kleine, and Dario Leister

Subjects
Science
Abstract

It is currently thought that the thylakoid proteins PGRL1 and PGR5 form a complex to mediate cyclic electron flow (CEF) around photosystem I. Here the authors show that CEF can in fact be mediated by PGR5 alone and that PGRL1 and the homologous PGRL2 modify the process by modulating PGR5 activity and stability.

Published
2021
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7. Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Author

Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, and Andrew J. Bennet

Subjects
Science
Abstract

Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and structural basis of their inhibitory activity.

Published
2018
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8. A vacuole-like compartment concentrates a disordered calcium phase in a key coccolithophorid alga

Author

Sanja Sviben, Assaf Gal, Matthew A. Hood, Luca Bertinetti, Yael Politi, Mathieu Bennet, Praveen Krishnamoorthy, Andreas Schertel, Richard Wirth, Andrea Sorrentino, Eva Pereiro, Damien Faivre, and André Scheffel

Subjects
Science
Abstract

Coccolithophores are unicellular marine algae that produce calcitic particles inside their cells. Here the authors study cells of the dominant coccolithophore Emiliania huxleyiand identify an intracellular compartment that is filled with high concentrations of a disordered form of calcium.

Published
2016
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11. Author Correction: Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Author

Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, and Andrew J. Bennet

Subjects
Science
Abstract

In the originally published version of this Article, the affiliation details for Tracey M. Gloster were incorrectly given as 'Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada'. The correct affiliation is 'Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK'. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2018
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12. An organic proton cage that is ultra-resistant to hydroxide-promoted degradation

Author

Chase L. Radford, Torben Saatkamp, Andrew J. Bennet, and Steven Holdcroft

Subjects
Science
Abstract

Abstract Alkaline polymer membrane electrochemical energy conversion devices offer the prospect of using non-platinum group catalysts. However, their cationic functionalities are currently not sufficiently stable for vapor-phase applications, such as fuel cells. Herein, we report 1,6-diazabicyclo[4.4.4]tetradecan-1,6-ium (in-DBD), a cationic proton cage, that is orders of magnitude more resistant to hydroxide-promoted degradation than state-of-the-art organic cations under ultra-dry conditions and elevated temperature, and the first organic cation-hydroxide to persist at critically low hydration levels (

Published
2024
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13. Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model

Author

Naoya Uchida, Ulana Stasula, Selami Demirci, Paula Germino-Watnick, Malikiya Hinds, Anh Le, Rebecca Chu, Alexander Berg, Xiong Liu, Ling Su, Xiaolin Wu, Allen E. Krouse, N. Seth Linde, Aylin Bonifacino, So Gun Hong, Cynthia E. Dunbar, Leanne Lanieri, Anjali Bhat, Rahul Palchaudhuri, Bindu Bennet, Megan Hoban, Kirk Bertelsen, Lisa M. Olson, Robert E. Donahue, and John F. Tisdale

Subjects
Science
Abstract

Abstract Hematopoietic stem cell (HSC) gene therapy has curative potential; however, its use is limited by the morbidity and mortality associated with current chemotherapy-based conditioning. Targeted conditioning using antibody-drug conjugates (ADC) holds promise for reduced toxicity in HSC gene therapy. Here we test the ability of an antibody-drug conjugate targeting CD117 (CD117-ADC) to enable engraftment in a non-human primate lentiviral gene therapy model of hemoglobinopathies. Following single-dose CD117-ADC, a >99% depletion of bone marrow CD34 + CD90 + CD45RA- cells without lymphocyte reduction is observed, which results are not inferior to multi-day myeloablative busulfan conditioning. CD117-ADC, similarly to busulfan, allows efficient engraftment, gene marking, and vector-derived fetal hemoglobin induction. Importantly, ADC treatment is associated with minimal toxicity, and CD117-ADC-conditioned animals maintain fertility. In contrast, busulfan treatment commonly causes severe toxicities and infertility in humans. Thus, the myeloablative capacity of single-dose CD117-ADC is sufficient for efficient engraftment of gene-modified HSCs while preserving fertility and reducing adverse effects related to toxicity in non-human primates. This targeted conditioning approach thus provides the proof-of-principle to improve risk-benefit ratio in a variety of HSC-based gene therapy products in humans.

Published
2023
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14. Global assessment of marine plastic exposure risk for oceanic birds

