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Your search keyword '"Tijsterman, Marcel"' showing total 12 results
Start Over Author "Tijsterman, Marcel" Journal nature communications
12 results on '"Tijsterman, Marcel"'

4. Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51

Author

Heijink, Anne Margriet, Stok, Colin, Porubsky, David, Manolika, Eleni Maria, de Kanter, Jurrian K., Kok, Yannick P., Everts, Marieke, de Boer, H. Rudolf, Audrey, Anastasia, Bakker, Femke J., Wierenga, Elles, Tijsterman, Marcel, Guryev, Victor, Spierings, Diana C. J., Knipscheer, Puck, van Boxtel, Ruben, Ray Chaudhuri, Arnab, Lansdorp, Peter M., and van Vugt, Marcel A. T. M.

Published
2022
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6. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Author

Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., and Lord, Christopher J.

Published
2021
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12. [Untitled]

Author

van Schendel, Robin, Roerink, Sophie F, Portegijs, Vincent, van den Heuvel, Sander, Tijsterman, Marcel, Sub Developmental Biology, Dep Biologie, Developmental Biology, Sub Developmental Biology, Dep Biologie, and Developmental Biology

Subjects
DNA End-Joining Repair, DNA Repair, DNA repair, DNA polymerase II, General Physics and Astronomy, DNA-Directed DNA Polymerase, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, Homology directed repair, Animals, CRISPR, DNA Breaks, Double-Stranded, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Germ-Line Mutation, Polymerase, Genetics, Genome, Helminth, Multidisciplinary, General Chemistry, DNA repair protein XRCC4, Germ Cells, Mutagenesis, Mutation, biology.protein, CRISPR-Cas Systems, DNA polymerase mu, Nucleotide excision repair
Abstract

Cells are protected from toxic DNA double-stranded breaks (DSBs) by a number of DNA repair mechanisms, including some that are intrinsically error prone, thus resulting in mutations. To what extent these mechanisms contribute to evolutionary diversification remains unknown. Here, we demonstrate that the A-family polymerase theta (POLQ) is a major driver of inheritable genomic alterations in Caenorhabditis elegans. Unlike somatic cells, which use non-homologous end joining (NHEJ) to repair DNA transposon-induced DSBs, germ cells use polymerase theta-mediated end joining, a conceptually simple repair mechanism requiring only one nucleotide as a template for repair. Also CRISPR/Cas9-induced genomic changes are exclusively generated through polymerase theta-mediated end joining, refuting a previously assumed requirement for NHEJ in their formation. Finally, through whole-genome sequencing of propagated populations, we show that only POLQ-proficient animals accumulate genomic scars that are abundantly present in genomes of wild C. elegans, pointing towards POLQ as a major driver of genome diversification., DNA double-stranded breaks can be repaired through error-prone pathways. Here, van Schendel et al. demonstrate that C. elegans acquires inheritable mutations through the use of polymerase theta-mediated end joining.

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