15 results on '"Shang, Lin"'
Search Results
2. Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling
- Author
-
Fu-Lung Yeh, Shang-Lin Chang, Golam Rizvee Ahmed, Hsin-I Liu, Luh Tung, Chung-Shu Yeh, Leah Stands Lanier, Corina Maeder, Che-Min Lin, Shu-Chun Tsai, Wan-Yi Hsiao, Wei-Hau Chang, and Tien-Hsien Chang
- Subjects
Science - Abstract
Yeast helicase Prp28 promotes the first step of spliceosome remodeling. By placing a photoactivatable unnatural amino acid in Prp28, the authors capture Prp28 in action revealing its dynamic interactions and cofactor Npl3.
- Published
- 2021
- Full Text
- View/download PDF
3. Large polarization gradients and temperature-stable responses in compositionally-graded ferroelectrics.
- Author
-
Damodaran, Anoop R, Pandya, Shishir, Qi, Yubo, Hsu, Shang-Lin, Liu, Shi, Nelson, Christopher, Dasgupta, Arvind, Ercius, Peter, Ophus, Colin, Dedon, Liv R, Agar, Josh C, Lu, Hongling, Zhang, Jialan, Minor, Andrew M, Rappe, Andrew M, and Martin, Lane W
- Abstract
A range of modern applications require large and tunable dielectric, piezoelectric or pyroelectric response of ferroelectrics. Such effects are intimately connected to the nature of polarization and how it responds to externally applied stimuli. Ferroelectric susceptibilities are, in general, strongly temperature dependent, diminishing rapidly as one transitions away from the ferroelectric phase transition (TC). In turn, researchers seek new routes to manipulate polarization to simultaneously enhance susceptibilities and broaden operational temperature ranges. Here, we demonstrate such a capability by creating composition and strain gradients in Ba1-xSrxTiO3 films which result in spatial polarization gradients as large as 35 μC cm-2 across a 150 nm thick film. These polarization gradients allow for large dielectric permittivity with low loss (ɛr≈775, tan δ
- Published
- 2017
4. The role of CO2 in the genesis of Dabie-type porphyry molybdenum deposits.
- Author
-
Jiang, Zi-Qi, Shang, Lin-Bo, Williams-Jones, A. E., Wang, Xin-Song, Zhang, Li, Ni, Huai-Wei, Hu, Rui-Zhong, and Bi, Xian-Wu
- Subjects
PORPHYRY ,MOLYBDENUM ,MAGMAS ,SALT ,VAPORS ,FLUIDS - Abstract
Porphyry-type molybdenum deposits, many of which are in China, supply most of the World's molybdenum. Of particular importance are the molybdenum deposits located in the Qinling-Dabie region that are responsible for more than half of China's molybdenum production. A feature that distinguishes this suite of deposits from the better-known Climax and Endako sub-types of porphyry molybdenum deposits is their formation from CO
2 -rich magmatic-hydrothermal fluids. The role of CO2 , if any, in the transport of molybdenum by these fluids, however, is poorly understood. We conducted experiments on the partitioning of molybdenum between H2 O-CO2 , H2 O-NaCl, and H2 O-NaCl-CO2 fluids and a felsic melt at 850 °C and 100 and 200 MPa. Here we show that the exsolution of separate (immiscible) brine and vapor leads to the very high brine DMo values needed for efficient extraction of Mo from the magmas forming Dabie-type porphyry molybdenum deposits. Direct exsolution of immiscible CO2 vapour and brine from magma greatly enriches the brine in molybdenum, a likely factor in the genesis of the Dabie-type porphyry deposits that supply much of the World's molybdenum [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
