Search

Your search keyword '"Tan AT"' showing total 5,002 results
Start Over Author "Tan AT" Journal nature communications
5,002 results on '"Tan AT"'

1. Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery.

Author

Tan, Jessica, Servellita, Venice, Stryke, Doug, Kelly, Emily, Streithorst, Jessica, Sumimoto, Nanami, Foresythe, Abiodun, Huh, Hee, Nguyen, Jenny, Oseguera, Miriam, Brazer, Noah, Tang, Jack, Ingebrigtsen, Danielle, Fung, Becky, Reyes, Helen, Hillberg, Melissa, Chen, Alice, Guevara, Hugo, Yagi, Shigeo, Morales, Christina, Wadford, Debra, Mourani, Peter, Langelier, Charles, de Lorenzi-Tognon, Mikael, Benoit, Patrick, and Chiu, Charles

Subjects
Humans, High-Throughput Nucleotide Sequencing, Metagenomics, Respiratory Tract Infections, Viruses, Female, Adult, Middle Aged, Male, Sensitivity and Specificity, Bronchoalveolar Lavage Fluid, Aged, Child, Adolescent, Young Adult, Viral Load, Child, Preschool
Abstract

Tools for rapid identification of novel and/or emerging viruses are urgently needed for clinical diagnosis of unexplained infections and pandemic preparedness. Here we developed and clinically validated a largely automated metagenomic next-generation sequencing (mNGS) assay for agnostic detection of respiratory viral pathogens from upper respiratory swab and bronchoalveolar lavage samples in

Published
2024

2. Long-lived topological time-crystalline order on a quantum processor.

Author

Xiang, Liang, Jiang, Wenjie, Bao, Zehang, Song, Zixuan, Xu, Shibo, Wang, Ke, Chen, Jiachen, Jin, Feitong, Zhu, Xuhao, Zhu, Zitian, Shen, Fanhao, Wang, Ning, Zhang, Chuanyu, Wu, Yaozu, Zou, Yiren, Zhong, Jiarun, Cui, Zhengyi, Zhang, Aosai, Tan, Ziqi, Li, Tingting, Gao, Yu, Deng, Jinfeng, Zhang, Xu, Dong, Hang, Zhang, Pengfei, Jiang, Si, Li, Weikang, Lu, Zhide, Sun, Zheng-Zhi, Li, Hekang, Wang, Zhen, Song, Chao, Guo, Qiujiang, Liu, Fangli, Gong, Zhe-Xuan, Gorshkov, Alexey, Yao, Norman, Iadecola, Thomas, Machado, Francisco, Wang, H, and Deng, Dong-Ling

Abstract

Topologically ordered phases of matter elude Landaus symmetry-breaking theory, featuring a variety of intriguing properties such as long-range entanglement and intrinsic robustness against local perturbations. Their extension to periodically driven systems gives rise to exotic new phenomena that are forbidden in thermal equilibrium. Here, we report the observation of signatures of such a phenomenon-a prethermal topologically ordered time crystal-with programmable superconducting qubits arranged on a square lattice. By periodically driving the superconducting qubits with a surface code Hamiltonian, we observe discrete time-translation symmetry breaking dynamics that is only manifested in the subharmonic temporal response of nonlocal logical operators. We further connect the observed dynamics to the underlying topological order by measuring a nonzero topological entanglement entropy and studying its subsequent dynamics. Our results demonstrate the potential to explore exotic topologically ordered nonequilibrium phases of matter with noisy intermediate-scale quantum processors.

Published
2024

3. Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea.

