28 results on '"Wang, Wang"'
Search Results
2. Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging
- Author
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Yulei Chang, Haoren Chen, Xiaoyu Xie, Yong Wan, Qiqing Li, Fengxia Wu, Run Yang, Wang Wang, and Xianggui Kong
- Subjects
Science - Abstract
Fluorescence imaging in the near-infrared region yields high-quality images that overcome the current depth limitations. Here, the authors report a Tm3 + -based nanoprobe for NIR-IIb/c imaging, providing references to future bioimaging beyond 1700 nm.
- Published
- 2023
- Full Text
- View/download PDF
3. Observation of an intermediate state during lithium intercalation of twisted bilayer MoS2
- Author
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Yecun Wu, Jingyang Wang, Yanbin Li, Jiawei Zhou, Bai Yang Wang, Ankun Yang, Lin-Wang Wang, Harold Y. Hwang, and Yi Cui
- Subjects
Science - Abstract
Li intercalation of MoS2 induces a transition from the insulating H-phase to the metallic T-phase, with a sharp boundary in between. Here the authors stabilize the intermediate phase in twisted bilayer MoS2, by leveraging the Moiré potential which facilitates fast Li diffusion and uniform intercalation.
- Published
- 2022
- Full Text
- View/download PDF
4. Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
- Author
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Tingting Li, Xiaojian Han, Chenjian Gu, Hangtian Guo, Huajun Zhang, Yingming Wang, Chao Hu, Kai Wang, Fengjiang Liu, Feiyang Luo, Yanan Zhang, Jie Hu, Wang Wang, Shenglong Li, Yanan Hao, Meiying Shen, Jingjing Huang, Yingyi Long, Shuyi Song, Ruixin Wu, Song Mu, Qian Chen, Fengxia Gao, Jianwei Wang, Shunhua Long, Luo Li, Yang Wu, Yan Gao, Wei Xu, Xia Cai, Di Qu, Zherui Zhang, Hongqing Zhang, Na Li, Qingzhu Gao, Guiji Zhang, Changlong He, Wei Wang, Xiaoyun Ji, Ni Tang, Zhenghong Yuan, Youhua Xie, Haitao Yang, Bo Zhang, Ailong Huang, and Aishun Jin
- Subjects
Science - Abstract
Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.
- Published
- 2021
- Full Text
- View/download PDF
5. Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
- Author
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Jia-Wang Wang, Yan Li, Wan Nie, Zhe Chang, Zi-An Yu, Yi-Fan Zhao, Xi Lu, and Yao Fu
- Subjects
Science - Abstract
Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives.
- Published
- 2021
- Full Text
- View/download PDF
6. Electrotunable liquid sulfur microdroplets
- Author
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Guangmin Zhou, Ankun Yang, Yifei Wang, Guoping Gao, Allen Pei, Xiaoyun Yu, Yangying Zhu, Linqi Zong, Bofei Liu, Jinwei Xu, Nian Liu, Jinsong Zhang, Yanxi Li, Lin-Wang Wang, Harold Y. Hwang, Mark L. Brongersma, Steven Chu, and Yi Cui
- Subjects
Science - Abstract
Manipulating liquids with tunable shape and optical functionalities in real time remains a great challenge. Here, the authors demonstrate electrotunable liquid sulfur microdroplets in an electrochemical cell and tune its characteristics in a fast, repeatable, and controlled manner.
- Published
- 2020
- Full Text
- View/download PDF
7. Reaction scope and mechanistic insights of nickel-catalyzed migratory Suzuki–Miyaura cross-coupling
- Author
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Yuqiang Li, Yixin Luo, Long Peng, Yangyang Li, Binzhi Zhao, Wang Wang, Hailiang Pang, Yi Deng, Ruopeng Bai, Yu Lan, and Guoyin Yin
- Subjects
Science - Abstract
Migratory cross-coupling reactions are powerful tools to form bonds at predictable positions. Here the authors report a nickel-catalyzed migratory Suzuki–Miyaura cross-coupling of unactivated alkyl electrophiles with aryl and vinyl boron reagents and provide experimental and computational mechanistic evidence.