Author

Bethany L. Clark, Ana P. B. Carneiro, Elizabeth J. Pearmain, Marie-Morgane Rouyer, Thomas A. Clay, Win Cowger, Richard A. Phillips, Andrea Manica, Carolina Hazin, Marcus Eriksen, Jacob González-Solís, Josh Adams, Yuri V. Albores-Barajas, Joanna Alfaro-Shigueto, Maria Saldanha Alho, Deusa Teixeira Araujo, José Manuel Arcos, John P. Y. Arnould, Nadito J. P. Barbosa, Christophe Barbraud, Annalea M. Beard, Jessie Beck, Elizabeth A. Bell, Della G. Bennet, Maud Berlincourt, Manuel Biscoito, Oskar K. Bjørnstad, Mark Bolton, Katherine A. Booth Jones, John J. Borg, Karen Bourgeois, Vincent Bretagnolle, Joël Bried, James V. Briskie, M. de L. Brooke, Katherine C. Brownlie, Leandro Bugoni, Licia Calabrese, Letizia Campioni, Mark J. Carey, Ryan D. Carle, Nicholas Carlile, Ana R. Carreiro, Paulo Catry, Teresa Catry, Jacopo G. Cecere, Filipe R. Ceia, Yves Cherel, Chang-Yong Choi, Marco Cianchetti-Benedetti, Rohan H. Clarke, Jaimie B. Cleeland, Valentina Colodro, Bradley C. Congdon, Jóhannis Danielsen, Federico De Pascalis, Zoe Deakin, Nina Dehnhard, Giacomo Dell’Omo, Karine Delord, Sébastien Descamps, Ben J. Dilley, Herculano A. Dinis, Jerome Dubos, Brendon J. Dunphy, Louise M. Emmerson, Ana Isabel Fagundes, Annette L. Fayet, Jonathan J. Felis, Johannes H. Fischer, Amanda N. D. Freeman, Aymeric Fromant, Giorgia Gaibani, David García, Carina Gjerdrum, Ivandra Soeli Gonçalves Correia Gomes, Manuela G. Forero, José P. Granadeiro, W. James Grecian, David Grémillet, Tim Guilford, Gunnar Thor Hallgrimsson, Luke R. Halpin, Erpur Snær Hansen, April Hedd, Morten Helberg, Halfdan H. Helgason, Leeann M. Henry, Hannah F. R. Hereward, Marcos Hernandez-Montero, Mark A. Hindell, Peter J. Hodum, Simona Imperio, Audrey Jaeger, Mark Jessopp, Patrick G. R. Jodice, Carl G. Jones, Christopher W. Jones, Jón Einar Jónsson, Adam Kane, Sven Kapelj, Yuna Kim, Holly Kirk, Yann Kolbeinsson, Philipp L. Kraemer, Lucas Krüger, Paulo Lago, Todd J. Landers, Jennifer L. Lavers, Matthieu Le Corre, Andreia Leal, Maite Louzao, Jeremy Madeiros, Maria Magalhães, Mark L. Mallory, Juan F. Masello, Bruno Massa, Sakiko Matsumoto, Fiona McDuie, Laura McFarlane Tranquilla, Fernando Medrano, Benjamin J. Metzger, Teresa Militão, William A. Montevecchi, Rosalinda C. Montone, Leia Navarro-Herrero, Verónica C. Neves, David G. Nicholls, Malcolm A. C. Nicoll, Ken Norris, Steffen Oppel, Daniel Oro, Ellie Owen, Oliver Padget, Vítor H. Paiva, David Pala, Jorge M. Pereira, Clara Péron, Maria V. Petry, Admilton de Pina, Ariete T. Moreira Pina, Patrick Pinet, Pierre A. Pistorius, Ingrid L. Pollet, Benjamin J. Porter, Timothée A. Poupart, Christopher D. L. Powell, Carolina B. Proaño, Júlia Pujol-Casado, Petra Quillfeldt, John L. Quinn, Andre F. Raine, Helen Raine, Iván Ramírez, Jaime A. Ramos, Raül Ramos, Andreas Ravache, Matt J. Rayner, Timothy A. Reid, Gregory J. Robertson, Gerard J. Rocamora, Dominic P. Rollinson, Robert A. Ronconi, Andreu Rotger, Diego Rubolini, Kevin Ruhomaun, Asunción Ruiz, James C. Russell, Peter G. Ryan, Sarah Saldanha, Ana Sanz-Aguilar, Mariona Sardà-Serra, Yvan G. Satgé, Katsufumi Sato, Wiebke C. Schäfer, Stefan Schoombie, Scott A. Shaffer, Nirmal Shah, Akiko Shoji, Dave Shutler, Ingvar A. Sigurðsson, Mónica C. Silva, Alison E. Small, Cecilia Soldatini, Hallvard Strøm, Christopher A. Surman, Akinori Takahashi, Vikash R. V. Tatayah, Graeme A. Taylor, Robert J. Thomas, David R. Thompson, Paul M. Thompson, Thorkell L. Thórarinsson, Diego Vicente-Sastre, Eric Vidal, Ewan D. Wakefield, Susan M. Waugh, Henri Weimerskirch, Heiko U. Wittmer, Takashi Yamamoto, Ken Yoda, Carlos B. Zavalaga, Francis J. Zino, and Maria P. Dias

Subjects
Science
Abstract

Abstract Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species.

Published
2023
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15. An ancient metabolite damage-repair system sustains photosynthesis in plants

Author

Dario Leister, Anurag Sharma, Natalia Kerber, Thomas Nägele, Bennet Reiter, Viviana Pasch, Simon Beeh, Peter Jahns, Roberto Barbato, Mathias Pribil, and Thilo Rühle

Subjects
Science
Abstract

Abstract Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the major catalyst in the conversion of carbon dioxide into organic compounds in photosynthetic organisms. However, its activity is impaired by binding of inhibitory sugars such as xylulose-1,5-bisphosphate (XuBP), which must be detached from the active sites by Rubisco activase. Here, we show that loss of two phosphatases in Arabidopsis thaliana has detrimental effects on plant growth and photosynthesis and that this effect could be reversed by introducing the XuBP phosphatase from Rhodobacter sphaeroides. Biochemical analyses revealed that the plant enzymes specifically dephosphorylate XuBP, thus allowing xylulose-5-phosphate to enter the Calvin-Benson-Bassham cycle. Our findings demonstrate the physiological importance of an ancient metabolite damage-repair system in degradation of by-products of Rubisco, and will impact efforts to optimize carbon fixation in photosynthetic organisms.

Published
2023
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