Author

Chen, Mengting, Yang, Li, Zhou, Peijie, Jin, Suoqin, Wu, Zheng, Tan, Zixin, Xiao, Wenqin, Xu, San, Zhu, Yan, Wang, Mei, Jian, Dan, Liu, Fangfen, Tang, Yan, Zhao, Zhixiang, Huang, Yingxue, Shi, Wei, Xie, Hongfu, Nie, Qing, Wang, Ben, Deng, Zhili, and Li, Ji

Subjects
Rosacea, Sequence Analysis, RNA, Single-Cell Gene Expression Analysis, Fibroblasts, Keratinocytes, Schwann Cells, T-Lymphocytes, Humans, Male, Female, Young Adult, Adult, Middle Aged, Animals, Mice, Skin
Abstract

Rosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female rosacea patients and healthy individuals. Among keratinocytes, a subpopulation characterized by IFNγ-mediated barrier function damage is found to be unique to rosacea lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes and skin barrier damage in mice. The papulopustular rosacea is featured by expansion of pro-inflammatory fibroblasts, Schwann, endothelial and macrophage/dendritic cells. The frequencies of type 1/17 and skin-resident memory T cells are increased, and vascular mural cells are characterized by activation of inflammatory pathways and impaired muscle contraction function in rosacea. Most importantly, fibroblasts are identified as the leading cell type producing pro-inflammatory and vasodilative signals in rosacea. Depletion of fibroblasts or knockdown of PTGDS, a gene specifically upregulated in fibroblasts, blocks rosacea development in mice. Our study provides a comprehensive understanding of the aberrant alterations of skin-resident cell populations and identifies fibroblasts as a key determinant in rosacea development.

Published
2024

4. Unveiling the spin evolution in van der Waals antiferromagnets via magneto-exciton effects.

Author

Wang, Xingzhi, Tan, Qishuo, Li, Tie, Lu, Zhengguang, Cao, Jun, Ge, Yanan, Zhao, Lili, Tang, Jing, Kitadai, Hikari, Guo, Mingda, Li, Yun-Mei, Xu, Weigao, Cheng, Ran, Smirnov, Dmitry, and Ling, Xi

Abstract

Among the fascinating phenomena observed in two-dimensional (2D) magnets, the magneto-exciton effect stands out as a pivotal link between optics and magnetism. Although the excitonic effect has been revealed and exhibits a considerable correlation with the spin structures in certain 2D magnets, the underlying mechanism of the magneto-exciton effect remains underexplored, especially under high magnetic fields. Here we perform a systematic investigation of the spin-exciton coupling in 2D antiferromagnetic NiPS3 under high magnetic fields. When an in-plane magnetic field is applied, the exceptional sharp excitonic emission at ~1.4756 eV exhibits a Zeeman-like splitting with g ≈ 2.0, experimentally identifying the exciton as an excitation of dominant triplet-singlet character. By examining the polarization of excitonic emission and simulating the spin evolution, we further verify the correlation between excitonic emission and Néel vector in NiPS3. Our work elucidates the mechanism behind the spin-exciton coupling in NiPS3 and establishes a strategy for optically probing the spin evolutions in 2D magnets.

Published
2024

5. Catalytic undirected methylation of unactivated C(sp3)−H bonds suitable for complex molecules

Author

Tan, Jin-Fay, Kang, Yi Cheng, and Hartwig, John F

Subjects
Inorganic Chemistry, Organic Chemistry, Chemical Sciences, 5.1 Pharmaceuticals, Methylation, Catalysis, Nickel, Peroxides, Drug Discovery, Biological Products, Ligands, Terpenes, Peptides, Carbon
Abstract

In pharmaceutical discovery, the "magic methyl" effect describes a substantial improvement in the pharmacological properties of a drug candidate with the incorporation of methyl groups. Therefore, to expedite the synthesis of methylated drug analogs, late-stage, undirected methylations of C(sp3)-H bonds in complex molecules would be valuable. However, current methods for site-selective methylations are limited to activated C(sp3)-H bonds. Here we describe a site-selective, undirected methylation of unactivated C(sp3)-H bonds, enabled by photochemically activated peroxides and a nickel(II) complex whose turnover is enhanced by an ancillary ligand. The methodology displays compatibility with a wide range of functional groups and a high selectivity for tertiary C-H bonds, making it suitable for the late-stage methylation of complex organic compounds that contain multiple alkyl C-H bonds, such as terpene natural products, peptides, and active pharmaceutical ingredients. Overall, this method provides a synthetic tool to explore the "magic methyl" effect in drug discovery.