- Published
- 2020
- Full Text
- View/download PDF
8. Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
- Author
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Li, Tingting, Han, Xiaojian, Gu, Chenjian, Guo, Hangtian, Zhang, Huajun, Wang, Yingming, Hu, Chao, Wang, Kai, Liu, Fengjiang, Luo, Feiyang, Zhang, Yanan, Hu, Jie, Wang, Wang, Li, Shenglong, Hao, Yanan, Shen, Meiying, Huang, Jingjing, Long, Yingyi, Song, Shuyi, Wu, Ruixin, Mu, Song, Chen, Qian, Gao, Fengxia, Wang, Jianwei, Long, Shunhua, Li, Luo, Wu, Yang, Gao, Yan, Xu, Wei, Cai, Xia, Qu, Di, Zhang, Zherui, Zhang, Hongqing, Li, Na, Gao, Qingzhu, Zhang, Guiji, He, Changlong, Wang, Wei, Ji, Xiaoyun, Tang, Ni, Yuan, Zhenghong, Xie, Youhua, Yang, Haitao, Zhang, Bo, Huang, Ailong, and Jin, Aishun
- Published
- 2021
- Full Text
- View/download PDF
9. Engineering Auger recombination in colloidal quantum dots via dielectric screening
- Author
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Xiaoqi Hou, Jun Kang, Haiyan Qin, Xuewen Chen, Junliang Ma, Jianhai Zhou, Liping Chen, Linjun Wang, Lin-Wang Wang, and Xiaogang Peng
- Subjects
Science - Abstract
Designing core/shell quantum dots with desired optoelectronic properties remains a challenge. Here, the authors investigate the negative and positive trions dynamics within a quantum dot, proposing an Auger engineering strategy based on geometry-dependent dielectrics for tuning optical properties.
- Published
- 2019
- Full Text
- View/download PDF
10. Complex strain evolution of polar and magnetic order in multiferroic BiFeO3 thin films
- Author
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Zuhuang Chen, Zhanghui Chen, Chang-Yang Kuo, Yunlong Tang, Liv R. Dedon, Qian Li, Lei Zhang, Christoph Klewe, Yen-Lin Huang, Bhagwati Prasad, Alan Farhan, Mengmeng Yang, James D. Clarkson, Sujit Das, Sasikanth Manipatruni, A. Tanaka, Padraic Shafer, Elke Arenholz, Andreas Scholl, Ying-Hao Chu, Z. Q. Qiu, Zhiwei Hu, Liu-Hao Tjeng, Ramamoorthy Ramesh, Lin-Wang Wang, and Lane W. Martin
- Subjects
Science - Abstract
To fully exploit the potential of multiferroic materials the control of their intrinsic degrees of freedom is a prerequisite. Here, the control of spin orientation in strained BiFeO3 films is demonstrated elucidating the microscopic mechanism of the complex interplay of polar and magnetic order.
- Published
- 2018
- Full Text
- View/download PDF
11. Reaction scope and mechanistic insights of nickel-catalyzed migratory Suzuki–Miyaura cross-coupling
- Author
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Li, Yuqiang, Luo, Yixin, Peng, Long, Li, Yangyang, Zhao, Binzhi, Wang, Wang, Pang, Hailiang, Deng, Yi, Bai, Ruopeng, Lan, Yu, and Yin, Guoyin
- Published
- 2020
- Full Text
- View/download PDF
12. Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
- Author
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Yelin Wu, Yanchun Quan, Yuanqi Liu, Keiwei Liu, Hongquan Li, Ziwei Jiang, Tian Zhang, Hu Lei, Katherine A. Radek, Dongqing Li, Zhenhua Wang, Jilong Lu, Wang Wang, Shizhao Ji, Zhaofan Xia, and Yuping Lai
- Subjects
Science - Abstract
Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.
