1. Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
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Annette Juul Vangsted, van, Duin, M, David E. Neal, Peter Hoffmann, A Wolk, Robert J. Hamilton, Anthony J. Swerdlow, F. Wiklund, De, Ruyck, K, Paul A. Townsend, S. N. Thibodeau, Asta Försti, Esther M. John, Unnur Thorsteinsdottir, W Gregory, Niels Frost Andersen, Peter Broderick, A-K Wihlborg, Frank Claessens, Doug Easton, Kathryn L. Penney, Keith W. Muir, Jeri Kim, Jonathan S. Mitchell, Johanna Schleutker, G Cancel-Tassin, Barry S. Rosenstein, Jy Park, Hauke Thomsen, Rowan Kuiper, C West, H Gronberg, Mina Ali, CM Tangen, Obul Reddy Bandapalli, Ana Vega, Faith E. Davies, Rosalind A. Eeles, Daniel F. Gudbjartsson, Fredrick R. Schumacher, Janet L. Stanford, Paul D.P. Pharoah, Owen W. Stephens, Monique J. Roobol, Richard S. Houlston, Gudmar Thorleifsson, Christian Langer, Susan L. Neuhausen, S Chanock, G.G. Giles, Azad Razack, S Koutros, F Canzian, S Benlloch, H. Einsele, Kari Hemminki, KD Sorensen, Y-J Lu, K-T Khaw, Hareth Nahi, FC Hamdy, D Albanes, Christopher A. Haiman, Ellinor Johnsson, Amit Sud, Adam S. Kibel, Pieter Sonneveld, Florence Menegaux, Manolis Kogevinas, Nawaid Usmani, Annemiek Broyl, K. H. Jöckel, Jolanta Nickel, David W. Johnson, Aaa Olama, B.G. Nordestgaard, Amy Holroyd, Niels Weinhold, Cezary Cybulski, Sigurdur Y. Kristinsson, Radka Kaneva, Ruth C. Travis, Kari Stefansson, SI Berndt, Bowang Chen, Scott Kimber, Davor Lessel, Philip J. Law, M. M. Nöthen, Lisa A. Cannon-Albright, BE Henderson, Ni Li, Urban Gullberg, Uta Bertsch, S Weinstein, Nora Pashayan, Christiane Maier, H Brenner, Ingemar Turesson, Hardev Pandha, Thorunn Rafnar, Alison M. Dunning, Fiona M. Ross, Graham Jackson, David V. Conti, Sue A. Ingles, da, Silva, Filho, Mi, Jens Hillengass, Lisa F. Newcomb, Giulia Orlando, Brian A Walker, Teixeira, Björn Nilsson, Jenny L Donovan, Molly Went, U. H. Mellqvist, Chiara Campo, Zsofia Kote-Jarai, VL Stevens, Martin Kaiser, B-M Halvarsson, J Clements, Martin Hansson, Manuela Gago-Dominguez, EM Grindedal, Anders Waage, Julian Peto, L Mucci, Gareth J. Morgan, J Batra, and H. Goldschmidt
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Male ,Quality Control ,Risk ,0301 basic medicine ,Chromatin Immunoprecipitation ,Genotype ,Computer science ,Science ,Quantitative Trait Loci ,Medizin ,General Physics and Astronomy ,Genome-wide association study ,02 engineering and technology ,computer.software_genre ,Polymorphism, Single Nucleotide ,White People ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Humans ,Genetic Predisposition to Disease ,lcsh:Science ,Author Correction ,Promoter Regions, Genetic ,Multidisciplinary ,business.industry ,Bayes Theorem ,General Chemistry ,021001 nanoscience & nanotechnology ,Chromatin ,Spelling ,Identification (information) ,030104 developmental biology ,Gene Expression Regulation ,Cancer genetics ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,lcsh:Q ,Female ,Artificial intelligence ,Multiple Myeloma ,0210 nano-technology ,business ,computer ,Natural language processing ,Genome-Wide Association Study - Abstract
Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM.
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- 2019
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