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Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.

CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.

Chemically functionalized graphene oxide-based pn junction diodes have potential for future electronic device applications. Here, the authors report an all carbon pn diode with graphene oxide and carbon nanotubes electrodes showing excellent current rectification and efficient logic gates.