- Published
- 2016
- Full Text
- View/download PDF
13. CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
- Author
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Shangcheng Xu, Pei Wang, Huiliang Zhang, Guohua Gong, Nicolas Gutierrez Cortes, Weizhong Zhu, Yisang Yoon, Rong Tian, and Wang Wang
- Subjects
Science - Abstract
β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.
- Published
- 2016
- Full Text
- View/download PDF
14. Author Correction: Engineering Auger recombination in colloidal quantum dots via dielectric screening
- Author
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Xiaoqi Hou, Jun Kang, Haiyan Qin, Xuewen Chen, Junliang Ma, Jianhai Zhou, Liping Chen, Linjun Wang, Lin-Wang Wang, and Xiaogang Peng
- Subjects
Science - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2019
- Full Text
- View/download PDF
15. Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging.
- Author
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Chang, Yulei, Chen, Haoren, Xie, Xiaoyu, Wan, Yong, Li, Qiqing, Wu, Fengxia, Yang, Run, Wang, Wang, and Kong, Xianggui
- Subjects
LUMINESCENCE ,STOKES shift ,PHOTOTHERMAL effect ,INTRAMOLECULAR proton transfer reactions ,PHOTONS ,THULIUM ,NEAR infrared radiation ,FLUORESCENCE - Abstract
Fluorescence bioimaging based on rare-earth-doped nanocrystals (RENCs) in the shortwave infrared (SWIR, 1000–3000 nm) region has aroused intense interest due to deeper penetration depth and clarity. However, their downshifting emission rarely shows sufficient brightness beyond 1600 nm, especially in NIR-IIc. Here, we present a class of thulium (Tm) self-sensitized RENC fluorescence probes that exhibit bright downshifting luminescence at 1600–2100 nm (NIR-IIb/c) for in vivo bioimaging. An inert shell coating minimizes surface quenching and combines strong cross-relaxation, allowing LiTmF
4 @LiYF4 NPs to emit these intense downshifting emissions by absorbing NIR photons at 800 nm (large Stokes shift ~1000 nm with a absolute quantum yield of ~14.16%) or 1208 nm (NIR-IIin and NIR-IIout ). Furthermore, doping with Er3+ for energy trapping achieves four-wavelength NIR irradiation and bright NIR-IIb/c emission. Our results show that Tm-based NPs, as NIR-IIb/c nanoprobes with high signal-to-background ratio and clarity, open new opportunities for future applications and translation into diverse fields. Fluorescence imaging in the near-infrared region yields high-quality images that overcome the current depth limitations. Here, the authors report a Tm3 + -based nanoprobe for NIR-IIb/c imaging, providing references to future bioimaging beyond 1700 nm. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
16. Electrotunable liquid sulfur microdroplets
- Author
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Guoping Gao, Yanxi Li, Mark L. Brongersma, Allen Pei, Bofei Liu, Yifei Wang, Jinwei Xu, Xiaoyun Yu, Linqi Zong, Jinsong Zhang, Lin-Wang Wang, Ankun Yang, Harold Y. Hwang, Yangying Zhu, Steven Chu, Guangmin Zhou, Nian Liu, and Yi Cui
- Subjects
Battery (electricity) ,Materials science ,Science ,General Physics and Astronomy ,chemistry.chemical_element ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,Electrochemical cell ,Electrochemistry ,Optical materials and structures ,lcsh:Science ,Microlens ,Multidisciplinary ,General Chemistry ,021001 nanoscience & nanotechnology ,Sulfur ,0104 chemical sciences ,chemistry ,Electrowetting ,Materials chemistry ,lcsh:Q ,0210 nano-technology - Abstract
Manipulating liquids with tunable shape and optical functionalities in real time is important for electroactive flow devices and optoelectronic devices, but remains a great challenge. Here, we demonstrate electrotunable liquid sulfur microdroplets in an electrochemical cell. We observe electrowetting and merging of sulfur droplets under different potentiostatic conditions, and successfully control these processes via selective design of sulfiphilic/sulfiphobic substrates. Moreover, we employ the electrowetting phenomena to create a microlens based on the liquid sulfur microdroplets and tune its characteristics in real time through changing the shape of the liquid microdroplets in a fast, repeatable, and controlled manner. These studies demonstrate a powerful in situ optical battery platform for unraveling the complex reaction mechanism of sulfur chemistries and for exploring the rich material properties of the liquid sulfur, which shed light on the applications of liquid sulfur droplets in devices such as microlenses, and potentially other electrotunable and optoelectronic devices., Manipulating liquids with tunable shape and optical functionalities in real time remains a great challenge. Here, the authors demonstrate electrotunable liquid sulfur microdroplets in an electrochemical cell and tune its characteristics in a fast, repeatable, and controlled manner.