5. Single crystal functional oxides on silicon.
- Author
-
Bakaul, Saidur Rahman, Serrao, Claudy Rayan, Lee, Michelle, Yeung, Chun Wing, Sarker, Asis, Hsu, Shang-Lin, Yadav, Ajay Kumar, Dedon, Liv, You, Long, Khan, Asif Islam, Clarkson, James David, Hu, Chenming, Ramesh, Ramamoorthy, and Salahuddin, Sayeef
- Abstract
Single-crystalline thin films of complex oxides show a rich variety of functional properties such as ferroelectricity, piezoelectricity, ferro and antiferromagnetism and so on that have the potential for completely new electronic applications. Direct synthesis of such oxides on silicon remains challenging because of the fundamental crystal chemistry and mechanical incompatibility of dissimilar interfaces. Here we report integration of thin (down to one unit cell) single crystalline, complex oxide films onto silicon substrates, by epitaxial transfer at room temperature. In a field-effect transistor using a transferred lead zirconate titanate layer as the gate insulator, we demonstrate direct reversible control of the semiconductor channel charge with polarization state. These results represent the realization of long pursued but yet to be demonstrated single-crystal functional oxides on-demand on silicon.
- Published
- 2016
6. Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling
- Author
-
Yeh, Fu-Lung, Chang, Shang-Lin, Ahmed, Golam Rizvee, Liu, Hsin-I, Tung, Luh, Yeh, Chung-Shu, Lanier, Leah Stands, Maeder, Corina, Lin, Che-Min, Tsai, Shu-Chun, Hsiao, Wan-Yi, Chang, Wei-Hau, and Chang, Tien-Hsien
- Published
- 2021
- Full Text
- View/download PDF
7. Large polarization gradients and temperature-stable responses in compositionally-graded ferroelectrics
- Author
-
Anoop R. Damodaran, Shishir Pandya, Yubo Qi, Shang-Lin Hsu, Shi Liu, Christopher Nelson, Arvind Dasgupta, Peter Ercius, Colin Ophus, Liv R. Dedon, Josh C. Agar, Hongling Lu, Jialan Zhang, Andrew M. Minor, Andrew M. Rappe, and Lane W. Martin
- Subjects
Science - Abstract
Future technologies based on ferroelectric materials will require new routes to control the nature of polar order. Through a combined experimental and theoretical study of compositionally and strain-graded Ba1-xSrxTiO3 heterostructures, Damodaranet al. demonstrate the ability to engineer large polarization gradients and temperature-stable susceptibilities.
- Published
- 2017
- Full Text
- View/download PDF
8. Single crystal functional oxides on silicon
- Author
-
Saidur Rahman Bakaul, Claudy Rayan Serrao, Michelle Lee, Chun Wing Yeung, Asis Sarker, Shang-Lin Hsu, Ajay Kumar Yadav, Liv Dedon, Long You, Asif Islam Khan, James David Clarkson, Chenming Hu, Ramamoorthy Ramesh, and Sayeef Salahuddin
- Subjects
Science - Abstract
Synthesis of single-crystal complex-oxide films directly on silicon is difficult due to differing interfacial chemistry. Here, the authors demonstrate room-temperature integration of single-crystal lead zirconate titanate on to silicon to act as a gate insulator in a field-effect transistor.
- Published
- 2016
- Full Text
- View/download PDF
9. Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling
- Author
-
Che-Min Lin, Shu-Chun Tsai, Tien-Hsien Chang, Luh Tung, Hsin-I Liu, Wei-Hau Chang, Chung-Shu Yeh, Leah Stands Lanier, Golam Rizvee Ahmed, Corina Maeder, Fu-Lung Yeh, Wan-Yi Hsiao, and Shang-Lin Chang
- Subjects
0301 basic medicine ,Spliceosome ,Saccharomyces cerevisiae Proteins ,RNA splicing ,ATPase ,Science ,Ribonuclease H ,General Physics and Astronomy ,Saccharomyces cerevisiae ,General Biochemistry, Genetics and Molecular Biology ,Article ,DEAD-box RNA Helicases ,03 medical and health sciences ,Exon ,0302 clinical medicine ,Adenosine Triphosphate ,RNA Precursors ,Humans ,snRNP ,Phosphorylation ,Ribonucleoprotein ,Messenger RNA ,Multidisciplinary ,biology ,Chemistry ,Intron ,Nuclear Proteins ,RNA-Binding Proteins ,General Chemistry ,Ribonucleoproteins, Small Nuclear ,Cell biology ,030104 developmental biology ,Multiprotein Complexes ,Mutation ,biology.protein ,Spliceosomes ,RNA ,030217 neurology & neurosurgery ,RNA Helicases ,Protein Binding - Abstract