Published
2024

6. Coordination of transcription-coupled repair and repair-independent release of lesion-stalled RNA polymerase II.

Author

Zhu, Yongchang, Zhang, Xiping, Gao, Meng, Huang, Yanchao, Tan, Yuanqing, Parnas, Avital, Wu, Sizhong, Zhan, Delin, Adar, Sheera, and Hu, Jinchuan

Subjects
RNA Polymerase II, Humans, DNA Repair, Ubiquitination, Transcription, Genetic, DNA Damage, Ubiquitin-Specific Peptidase 7, Valosin Containing Protein, Proteasome Endopeptidase Complex, Excision Repair
Abstract

Transcription-blocking lesions (TBLs) stall elongating RNA polymerase II (Pol II), which then initiates transcription-coupled repair (TCR) to remove TBLs and allow transcription recovery. In the absence of TCR, eviction of lesion-stalled Pol II is required for alternative pathways to address the damage, but the mechanism is unclear. Using Protein-Associated DNA Damage Sequencing (PADD-seq), this study reveals that the p97-proteasome pathway can evict lesion-stalled Pol II independently of repair. Both TCR and repair-independent eviction require CSA and ubiquitination. However, p97 is dispensable for TCR and Pol II eviction in TCR-proficient cells, highlighting repairs prioritization over repair-independent eviction. Moreover, ubiquitination of RPB1-K1268 is important for both pathways, with USP7s deubiquitinase activity promoting TCR without abolishing repair-independent Pol II release. In summary, this study elucidates the fate of lesion-stalled Pol II, and may shed light on the molecular basis of genetic diseases caused by the defects of TCR genes.

Published
2024

7. Role of land-ocean interactions in stepwise Northern Hemisphere Glaciation.

Author

Zhong, Yi, Tan, Ning, Abell, Jordan, Sun, Chijun, Kaboth-Bahr, Stefanie, Ford, Heather, Herbert, Timothy, Pullen, Alex, Horikawa, Keiji, Yu, Jimin, Struve, Torben, Weber, Michael, Clift, Peter, Larrasoaña, Juan, Lu, Zhengyao, Yang, Hu, Bahr, André, Chen, Tianyu, Zhang, Jingyu, Wei, Cao, Xia, Wenyue, Yang, Sheng, and Liu, Qingsong

Abstract

The investigation of triggers causing the onset and intensification of Northern Hemisphere Glaciation (NHG) during the late Pliocene is essential for understanding the global climate system, with important implications for projecting future climate changes. Despite their critical roles in the global climate system, influences of land-ocean interactions on high-latitude ice sheets remain largely unexplored. Here, we present a high-resolution Asian dust record from Ocean Drilling Program Site 1208 in the North Pacific, which lies along the main route of the westerlies. Our data indicate that atmosphere-land-ocean interactions affected aeolian dust emissions through modulating moisture and vegetation in dust source regions, highlighting a critical role of terrestrial systems in initiating the NHG as early as 3.6 Myr ago. Combined with additional multi-proxy and model results, we further show that westerly wind strength was enhanced, mainly at low-to-middle tropospheric levels, during major glacial events at about 3.3 and 2.7 Myr ago. We suggest that coupled responses of Earths surface dynamics and atmospheric circulation in the Plio-Pleistocene likely involved feedbacks related to changes in paleogeography, ocean circulation, and global climate.

Published
2024

9. A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes

Author

Tan, Joanna Hui Juan, Li, Zhihui, Porta, Mar Gonzalez, Rajaby, Ramesh, Lim, Weng Khong, Tan, Ye An, Jimenez, Rodrigo Toro, Teo, Renyi, Hebrard, Maxime, Ow, Jack Ling, Ang, Shimin, Jeyakani, Justin, Chong, Yap Seng, Lim, Tock Han, Goh, Liuh Ling, Tham, Yih Chung, Leong, Khai Pang, Chin, Calvin Woon Loong, Davila, Sonia, Karnani, Neerja, Cheng, Ching-Yu, Chambers, John, Tai, E. Shyong, Liu, Jianjun, Sim, Xueling, Sung, Wing Kin, Prabhakar, Shyam, Tan, Patrick, and Bertin, Nicolas