- Published
- 2020
17. Reaction scope and mechanistic insights of nickel-catalyzed migratory Suzuki–Miyaura cross-coupling
- Author
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Yixin Luo, Long Peng, Yangyang Li, Yi Deng, Hailiang Pang, Binzhi Zhao, Wang Wang, Guoyin Yin, Ruopeng Bai, Yu Lan, and Yuqiang Li
- Subjects
inorganic chemicals ,Allylic rearrangement ,Catalyst synthesis ,Reaction mechanisms ,Science ,General Physics and Astronomy ,010402 general chemistry ,01 natural sciences ,Article ,General Biochemistry, Genetics and Molecular Biology ,Catalysis ,chemistry.chemical_compound ,lcsh:Science ,Alkyl ,chemistry.chemical_classification ,Multidisciplinary ,Catalytic mechanisms ,010405 organic chemistry ,Chemistry ,Ligand ,Aryl ,Cationic polymerization ,food and beverages ,General Chemistry ,Homogeneous catalysis ,Combinatorial chemistry ,0104 chemical sciences ,Catalytic cycle ,Electrophile ,Density functional theory ,lcsh:Q - Abstract
Cross-coupling reactions have developed into powerful approaches for carbon–carbon bond formation. In this work, a Ni-catalyzed migratory Suzuki–Miyaura cross-coupling featuring high benzylic or allylic selectivity has been developed. With this method, unactivated alkyl electrophiles and aryl or vinyl boronic acids can be efficiently transferred to diarylalkane or allylbenzene derivatives under mild conditions. Importantly, unactivated alkyl chlorides can also be successfully used as the coupling partners. To demonstrate the applicability of this method, we showcase that this strategy can serve as a platform for the synthesis of terminal, partially deuterium-labeled molecules from readily accessible starting materials. Experimental studies suggest that migratory cross-coupling products are generated from Ni(0/II) catalytic cycle. Theoretical calculations indicate that the chain-walking occurs at a neutral nickel complex rather than a cationic one. In addition, the original-site cross-coupling products can be obtained by alternating the ligand, wherein the formation of the products has been rationalized by a radical chain process., Migratory cross-coupling reactions are powerful tools to form bonds at predictable positions. Here the authors report a nickel-catalyzed migratory Suzuki–Miyaura cross-coupling of unactivated alkyl electrophiles with aryl and vinyl boron reagents and provide experimental and computational mechanistic evidence.