Splicing, a key step in the eukaryotic gene-expression pathway, converts precursor messenger RNA (pre-mRNA) into mRNA by excising introns and ligating exons. This task is accomplished by the spliceosome, a macromolecular machine that must undergo sequential conformational changes to establish its active site. Each of these major changes requires a dedicated DExD/H-box ATPase, but how these enzymes are activated remain obscure. Here we show that Prp28, a yeast DEAD-box ATPase, transiently interacts with the conserved 5′ splice-site (5′SS) GU dinucleotide and makes splicing-dependent contacts with the U1 snRNP protein U1C, and U4/U6.U5 tri-snRNP proteins, Prp8, Brr2, and Snu114. We further show that Prp28’s ATPase activity is potentiated by the phosphorylated Npl3, but not the unphosphorylated Npl3, thus suggesting a strategy for regulating DExD/H-box ATPases. We propose that Npl3 is a functional counterpart of the metazoan-specific Prp28 N-terminal region, which can be phosphorylated and serves as an anchor to human spliceosome., Yeast helicase Prp28 promotes the first step of spliceosome remodeling. By placing a photoactivatable unnatural amino acid in Prp28, the authors capture Prp28 in action revealing its dynamic interactions and cofactor Npl3.
- Published
- 2021
10. Quantification of flexoelectricity in PbTiO3/SrTiO3 superlattice polar vortices using machine learning and phase-field modeling
- Author
-
Sergei V. Kalinin, Shang-Lin Hsu, Ramamoorthy Ramesh, Lane W. Martin, Ajay K. Yadav, Anoop R. Damodaran, Qian Li, Martin D. McCarter, Christopher T. Nelson, and Li Li
- Subjects
Superlattice ,Science ,Flexoelectricity ,General Physics and Astronomy ,02 engineering and technology ,01 natural sciences ,Imaging data ,General Biochemistry, Genetics and Molecular Biology ,Article ,Condensed Matter::Materials Science ,Polar vortex ,0103 physical sciences ,010306 general physics ,lcsh:Science ,Physics ,Multidisciplinary ,Condensed matter physics ,Coupling strength ,General Chemistry ,021001 nanoscience & nanotechnology ,Polarization (waves) ,Vortex ,Polarization density ,Classical mechanics ,lcsh:Q ,0210 nano-technology - Abstract
Flexoelectricity refers to electric polarization generated by heterogeneous mechanical strains, namely strain gradients, in materials of arbitrary crystal symmetries. Despite more than 50 years of work on this effect, an accurate identification of its coupling strength remains an experimental challenge for most materials, which impedes its wide recognition. Here, we show the presence of flexoelectricity in the recently discovered polar vortices in PbTiO3/SrTiO3 superlattices based on a combination of machine-learning analysis of the atomic-scale electron microscopy imaging data and phenomenological phase-field modeling. By scrutinizing the influence of flexocoupling on the global vortex structure, we match theory and experiment using computer vision methodologies to determine the flexoelectric coefficients for PbTiO3 and SrTiO3. Our findings highlight the inherent, nontrivial role of flexoelectricity in the generation of emergent complex polarization morphologies and demonstrate a viable approach to delineating this effect, conducive to the deeper exploration of both topics., Flexoelectric coupling between strain gradients and polarization influences the physics of ferroelectric devices but it is difficult to directly probe its effects. Here, Li et al. use principal component analysis to compare STEM images with phase-field modeling and extract the flexoelectric contributions.