Published
2024
Full Text
View/download PDF

10. Ductal lavage followed by observation versus oral corticosteroids in idiopathic granulomatous mastitis: A randomized trial

Author

Chen, Xiaolin, Huang, Heng, Huang, Hui, Yong, Juanjuan, Zhu, Liling, Chen, Qianru, Tan, Luyuan, Zeng, Yinduo, Yang, Yaping, Zhao, Jianli, Rao, Nanyan, Ding, Linxiaoxiao, Wu, Wenjing, Li, Yudong, Gui, Xiujuan, Ye, Liming, Xu, Yanlian, Jiang, Yumei, Su, Linhong, Xiao, Qiaozhen, Cai, Xueying, Hu, Tingting, Tan, Cui, Liu, Qiongmei, Liu, Shuyi, Zhao, Jinghua, Wang, Ying, Yu, Fengyan, Zhang, Jian, Li, Shunrong, and Chen, Kai

Published
2024
Full Text
View/download PDF

16. Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

Author

Lin, Quy Xiao Xuan, Rajagopalan, Deepa, Gamage, Akshamal M., Tan, Le Min, Venkatesh, Prasanna Nori, Chan, Wharton O. Y., Kumar, Dilip, Agrawal, Ragini, Chen, Yao, Fong, Siew-Wai, Singh, Amit, Sun, Louisa J., Tan, Seow-Yen, Chai, Louis Yi Ann, Somani, Jyoti, Lee, Bernett, Renia, Laurent, Ng, Lisa F P, Ramanathan, Kollengode, Wang, Lin-Fa, Young, Barnaby, Lye, David, Singhal, Amit, and Prabhakar, Shyam

Published
2024
Full Text
View/download PDF

17. Overcoming resolution attenuation during tilted cryo-EM data collection

Author

Aiyer, Sriram, Baldwin, Philip R., Tan, Shi Min, Shan, Zelin, Oh, Juntaek, Mehrani, Atousa, Bowman, Marianne E., Louie, Gordon, Passos, Dario Oliveira, Đorđević-Marquardt, Selena, Mietzsch, Mario, Hull, Joshua A., Hoshika, Shuichi, Barad, Benjamin A., Grotjahn, Danielle A., McKenna, Robert, Agbandje-McKenna, Mavis, Benner, Steven A., Noel, Joseph A. P., Wang, Dong, Tan, Yong Zi, and Lyumkis, Dmitry

Published
2024
Full Text
View/download PDF

19. A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming.

Author

Lin, Audrie, Fernald, Lia, Kim, Lisa, Yan, Liying, Meyer, Ann, Karim, Md, Shahriar, Sunny, Shuman, Gabrielle, Famida, Syeda, Akther, Salma, Hossen, Md, Mutsuddi, Palash, Shoab, Abul, Shalev, Idan, Rahman, Mahbubur, Unicomb, Leanne, Heaney, Christopher, Kariger, Patricia, Rahman, Md, Tan, Sophia, Ilyasova, Dora, Spasojevic, Ivan, Ali, Shahjahan, Luby, Stephen, Colford, John, Hubbard, Alan, Stewart, Christine, Granger, Douglas, Arnold, Benjamin, and Mertens, Andrew

Subjects
Humans, Hand Disinfection, Female, Sanitation, Bangladesh, Male, DNA Methylation, Infant, Epigenesis, Genetic, Child, Preschool, Pregnancy, Oxidative Stress, Stress, Physiological, Rural Population, Adult, Diarrhea, Receptors, Glucocorticoid
Abstract