- Published
- 2020
18. Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
- Author
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Kai Wang, Xiaojian Han, Zhe-Rui Zhang, Ailong Huang, Shuyi Song, Jie Hu, Guiji Zhang, Yan Gao, Chenjian Gu, Hong-Qing Zhang, Aishun Jin, Changlong He, Bo Zhang, Ruixin Wu, Chao Hu, Luo Li, Qian Chen, Shenglong Li, Ya-Nan Zhang, Shunhua Long, Wang Wang, Fengxia Gao, Jingjing Huang, Tingting Li, Xia Cai, Wei Xu, Na Li, Song Mu, Meiying Shen, Feiyang Luo, Wang Wei, Yanan Hao, Ni Tang, Yang Wu, Haitao Yang, Jianwei Wang, Youhua Xie, Huajun Zhang, Zhenghong Yuan, Di Qu, Fengjiang Liu, Yingming Wang, Yingyi Long, Qingzhu Gao, Hangtian Guo, and Xiaoyun Ji
- Subjects
medicine.drug_class ,viruses ,Science ,Mutant ,General Physics and Astronomy ,Mice, Transgenic ,Antibodies, Viral ,medicine.disease_cause ,Monoclonal antibody ,Article ,Antibodies ,General Biochemistry, Genetics and Molecular Biology ,Epitope ,Virus ,Epitopes ,Mice ,Weight Loss ,medicine ,Animals ,Humans ,Potency ,Binding site ,Mutation ,Binding Sites ,Multidisciplinary ,biology ,SARS-CoV-2 ,Antibodies, Monoclonal ,COVID-19 ,General Chemistry ,Viral Load ,Antibodies, Neutralizing ,Virology ,Spike Glycoprotein, Coronavirus ,biology.protein ,Antibody - Abstract
Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5 and 13G9, with high neutralizing potency blocking authentic SARS-CoV-2 virus display remarkable efficacy against authentic B.1.351 virus. Surprisingly, structural analysis has revealed that 58G6 and 13G9 both recognize the steric region S470–495 on the RBD, overlapping the E484K mutation presented in B.1.351. Also, 58G6 directly binds to another region S450–458 in the RBD. Significantly, 58G6 and 510A5 both demonstrate prophylactic efficacy against authentic SARS-CoV-2 and B.1.351 viruses in the transgenic mice expressing human ACE2 (hACE2), protecting weight loss and reducing virus loads. Together, we have evidenced 2 potent neutralizing Abs with unique mechanism targeting authentic SARS-CoV-2 mutants, which can be promising candidates to fulfill the urgent needs for the prolonged COVID-19 pandemic., Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.
- Published
- 2021
19. Observation of an intermediate state during lithium intercalation of twisted bilayer MoS
- Author
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Yecun, Wu, Jingyang, Wang, Yanbin, Li, Jiawei, Zhou, Bai Yang, Wang, Ankun, Yang, Lin-Wang, Wang, Harold Y, Hwang, and Yi, Cui
- Abstract
Lithium intercalation of MoS
- Published
- 2021
20. Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
- Author
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Zi An Yu, Yao Fu, Jia-Wang Wang, Yi Fan Zhao, Zhe Chang, Wan Nie, Xi Lu, and Yan Li
- Subjects
inorganic chemicals ,Science ,Reaction mechanisms ,General Physics and Astronomy ,Synthetic chemistry methodology ,Alkylation ,010402 general chemistry ,01 natural sciences ,Article ,General Biochemistry, Genetics and Molecular Biology ,Catalysis ,chemistry.chemical_compound ,Asymmetric catalysis ,Alkyl ,Amination ,chemistry.chemical_classification ,Multidisciplinary ,010405 organic chemistry ,organic chemicals ,Aryl ,General Chemistry ,Combinatorial chemistry ,0104 chemical sciences ,Enantiopure drug ,chemistry ,Asymmetric carbon ,Electrophile - Abstract
To increase the reliability and success rate of drug discovery, efforts have been made to increase the C(sp3) fraction and avoid flat molecules. sp3-Rich enantiopure amines are most frequently encountered as chiral auxiliaries, synthetic intermediates for pharmaceutical agents and bioactive natural products. Streamlined construction of chiral aliphatic amines has long been regarded as a paramount challenge. Mainstream approaches, including hydrogenation of enamines and imines, C–H amination, and alkylation of imines, were applied for the synthesis of chiral amines with circumscribed skeleton structures; typically, the chiral carbon centre was adjacent to an auxiliary aryl or ester group. Herein, we report a mild and general nickel-catalysed asymmetric reductive hydroalkylation to effectively convert enamides and enecarbamates into drug-like α-branched chiral amines and derivatives. This reaction involves the regio- and stereoselective hydrometallation of an enamide or enecarbamate to generate a catalytic amount of enantioenriched alkylnickel intermediate, followed by C–C bond formation via alkyl electrophiles., Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives.