- Published
- 2017
11. Large polarization gradients and temperature-stable responses in compositionally-graded ferroelectrics
- Author
-
Andrew M. Minor, Lane W. Martin, Andrew M. Rappe, H. Lu, Peter Ercius, Shishir Pandya, Christopher T. Nelson, Josh C. Agar, Arvind Dasgupta, Colin Ophus, Shang-Lin Hsu, Jialan Zhang, Yubo Qi, Anoop R. Damodaran, Liv R. Dedon, and Shi Liu
- Subjects
010302 applied physics ,Phase transition ,Multidisciplinary ,Materials science ,Condensed matter physics ,Science ,Dielectric permittivity ,General Physics and Astronomy ,02 engineering and technology ,General Chemistry ,Dielectric ,021001 nanoscience & nanotechnology ,Polarization (waves) ,Operation temperature ,01 natural sciences ,Piezoelectricity ,Ferroelectricity ,Article ,General Biochemistry, Genetics and Molecular Biology ,Pyroelectricity ,0103 physical sciences ,0210 nano-technology - Abstract
A range of modern applications require large and tunable dielectric, piezoelectric or pyroelectric response of ferroelectrics. Such effects are intimately connected to the nature of polarization and how it responds to externally applied stimuli. Ferroelectric susceptibilities are, in general, strongly temperature dependent, diminishing rapidly as one transitions away from the ferroelectric phase transition (TC). In turn, researchers seek new routes to manipulate polarization to simultaneously enhance susceptibilities and broaden operational temperature ranges. Here, we demonstrate such a capability by creating composition and strain gradients in Ba1−xSrxTiO3 films which result in spatial polarization gradients as large as 35 μC cm−2 across a 150 nm thick film. These polarization gradients allow for large dielectric permittivity with low loss (ɛr≈775, tan δ, Future technologies based on ferroelectric materials will require new routes to control the nature of polar order. Through a combined experimental and theoretical study of compositionally and strain-graded Ba1-xSrxTiO3 heterostructures, Damodaran et al. demonstrate the ability to engineer large polarization gradients and temperature-stable susceptibilities.
- Published
- 2017
12. Electrically reversible cracks in an intermetallic film controlled by an electric field
- Author
-
Juzhe Liu, Z.X. Feng, Michael D. Biegalski, Chengbao Jiang, Ramamoorthy Ramesh, Cassie Marker, Shun Li Shang, Yanzhou Ji, Robert O. Ritchie, Anthony T. Wong, Thomas Z. Ward, Long You, Shang-Lin Hsu, H. Yan, Long Qing Chen, Jia Mian Hu, Zhiqi Liu, Megan J. Cordill, Hans M. Christen, Ming-Wei Lin, Zi Kui Liu, Bernd Gludovatz, and Jinliang Wang
- Subjects
010302 applied physics ,Multidisciplinary ,Materials science ,Science ,Intermetallic ,General Physics and Astronomy ,02 engineering and technology ,General Chemistry ,Substrate (electronics) ,021001 nanoscience & nanotechnology ,01 natural sciences ,Ferroelectricity ,Article ,General Biochemistry, Genetics and Molecular Biology ,Catastrophic failure ,Electric field ,0103 physical sciences ,lcsh:Q ,Thin film ,Composite material ,lcsh:Science ,0210 nano-technology ,Nanoscopic scale ,Voltage - Abstract
Cracks in solid-state materials are typically irreversible. Here we report electrically reversible opening and closing of nanoscale cracks in an intermetallic thin film grown on a ferroelectric substrate driven by a small electric field (~0.83 kV/cm). Accordingly, a nonvolatile colossal electroresistance on–off ratio of more than 108 is measured across the cracks in the intermetallic film at room temperature. Cracks are easily formed with low-frequency voltage cycling and remain stable when the device is operated at high frequency, which offers intriguing potential for next-generation high-frequency memory applications. Moreover, endurance testing demonstrates that the opening and closing of such cracks can reach over 107 cycles under 10-μs pulses, without catastrophic failure of the film., Electric-field-induced cracks are generally detrimental to functionality of ferroelectric ceramics. Liu et al. use an intermetallic alloy and ferroelectric oxide junction to mediate the reversible formation of cracks at nanoscales, resulting in colossal electroresistance modulation for memory applications.