A regulated stress response is essential for healthy child growth and development trajectories. We conducted a cluster-randomized trial in rural Bangladesh (funded by the Bill & Melinda Gates Foundation, ClinicalTrials.gov NCT01590095) to assess the effects of an integrated nutritional, water, sanitation, and handwashing intervention on child health. We previously reported on the primary outcomes of the trial, linear growth and caregiver-reported diarrhea. Here, we assessed additional prespecified outcomes: physiological stress response, oxidative stress, and DNA methylation (N = 759, ages 1-2 years). Eight neighboring pregnant women were grouped into a study cluster. Eight geographically adjacent clusters were block-randomized into the control or the combined nutrition, water, sanitation, and handwashing (N + WSH) intervention group (receiving nutritional counseling and lipid-based nutrient supplements, chlorinated drinking water, upgraded sanitation, and handwashing with soap). Participants and data collectors were not masked, but analyses were masked. There were 358 children (68 clusters) in the control group and 401 children (63 clusters) in the intervention group. We measured four F2-isoprostanes isomers (iPF(2α)-III; 2,3-dinor-iPF(2α)-III; iPF(2α)-VI; 8,12-iso-iPF(2α)-VI), salivary alpha-amylase and cortisol, and methylation of the glucocorticoid receptor (NR3C1) exon 1F promoter including the NGFI-A binding site. Compared with control, the N + WSH group had lower concentrations of F2-isoprostanes isomers (differences ranging from -0.16 to -0.19 log ng/mg of creatinine, P

Published
2024

20. Overcoming low initial coulombic efficiencies of Si anodes through prelithiation in all-solid-state batteries.

Author

Ham, So-Yeon, Sebti, Elias, Cronk, Ashley, Pennebaker, Tyler, Deysher, Grayson, Chen, Yu-Ting, Oh, Jin, Lee, Jeong, Song, Min, Ridley, Phillip, Tan, Darren, Clément, Raphaële, Jang, Jihyun, and Meng, Ying

Abstract

All-solid-state batteries using Si as the anode have shown promising performance without continual solid-electrolyte interface (SEI) growth. However, the first cycle irreversible capacity loss yields low initial Coulombic efficiency (ICE) of Si, limiting the energy density. To address this, we adopt a prelithiation strategy to increase ICE and conductivity of all-solid-state Si cells. A significant increase in ICE is observed for Li1Si anode paired with a lithium cobalt oxide (LCO) cathode. Additionally, a comparison with lithium nickel manganese cobalt oxide (NCM) reveals that performance improvements with Si prelithiation is only applicable for full cells dominated by high anode irreversibility. With this prelithiation strategy, 15% improvement in capacity retention is achieved after 1000 cycles compared to a pure Si. With Li1Si, a high areal capacity of up to 10 mAh cm-2 is attained using a dry-processed LCO cathode film, suggesting that the prelithiation method may be suitable for high-loading next-generation all-solid-state batteries.

Published
2024

21. Strain regulates the photovoltaic performance of thick-film perovskites.

Author

Shi, Pengju, Xu, Jiazhe, Yavuz, Ilhan, Huang, Tianyi, Tan, Shaun, Zhao, Ke, Zhang, Xu, Tian, Yuan, Wang, Sisi, Fan, Wei, Li, Yahui, Jin, Donger, Yu, Xuemeng, Wang, Chenyue, Gao, Xingyu, Chen, Zhong, Shi, Enzheng, Chen, Xihan, Yang, Deren, Xue, Jingjing, Wang, Rui, and Yang, Yang

Abstract

Perovskite photovoltaics, typically based on a solution-processed perovskite layer with a film thickness of a few hundred nanometres, have emerged as a leading thin-film photovoltaic technology. Nevertheless, many critical issues pose challenges to its commercialization progress, including industrial compatibility, stability, scalability and reliability. A thicker perovskite film on a scale of micrometres could mitigate these issues. However, the efficiencies of thick-film perovskite cells lag behind those with nanometre film thickness. With the mechanism remaining elusive, the community has long been under the impression that the limiting factor lies in the short carrier lifetime as a result of defects. Here, by constructing a perovskite system with extraordinarily long carrier lifetime, we rule out the restrictions of carrier lifetime on the device performance. Through this, we unveil the critical role of the ignored lattice strain in thick films. Our results provide insights into the factors limiting the performance of thick-film perovskite devices.