- Published
- 2021
21. Engineering Auger recombination in colloidal quantum dots via dielectric screening
- Author
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Xiaogang Peng, Junliang Ma, Jun Kang, Xue-Wen Chen, Jianhai Zhou, Haiyan Qin, Xiaoqi Hou, Linjun Wang, Liping Chen, and Lin-Wang Wang
- Subjects
0301 basic medicine ,Materials science ,Science ,General Physics and Astronomy ,Physics::Optics ,02 engineering and technology ,Dielectric ,Molecular physics ,Article ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Auger ,03 medical and health sciences ,symbols.namesake ,Condensed Matter::Materials Science ,law ,MD Multidisciplinary ,lcsh:Science ,Author Correction ,Quantum ,Multidisciplinary ,Auger effect ,Quantum dots ,General Chemistry ,021001 nanoscience & nanotechnology ,Laser ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,030104 developmental biology ,Quantum dot ,Optical materials ,symbols ,lcsh:Q ,Trion ,0210 nano-technology ,Order of magnitude ,Biotechnology - Abstract
Auger recombination is the main non-radiative decay pathway for multi-carrier states of colloidal quantum dots, which affects performance of most of their optical and optoelectronic applications. Outstanding single-exciton properties of CdSe/CdS core/shell quantum dots enable us to simultaneously study the two basic types of Auger recombination channels—negative trion and positive trion channels. Though Auger rates of positive trion are regarded to be much faster than that of negative trion for II-VI quantum dots in literature, our experiments find the two rates can be inverted for certain core/shell geometries. This is confirmed by theoretical calculations as a result of geometry-dependent dielectric screening. By varying the core/shell geometry, both types of Auger rates can be independently tuned for ~ 1 order of magnitude. Experimental and theoretical findings shed new light on designing quantum dots with necessary Auger recombination characteristics for high-power light-emitting-diodes, lasers, single-molecular tracking, super-resolution microscope, and advanced quantum light sources., Designing core/shell quantum dots with desired optoelectronic properties remains a challenge. Here, the authors investigate the negative and positive trions dynamics within a quantum dot, proposing an Auger engineering strategy based on geometry-dependent dielectrics for tuning optical properties.
- Published
- 2018
22. Complex strain evolution of polar and magnetic order in multiferroic BiFeO
- Author
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Zuhuang, Chen, Zhanghui, Chen, Chang-Yang, Kuo, Yunlong, Tang, Liv R, Dedon, Qian, Li, Lei, Zhang, Christoph, Klewe, Yen-Lin, Huang, Bhagwati, Prasad, Alan, Farhan, Mengmeng, Yang, James D, Clarkson, Sujit, Das, Sasikanth, Manipatruni, A, Tanaka, Padraic, Shafer, Elke, Arenholz, Andreas, Scholl, Ying-Hao, Chu, Z Q, Qiu, Zhiwei, Hu, Liu-Hao, Tjeng, Ramamoorthy, Ramesh, Lin-Wang, Wang, and Lane W, Martin
- Abstract
Electric-field control of magnetism requires deterministic control of the magnetic order and understanding of the magnetoelectric coupling in multiferroics like BiFeO