- Published
- 2018
13. Single crystal functional oxides on silicon
- Author
-
Chenming Hu, Liv R. Dedon, Michelle Lee, Ramamoorthy Ramesh, Long You, Chun Wing Yeung, Shang-Lin Hsu, Ajay K. Yadav, Asif Islam Khan, Saidur Rahman Bakaul, Claudy Serrao, Sayeef Salahuddin, James D. Clarkson, and Asis Sarker
- Subjects
Materials science ,Silicon ,Crystal chemistry ,Science ,General Physics and Astronomy ,chemistry.chemical_element ,FOS: Physical sciences ,02 engineering and technology ,Lead zirconate titanate ,Epitaxy ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,chemistry.chemical_compound ,0103 physical sciences ,Thin film ,010302 applied physics ,Condensed Matter - Materials Science ,Multidisciplinary ,business.industry ,Materials Science (cond-mat.mtrl-sci) ,General Chemistry ,021001 nanoscience & nanotechnology ,equipment and supplies ,Ferroelectricity ,Semiconductor ,chemistry ,Optoelectronics ,0210 nano-technology ,business ,Single crystal - Abstract
Single-crystalline thin films of complex oxides show a rich variety of functional properties such as ferroelectricity, piezoelectricity, ferro and antiferromagnetism and so on that have the potential for completely new electronic applications. Direct synthesis of such oxides on silicon remains challenging because of the fundamental crystal chemistry and mechanical incompatibility of dissimilar interfaces. Here we report integration of thin (down to one unit cell) single crystalline, complex oxide films onto silicon substrates, by epitaxial transfer at room temperature. In a field-effect transistor using a transferred lead zirconate titanate layer as the gate insulator, we demonstrate direct reversible control of the semiconductor channel charge with polarization state. These results represent the realization of long pursued but yet to be demonstrated single-crystal functional oxides on-demand on silicon., Synthesis of single-crystal complex-oxide films directly on silicon is difficult due to differing interfacial chemistry. Here, the authors demonstrate room-temperature integration of single-crystal lead zirconate titanate on to silicon to act as a gate insulator in a field-effect transistor.
- Published
- 2015
14. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion
- Author
-
Li, Wei-Guang, primary, Liu, Ming-Gang, additional, Deng, Shining, additional, Liu, Yan-Mei, additional, Shang, Lin, additional, Ding, Jing, additional, Hsu, Tsan-Ting, additional, Jiang, Qin, additional, Li, Ying, additional, Li, Fei, additional, Zhu, Michael Xi, additional, and Xu, Tian-Le, additional
- Published
- 2016
- Full Text
- View/download PDF
15. Large resistivity modulation in mixed-phase metallic systems
- Author
-
John T. Heron, Ramamoorthy Ramesh, Ulrich Aschauer, Jeongmin Hong, James D. Clarkson, Jeffrey Bokor, Yeonbae Lee, Changhyun Ko, Nicola A. Spaldin, Hans M. Christen, Sayeef Salahuddin, Darrell G. Schlom, Junqiao Wu, Zhiqi Liu, Mark E. Nowakowski, Shang-Lin Hsu, and Michael D. Biegalski
- Subjects
Multidisciplinary ,Condensed matter physics ,General Physics and Astronomy ,Heterojunction ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology ,Metal ,Magnetization ,Modulation ,Electrical resistivity and conductivity ,visual_art ,Electric field ,visual_art.visual_art_medium ,Mixed phase - Abstract
In numerous systems, giant physical responses have been discovered when two phases coexist; for example, near a phase transition. An intermetallic FeRh system undergoes a first-order antiferromagnetic to ferromagnetic transition above room temperature and shows two-phase coexistence near the transition. Here we have investigated the effect of an electric field to FeRh/PMN-PT heterostructures and report 8% change in the electrical resistivity of FeRh films. Such a 'giant' electroresistance (GER) response is striking in metallic systems, in which external electric fields are screened, and thus only weakly influence the carrier concentrations and mobilities. We show that our FeRh films comprise coexisting ferromagnetic and antiferromagnetic phases with different resistivities and the origin of the GER effect is the strain-mediated change in their relative proportions. The observed behaviour is reminiscent of colossal magnetoresistance in perovskite manganites and illustrates the role of mixed-phase coexistence in achieving large changes in physical properties with low-energy external perturbation.
- Published
- 2014
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.