Published
2024

25. Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine

Author

Wang, Chaoyue, Kassem, Sari, Rocha, Rafael Eduardo Oliveira, Sun, Pei, Nguyen, Tan-Trung, Kloehn, Joachim, Liu, Xianyong, Brusini, Lorenzo, Bonavoglia, Alessandro, Barua, Sramona, Boissier, Fanny, Lucia Del Cistia, Mayara, Peng, Hongjuan, Tang, Xinming, Xie, Fujie, Wang, Zixuan, Vadas, Oscar, Suo, Xun, Hashem, Yaser, Soldati-Favre, Dominique, and Jia, Yonggen

Published
2024
Full Text
View/download PDF

29. Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years

Author

Neller, Michelle A., Ambalathingal, George R., Hamad, Nada, Sasadeusz, Joe, Pearson, Rebecca, Holmes-Liew, Chien-Li, Singhal, Deepak, Tunbridge, Matthew, Ng, Wei Yang, Sharplin, Kirsty, Moore, Andrew, Deambrosis, David, Soosay-Raj, Trisha, McNaughton, Peter, Whyte, Morag, Fraser, Chris, Grigg, Andrew, Kliman, David, Bajel, Ashish, Cummins, Katherine, Dowling, Mark, Yeoh, Zhi Han, Harrison, Simon J., Khot, Amit, Tan, Sarah, Roos, Izanne, Koo, Ray Mun, Dohrmann, Sara, Ritchie, David, Wainstein, Brynn, McCleary, Karen, Nelson, Adam, Gardiner, Bradley, Inam, Shafqat, Badoux, Xavier, Ma, Kris, Toro, Claudia, Hanna, Diane, Hughes, David, Conyers, Rachel, Cole, Theresa, Wang, Shiqi Stacie, Chee, Lynette, Fleming, Jacqueline, Irish, Ashley, Purtill, Duncan, Cooney, Julian, Shaw, Peter, Tey, Siok-Keen, Hunt, Stewart, Subramonia Pillai, Elango, John, George, Ng, Michelle, Ramachandran, Shanti, Hopkins, Peter, Chambers, Daniel, Campbell, Scott, Francis, Ross, Isbel, Nicole, Marlton, Paula, Reddiex, Hilary, Matthews, Katherine K., Voogt, Meggie, Panikkar, Archana, Beagley, Leone, Rehan, Sweera, Best, Shannon, Raju, Jyothy, Le Texier, Laetitia, Crooks, Pauline, Solomon, Matthew, Lekieffre, Lea, Srihari, Sriganesh, Smith, Corey, and Khanna, Rajiv

Published
2024
Full Text
View/download PDF

33. Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission

Author

Chen, Yang, Gu, Yuhao, Wang, Bianbian, Wei, Anqi, Dong, Nan, Jiang, Yong, Liu, Xiaoying, Zhu, Li, Zhu, Feng, Tan, Tao, Jing, Zexin, Mao, Fenghan, Zhang, Yichi, Yao, Jingyu, Yang, Yuxin, Wang, Hongyan, Wu, Hao, Li, Hua, Zheng, Chaowen, Duan, Xueting, Huo, Jingxiao, Wu, Xuanang, Hu, Shaoqin, Zhao, Anran, Li, Ziyang, Cheng, Xu, Qin, Yuhao, Song, Qian, Zhan, Shuqin, Qu, Qiumin, Guan, Fanglin, Xu, Huadong, Kang, Xinjiang, and Wang, Changhe

Published
2024
Full Text
View/download PDF

37. Emergence of steady quantum transport in a superconducting processor

Author

Zhang, Pengfei, Gao, Yu, Xu, Xiansong, Wang, Ning, Dong, Hang, Guo, Chu, Deng, Jinfeng, Zhang, Xu, Chen, Jiachen, Xu, Shibo, Wang, Ke, Wu, Yaozu, Zhang, Chuanyu, Jin, Feitong, Zhu, Xuhao, Zhang, Aosai, Zou, Yiren, Tan, Ziqi, Cui, Zhengyi, Zhu, Zitian, Shen, Fanhao, Li, Tingting, Zhong, Jiarun, Bao, Zehang, Zhao, Liangtian, Hao, Jie, Li, Hekang, Wang, Zhen, Song, Chao, Guo, Qiujiang, Wang, H., and Poletti, Dario

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results