- Published
- 2017
23. Author Correction: Engineering Auger recombination in colloidal quantum dots via dielectric screening
- Author
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Jianhai Zhou, Xiaogang Peng, Linjun Wang, Junliang Ma, Jun Kang, Xue-Wen Chen, Xiaoqi Hou, Liping Chen, Haiyan Qin, and Lin-Wang Wang
- Subjects
Multidisciplinary ,Materials science ,Auger effect ,business.industry ,Science ,General Physics and Astronomy ,General Chemistry ,Dielectric ,General Biochemistry, Genetics and Molecular Biology ,symbols.namesake ,MD Multidisciplinary ,symbols ,Optoelectronics ,lcsh:Q ,Colloidal quantum dots ,business ,lcsh:Science - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2019
24. CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
- Author
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Rong Tian, Pei Wang, Wang Wang, Yisang Yoon, Huiliang Zhang, Shangcheng Xu, Nicolas Gutierrez Cortes, Weizhong Zhu, and Guohua Gong
- Subjects
0301 basic medicine ,Dynamins ,Male ,endocrine system ,animal diseases ,Science ,General Physics and Astronomy ,Stimulation ,Mice, Transgenic ,Mitochondrion ,environment and public health ,Mitochondrial Membrane Transport Proteins ,General Biochemistry, Genetics and Molecular Biology ,Article ,Cell Line ,Rats, Sprague-Dawley ,03 medical and health sciences ,Mitochondrial membrane transport protein ,chemistry.chemical_compound ,Ca2+/calmodulin-dependent protein kinase ,Receptors, Adrenergic, beta ,Animals ,Myocytes, Cardiac ,Phosphorylation ,Cells, Cultured ,Mice, Knockout ,Multidisciplinary ,biology ,Mitochondrial Permeability Transition Pore ,MPTP ,Isoproterenol ,General Chemistry ,Adrenergic beta-Agonists ,nervous system diseases ,Cell biology ,Mitochondria ,Mice, Inbred C57BL ,030104 developmental biology ,Mitochondrial permeability transition pore ,chemistry ,nervous system ,biology.protein ,cardiovascular system ,Mitochondrial fission ,Female ,Calcium-Calmodulin-Dependent Protein Kinase Type 2 - Abstract
Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by which chronic β-AR stimulation leads to mPTP openings is elusive. Here, we show that chronic administration of isoproterenol (ISO) persistently increases the frequency of mPTP openings followed by mitochondrial damage and cardiac dysfunction. Mechanistically, this effect is mediated by phosphorylation of mitochondrial fission protein, dynamin-related protein 1 (Drp1), by Ca2+/calmodulin-dependent kinase II (CaMKII) at a serine 616 (S616) site. Mutating this phosphorylation site or inhibiting Drp1 activity blocks CaMKII- or ISO-induced mPTP opening and myocyte death in vitro and rescues heart hypertrophy in vivo. In human failing hearts, Drp1 phosphorylation at S616 is increased. These results uncover a pathway downstream of chronic β-AR stimulation that links CaMKII, Drp1 and mPTP to bridge cytosolic stress signal with mitochondrial dysfunction in the heart., β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xu et al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.
