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Your search keyword '"Smith, CATHERINE H."' showing total 7 results
Start Over Author "Smith, CATHERINE H." Journal nature communications
7 results on '"Smith, CATHERINE H."'

2. Genome-wide association meta-analysis identifies 29 new acne susceptibility loci

Author

Mitchell, Brittany L., Saklatvala, Jake R., Dand, Nick, Hagenbeek, Fiona A., Li, Xin, Min, Josine L., Thomas, Laurent, Bartels, Meike, Jan Hottenga, Jouke, Lupton, Michelle K., Boomsma, Dorret I., Dong, Xianjun, Hveem, Kristian, Løset, Mari, Martin, Nicholas G., Barker, Jonathan N., Han, Jiali, Smith, Catherine H., Rentería, Miguel E., and Simpson, Michael A.

Published
2022
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3. Author Correction: Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis

Author

Andres-Ejarque, Rosa, Ale, Hira Bahadur, Grys, Katarzyna, Tosi, Isabella, Solanky, Shane, Ainali, Chrysanthi, Catak, Zeynep, Sreeneebus, Hemawtee, Saklatvala, Jake, Dand, Nick, de Rinaldis, Emanuele, Chapman, Anna, Nestle, Frank O., Barnes, Michael R., Warren, Richard B., Reynolds, Nick J., Griffiths, Christopher E. M., Barker, Jonathan N., Smith, Catherine H., and Di Meglio, Paola

Published
2021
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4. Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis

Author

Andres-Ejarque, Rosa, Ale, Hira Bahadur, Grys, Katarzyna, Tosi, Isabella, Solanky, Shane, Ainali, Chrysanthi, Catak, Zeynep, Sreeneebus, Hemawtee, Saklatvala, Jake, Dand, Nick, de Rinaldis, Emanuele, Chapman, Anna, Nestle, Frank O., Barnes, Michael R., Warren, Richard B., Reynolds, Nick J., Griffiths, Christopher E. M., Barker, Jonathan N., Smith, Catherine H., and Di Meglio, Paola

Published
2021
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5. Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Author

Petridis, Christos, Navarini, Alexander A., Dand, Nick, Saklatvala, Jake, Baudry, David, Duckworth, Michael, Allen, Michael H., Curtis, Charles J., Lee, Sang Hyuck, Burden, A. David, Layton, Alison, Bataille, Veronique, Pink, Andrew E., The Acne Genetic Study Group, Carlavan, Isabelle, Voegel, Johannes J., Spector, Timothy D., Trembath, Richard C., McGrath, John A., Smith, Catherine H., Barker, Jonathan N., and Simpson, Michael A.

Published
2018
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6. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

Author

Tziotzios, Christos, primary, Petridis, Christos, additional, Dand, Nick, additional, Ainali, Chrysanthi, additional, Saklatvala, Jake R., additional, Pullabhatla, Venu, additional, Onoufriadis, Alexandros, additional, Pramanik, Rashida, additional, Baudry, David, additional, Lee, Sang Hyuck, additional, Wood, Kristie, additional, Liu, Lu, additional, Seegobin, Seth, additional, Michelotti, Gregory A., additional, Lwin, Su M., additional, Christou, Evangelos A. A., additional, Curtis, Charles J., additional, de Rinaldis, Emanuele, additional, Saxena, Alka, additional, Holmes, Susan, additional, Harries, Matthew, additional, Palamaras, Ioulios, additional, Cunningham, Fiona, additional, Parkins, Gregory, additional, Kaur, Manjit, additional, Farrant, Paul, additional, McDonagh, Andrew, additional, Messenger, Andrew, additional, Jones, Jennifer, additional, Jolliffe, Victoria, additional, Ali, Iaisha, additional, Ardern-Jones, Michael, additional, Mitchell, Charles, additional, Burrows, Nigel, additional, Atkar, Ravinder, additional, Banfield, Cedric, additional, Alexandroff, Anton, additional, Champagne, Caroline, additional, Cooper, Hywel L., additional, Vañó-Galván, Sergio, additional, Molina-Ruiz, Ana Maria, additional, Perez, Nerea Ormaechea, additional, Patel, Girish K., additional, Macbeth, Abby, additional, Page, Melanie, additional, Bryden, Alyson, additional, Mowbray, Megan, additional, Wahie, Shyamal, additional, Armstrong, Keith, additional, Cooke, Nicola, additional, Goodfield, Mark, additional, Man, Irene, additional, de Berker, David, additional, Dunnill, Giles, additional, Takwale, Anita, additional, Rao, Archana, additional, Siah, Tee-Wei, additional, Sinclair, Rodney, additional, Wade, Martin S., additional, Dlova, Ncoza C., additional, Setterfield, Jane, additional, Lewis, Fiona, additional, Bhargava, Kapil, additional, Kirkpatrick, Niall, additional, Estivill, Xavier, additional, Stefanato, Catherine M., additional, Flohr, Carsten, additional, Spector, Timothy, additional, Watt, Fiona M., additional, Smith, Catherine H., additional, Barker, Jonathan N., additional, Fenton, David A., additional, Simpson, Michael A., additional, and McGrath, John A., additional

Published
2019
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7. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.

Author

Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, Willis C, Déret S, Voegel JJ, Spector T, Smith CH, Trembath RC, and Barker JN

Subjects
Adult, Case-Control Studies, DNA-Binding Proteins genetics, Female, Follistatin genetics, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Transcription Factors genetics, Transforming Growth Factor beta2 genetics, Young Adult, Acne Vulgaris genetics, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract

Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous pilo-sebaceous unit. Here we perform a genome-wide association analysis in the United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132). In a second stage, we genotype putative-associated loci in a further 2,063 acne cases and 1,970 controls. We identify three genome-wide significant associations: 11q13.1 (rs478304, Pcombined=3.23 × 10(-11), odds ratio (OR) = 1.20), 5q11.2 (rs38055, P(combined) = 4.58 × 10(-9), OR = 1.17) and 1q41 (rs1159268, P(combined) = 4.08 × 10(-8), OR = 1.17). All three loci contain genes linked to the TGFβ cell signalling pathway, namely OVOL1, FST and TGFB2. Transcripts of OVOL1 and TFGB2 have decreased expression in affected compared with normal skin. Collectively, these data support a key role for dysregulation of TGFβ-mediated signalling in susceptibility to acne.

Published
2014
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