1. The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
- Author
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Pan JW, Zabidi MMA, Ng PS, Meng MY, Hasan SN, Sandey B, Sammut SJ, Yip CH, Rajadurai P, Rueda OM, Caldas C, Chin SF, and Teo SH
- Subjects
- Breast Neoplasms immunology, Breast Neoplasms pathology, Female, Genome, Human, Humans, Mutation genetics, Receptor, ErbB-2 genetics, Receptor, ErbB-2 metabolism, Receptors, Estrogen metabolism, Survival Analysis, Tumor Microenvironment immunology, Tumor Suppressor Protein p53 genetics, White People genetics, Asian People genetics, Breast Neoplasms genetics, Genetics, Population
- Abstract
Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain understudied. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women. Compared to breast tumours in Caucasian women, we show an increased prevalence of HER2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumours. We also observe elevated immune scores in Asian breast tumours, suggesting potential clinical response to immune checkpoint inhibitors. Whilst HER2-subtype and enriched immune score are associated with improved survival, presence of TP53 somatic mutations is associated with poorer survival in ER+ tumours. Taken together, these population differences unveil opportunities to improve the understanding of this disease and lay the foundation for precision medicine in different populations.
- Published
- 2020
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