- Published
- 2016
25. Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
- Author
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Yuping Lai, Hongquan Li, Yuanqi Liu, Tian Zhang, Zhenhua Wang, Zhaofan Xia, Shizhao Ji, Dongqing Li, Yanchun Quan, Hu Lei, Jilong Lu, Ziwei Jiang, Wang Wang, Keiwei Liu, Katherine A. Radek, and Yelin Wu
- Subjects
0301 basic medicine ,Adult ,Keratinocytes ,Male ,Science ,General Physics and Astronomy ,Gene Expression ,Inflammation ,Dermatitis ,Pancreatitis-Associated Proteins ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Diabetes mellitus genetics ,0302 clinical medicine ,RNA interference ,Glycation ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Animals ,Humans ,Cells, Cultured ,Aged ,Skin ,Mice, Knockout ,Mice, Inbred BALB C ,Multidisciplinary ,integumentary system ,business.industry ,General Chemistry ,Middle Aged ,medicine.disease ,Toll-Like Receptor 3 ,Mice, Inbred C57BL ,030104 developmental biology ,030220 oncology & carcinogenesis ,Hyperglycemia ,TLR3 ,Immunology ,Phosphorylation ,Female ,RNA Interference ,medicine.symptom ,business ,Wound healing - Abstract
Dysregulated inflammatory responses are known to impair wound healing in diabetes, but the underlying mechanisms are poorly understood. Here we show that the antimicrobial protein REG3A controls TLR3-mediated inflammation after skin injury. This control is mediated by REG3A-induced SHP-1 protein, and acts selectively on TLR3-activated JNK2. In diabetic mouse skin, hyperglycaemia inhibits the expression of IL-17-induced IL-33 via glucose glycation. The decrease in cutaneous IL-33 reduces REG3A expression in epidermal keratinocytes. The reduction in REG3A is associated with lower levels of SHP-1, which normally inhibits TLR3-induced JNK2 phosphorylation, thereby increasing inflammation in skin wounds. To our knowledge, these findings show for the first time that REG3A can modulate specific cutaneous inflammatory responses and that the decrease in cutaneous REG3A exacerbates inflammation in diabetic skin wounds., Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.
- Published
- 2016
26. Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
- Author
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Wu, Yelin, primary, Quan, Yanchun, additional, Liu, Yuanqi, additional, Liu, Keiwei, additional, Li, Hongquan, additional, Jiang, Ziwei, additional, Zhang, Tian, additional, Lei, Hu, additional, Radek, Katherine A., additional, Li, Dongqing, additional, Wang, Zhenhua, additional, Lu, Jilong, additional, Wang, Wang, additional, Ji, Shizhao, additional, Xia, Zhaofan, additional, and Lai, Yuping, additional
- Published
- 2016
- Full Text
- View/download PDF
27. CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
- Author
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Xu, Shangcheng, primary, Wang, Pei, additional, Zhang, Huiliang, additional, Gong, Guohua, additional, Gutierrez Cortes, Nicolas, additional, Zhu, Weizhong, additional, Yoon, Yisang, additional, Tian, Rong, additional, and Wang, Wang, additional
- Published
- 2016
- Full Text
- View/download PDF
28. Interplay between plasmon and single-particle excitations in a metal nanocluster
- Author
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Jie Ma, Lin-Wang Wang, and Zhi Wang
- Subjects
Physics ,Multidisciplinary ,Rabi cycle ,Condensed matter physics ,Phonon ,Surface plasmon ,General Physics and Astronomy ,Physics::Optics ,Nanotechnology ,General Chemistry ,Resonance (particle physics) ,Surface plasmon polariton ,General Biochemistry, Genetics and Molecular Biology ,Article ,Physics::Atomic and Molecular Clusters ,Surface plasmon resonance ,Plasmon ,Localized surface plasmon - Abstract
Plasmon-generated hot carriers are used in photovoltaic or photochemical applications. However, the interplays between the plasmon and single-particle excitations in nanosystems have not been theoretically addressed using ab initio methods. Here we show such interplays in a Ag55 nanocluster using real-time time-dependent density functional theory simulations. We find that the disappearance of the zero-frequency peak in the Fourier transform of the band-to-band transition coefficient is a hallmark of the plasmon. We show the importance of the d-states for hot-carrier generations. If the single-particle d-to-s excitations are resonant to the plasmon frequency, the majority of the plasmon energy will be converted into hot carriers, and the overall hot-carrier generation is enhanced by the plasmon; if such resonance does not exist, we observe an intriguing Rabi oscillation between the plasmon and hot carriers. Phonons play a minor role in plasmonic dynamics in such small systems. This study provides guidance on improving plasmonic applications., Plasmons can enhance hot-carrier generation for efficient photochemical reactions, but the interplay between plasmons and single-particle excitations are difficult to capture in models. Here, the authors use real-time time-dependent density functional theory to study these interactions in silver nanocrystals.
- Published
- 2015
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